... by reducing the PKC-dependent AKT activity and elevating JNK phosphorylation. Since it was thought that GqPCR induces mainly activation of AKT, we undertook to examine how general is this phenomenon and understand its signaling. Methods: We used various cells to follow the phosphorylation of signaling...

.... Hepatic fibrosis Diabetes PAR2 PAK PKC Astragaloside Cellular Physiology Cell Physiol Biochem 2017;41:1156-1166 and Biochemistry DOOII::1100.1.1115599/0/000464461421222 © 2017 The Autho©r(s2).0P1u7bTlihseheAdubthyoSr(.sK)arger AG, Basel Pubblliisshheeddoonnlilninee: F: eFberburaurayr2y82...

.... Thus, we aimed to investigate the mechanisms by which α1-AR stimulation regulates I Kr . Methods: α1-adrenoceptors, hERG channels, auxiliary subunits minK and MIRP1, the non PIP 2 -interacting mutant D-hERG (with a deletion of the 883-894 amino acids) in the C-terminal and the non PKC-phosphorylable...

... cells. Interestingly, blocking AT1 and AT1 siRNA evidently inhibited Ang II-induced cell proliferation and inflammatory responses in HCC cells. More importantly, these effects may be mediated by AT1/PKC/NF-κB signaling pathway in HCC cell lines. Conclusions : The results propose that Ang II/AT1/PKC/NF...

... effect could be blocked by PKC or CaMKII inhibitors as well as EP1 receptor antagonist, and mimicked by PMA or EP1 receptor agonist. Furthermore, Western blot data showed that PGE 2 did not increase the total expression level of GABA A receptors, but significantly increased surface levels of GABA A β1/2...

... binding sites exerted negative effects on the cox-2 promoter activity. Among the signaling components of FcHRI, Fyn, PI 3-kinase, Akt, and p38 MAPK positively mediated the COX-2 expression. Conventional PKCs and atypical PKCs exerted opposite regulatory effects on the cox-2 promoter activity. Blockade...

... Sepsis Phagocytosis Cytokines NF-ĸB MAPK Akt PKC Insulin Diabetes Mellitus Alveolar macrophages Cellular Physiology and Biochemistry Review Cell Physiol Biochem 2012;29:01-08 Accepted: November 21, 2011 Briefs on Insulin and Innate Immune Response Karen K. S. Sunahara1, Paulina Sannomiya2...

...-induced pericellular hypoxia and CoCl 2 -induced hypoxia, specific inhibitors of p38 MAPK could concentration-dependently block those effects of hypoxia on AQP1 expression. Intracellular calcium ion (Ca 2+ ) and protein kinase C (PKC) were shown to be responsible for the activation of p38 MAPK pathway...

...Zheng Wang; Victor N. Bildin; Hua Yang; José E. Capó-Aponte; Yuanquan Yang; Peter S. Reinach Epidermal growth factor (EGF) receptor stimulation or protein kinase C (PKC) activation enhances corneal epithelial cell proliferation. This response is needed to maintain corneal transparency and vision...

... of signaling pathways. Results: Relative to non-diabetic rats, the diabetic rats exhibited a significant reduction in OA-induced phosphorylation of the extracellular signal-regulated kinase (ERK, 59%), p38 (53%), protein kinase B (Akt, 46%), protein kinase C (PKC)- α (63%) and PKC-δ (38%) in lung homogenates...

... ethanol stimulation in either treatment. Conclusion: Signaling of ethanol-induced insulin secretion from INS-1 and INS-1E cell lines bypasses calcium and PKC involving steps, is sensitive to tetanus toxin but resistant to N-ethymaleimide and ZnCl 2 . An extra pool of secretory vesicles not available...

... intracellular Ca 2+ levels via regulation of phospholipase C (PLC) and activated protein kinase C (PKC). LA activated phosphatidylinositol 3-kinase (PI3K)/Akt and p44/42 mitogen-activated protein kinases (MAPKs). U73122 (PLC inhibitor), staurosporine (PKC inhibitor), LY294002 (PI3K inhibitor), and Akt inhibitor...

... MAPKs PKA PKC Sugar Cellular Physiology and Biochemistry Original Paper Cell Physiol Biochem 2008;22:715-724 Accepted: September 02, 2008 Lipopolysaccharide Induces Inhibition of Galactose Intestinal Transport in Rabbits in vitro Pilar Amador1, M. Carmen Marca2,5, Josefina García-Herrera1, M...

... of IL-6Rα and glycoprotein (gp) 130 (IL-6Rβ) protein expression, Janus Kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3, PKC, p44/42 MAPKs phosphorylation, and PPARδ protein expression. Inhibition of each pathways blocked IL-6-induced [ 3 H]thymidine incorporation increase. IL-6...

...L.C. Schlichter; I. Chung; M.C. Chang Voltage-activated Kv1.3 channels, which are involved in normal functions of human T lymphocytes, contain consensus sites for phosphorylation by PKA, PKC, and CaMKII. Because T-cell functions often depend on second-messenger pathways involving serine/threonine...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Rat Liver Cell volume Volume regulation Cation channel PKC Isoform Cellular Physiology and Biochemistry Original Paper Cell Physiol Biochem...

... MAPK, PI3K and PKCs and inhibits a downstream effect of LPS, TNF production, in rat AMs stimulated with LPS and suggest that the protective effect of insulin in sepsis could be through modulation of signal transduction pathways elicited by LPS in lung macrophages. Cellular Physiology and Biochemistry...

... R -hydroxy-5, 8, 14- cis -10- trans -eicosatetraenoic acid, and LTD 4 did not activate mBLT1. U75302, specifically targeting BLT1, significantly reduced LTB 4 -evoked Cl - currents. Repetitive LTB 4 administration desensitized the LTB 4 -evoked currents. Activation of protein kinase C (PKC) by PMA...

... of ES cells and cell viability were not affected by the hypoxia (1 - 48h). Subsequently, [ 3 H] thymidine incorporation was significantly increased at 12 hours of hypoxic exposure. Hypoxia increased the Ca 2+ uptake and PKC β I , ε, and ζ translocation from the cytosol to the membrane fraction. Moreover...