... at least in part by S100A6's ability to facilitate cell cycle progression and to promote a pro-survival, anti-apoptotic phenotype in OS cells. Conversely, knockdown of endogenous S100A6 enhances the expression of apoptotic markers and induces cells to progress along the osteoblastic differentiation cascade...

... morphogenetic protein 9 (BMP9) is one of the most potent BMPs in regulating osteoblast differentiation of mesenchymal stem cells (MSCs) although the molecular mechanism underlying BMP9-induced osteogenesis remains to be fully elucidated. It is known that epigenetic regulations play an important role...