.... Clinical analyses of the role of CCL20 in tumor progression were performed based on the patient cohort of our institution. The role of CCL20 in tumor proliferation was evaluated by MTS assay, migration ability was measured by a Transwell assay, and osteoclastogenesis was induced by CCL20 or GCTSC...

... is a chronic and progressive disease caused by Mycobacterium tuberculosis and is characterized by bone loss due to an imbalance in bone remodeling and bone resorption [ 1-3 ]. Tuberculosis Th1 cells Osteoclastogenesis Interferon-γ © 2018 The Author(s). Published by S. Karger AG, Basel 2018...

... differentiation have not been fully elucidated. Our study aimed to identify the role of β-catenin in osteoclastogenesis and bone homeostasis. Methods: In the present study, exon 3 in the β-catenin gene ( Ctnnb1 ) allele encoding phosphorylation target serine/threonine residues was flanked by floxP sequences. We...

... by p38 inhibitor. Compared with control group, knockdown of p38 of breast cancer cells decreased cancer-induced osteoclastogenesis. Conclusion: Knockdown of BMPR1a of breast cancer cells suppresses their production of RANKL via p38 pathway and inhibits cancer-induced osteoclastogenesis, which indicates...

... of osteoclastogenic transcription factors, c-Fos and NFATc1. Moreover, PI markedly blocked the RANKL-induced osteoclastogenesis by attenuating MAPKs and NF-κB signaling pathways. In addition, PI decreased the ROS generation in osteoclast and osteoblast. Conclusion: Taken together our data demonstrate that PI has...

...Qing Wu; Xiaokang Zhou; Danqing Huang; Yingchen JI; Feiwu Kang Background/Aims: Evidence suggests that IL-6 affects bone mass by modulating osteocyte communication towards osteoclasts. However, the mechanism by which IL-6 enhances osteocyte-mediated osteoclastogenesis is unclear. We aimed...

... detected using tartrate-resistant acid phosphatase staining and calcium phosphate-coated plates. The expression of osteoclastogenesis-inducing molecules was detected by RT-PCR and western blotting in RANKL-treated bone marrow macrophages (BMMs). Cell viability and DNA synthesis were measured with MTT...

...Fangjing Chen; Bin Ni; Yueping Ou Yang; Tianwen Ye; Aimin Chen Background: Calcium ion (Ca 2+ ) signals are required for osteoclast differentiation. Previous study showed that transient receptor potential vanilloid 5 (TRPV5) is an essential Ca 2+ transporter in osteoclastogenesis and bone...

... differentiation have not been fully illustrated. We report that glycolysis and oxidative phosphorylation characterized by glucose and oxygen consumption as well as lactate production were increased during receptor activator of nuclear factor-ĸB ligand (RANKL)-induced osteoclastogenesis from RAW264.7 and bone...