...Zheng Xiao; Jia Wan; Ayub Abdulle Nur; Pencheng Dou; Henry Mankin; Tang Liu; Zhengxiao Ouyang Background/Aims: Drug resistance is the main difficulty for the current treatment for osteosarcoma. Cluster of differentiation 44 (CD44) is a receptor for hyaluronic acid (HA) and HA-binding has been...

... from any ideas, methods, instructions or products referred to in the content or advertisements. 2018 Osteosarcoma Long non-coding RNA urothelial carcinoma associated 1 microRNA-182 Tissue inhibitor of metallapeptidase 2 PI3K/AKT/GSK3β pathway NF-κB pathway Cellular Physiology Cell...

...Yazeng Huang; Jun Zhang; Haiyu Shao; Jianwen Liu; Mengran Jin; Jinping Chen; Hongying Zhao Background/Aims: Preventing cell metastasis is an effective therapeutic strategy to treat osteosarcoma and improve prognosis. Statins have been found to have anticancer effects in addition...

...Chenlei Zhu; Dong Cheng; Xubin Qiu; Ming Zhuang; Zhiwei Liu Background/Aims: Long noncoding RNAs (lncRNAs) have been a research hotspot, as they play important roles in tumor development. However, their expression pattern and biological function in osteosarcoma have not yet been clarified. Methods...

...Xuesong Wang; Lei Peng; Xiaojin Gong; Xiugong Zhang; Ruifu Sun; Jinlong Du Background/Aims: Increasing evidences suggest that dysregulated expression of miRNAs contributes to the progression of various tumors. However, the underlying function of miR-423-5p in osteosarcoma remains unexplored...

... in osteosarcoma. To investigate the mechanism of mutant p53-induced osteosarcoma metastasis, expression array analysis was performed, comparing non-metastatic osteosarcomas from p53+/- mice with metastatic osteosarcomas from p53R172H/+ mice. Onzin (Plac8) was identified as one of the genes upregulated in p53R172H...

...Chunming Jiang; Shenglin Ma; Runlei Hu; Xuepeng Wang; Maoqiang Li; Fei Tian; Wu Jiang; Liulong Zhu; Zhenyu Bian Background/Aims: Osteosarcoma, the most common primary bone malignancy, arises from primitive transformed cells of mesenchymal origin with the worldwide increasing morbidity and mortality...

...Tang Liu; Zuyun Yan; Yong Liu; Edwin Choy; Francis J. Hornicek; Henry Mankin; Zhenfeng Duan Background/Aims: Metastasis is the major cause of death in patients with osteosarcoma. There is an urgent need to identify molecular markers that promote metastasis. Cluster of differentiation 44...

...Guo Dai; Di Zheng; Weichun Guo; Jian Yang; An-yuan Cheng Background/Aims: Osteosarcoma is a common primary malignant bone tumor that mainly occurs in childhood and adolescence. Despite developments in the diagnosis and treatment of osteosarcoma, the prognosis is still very poor. Cinobufagin...

... and function in osteosarcoma. Methods: Expression of miR-330-3p in osteosarcoma tissues and cell lines was examined by quantitative PCR. Effects of miR-330-3p on osteosarcoma cell proliferation were investigated in vitro with the Cell Counting Kit-8 colorimetric assay. Targets of miR-330-3p were identified...

...Hui Ye; Jinkuang Lin; Xuedong Yao; Yizhong Li; Xiaobin Lin; Hai Lu Background/Aims: Increasing evidence demonstrates that long non-coding RNAs (lncRNAs) play critical regulatory roles in cancers, including osteosarcoma. A previous study showed that Nicotinamide Nucleotide Transhydrogenase-antisense...

... to uncover the mechanism of tumour suppression by miR-194. The expression of miR-194 in osteosarcoma cell lines and tissues were monitored by real-time PCR. Methods: The proliferation ability was examined by MTT assay. Migration and apoptosis of cells were monitored by migration assay and flow cytometry...

...Zhong Wu; Jie Liu; Siyuan Hu; Yuchang Zhu; Shaohua Li Background/Aims: Serine/threonine kinase 35 (STK35) may be associated with Parkinson disease and human colorectal cancer, but there have been no reports on the expression levels or roles of STK35 in osteosarcoma. Methods: STK35 mRNA expression...

...Ying Liu; Yan Zhang; Jilong Zou; Lixin Yan; Xiufeng Yu; Peng Lu; Xiaomeng Wu; Qiaozhi Li; Rui Gu; Daling Zhu Background/Aims: Osteosarcoma (OS) is the most common primary malignant tumor of bone tissue. Although treatment effectiveness has improved, the OS survival rate has fluctuated in recent...

...Tieying Tao; Qinrong Shen; Jianmin Luo; Yang Xu; Wenqing Liang Background/Aims: Increasing evidence has shown that miR-125a plays important role in human cancer progression. However, little is known about the function of miR-125a in osteosarcoma. Methods: The expression of miR-125a in osteosarcoma...

...Haifeng Lan; Wei Hong; Pan Fan; Dongyang Qian; Jianwei Zhu; Bo Bai Background/Aims: Osteosarcoma is a malignant tumor associated with high mortality; however, no effective therapies for the disease have been developed. Several studies have focused on elucidating the pathogenesis of osteosarcoma...

...Jilong Zou; Yan Zhang; Jiabing Sun; Xiaoyan Wang; Hualei Tu; Shuo Geng; Renhao Liu; Yuxi Chen; Zhenggang Bi Background/Aims: Osteosarcoma is the predominant form of primary bone malignancy. Although the combinational application of neoadjuvant chemotherapy and surgical resection significantly...

...Zhihong Li; Pengcheng Dou; Tang Liu; Shasha He Osteosarcoma is the most common primary bone malignancy in children and adolescents. Although improvements in therapeutic strategies were achieved, the outcome remains poor for most patients with metastatic or recurrent osteosarcoma. Therefore...

...Lin Fan; Chunyan Zhu; Rongmin Qiu; Pengfei Zan; Zhi Zheng; Tianyang Xu; Guodong Li Aim: Osteosarcoma (OS) is an aggressive bone malignancy that affects rapidly growing bones and is associated with a poor prognosis. Our previous study showed that cytochrome c1 (CYC1), a subunit of the cytochrome bc1...

...Lifeng Liu; Ying Xu; Russel J. Reiter; Yutao Pan; Di Chen; Yangzhou Liu; Xingyu Pu; Liguo Jiang; Zengchun Li Background: In a previous study, we found that melatonin inhibits MG-63 osteosarcoma cell proliferation; however, the underlying mechanisms remain elusive. Mitogen-activated protein kinase...