...Gang Zhong; Ruiming Liang; Jun Yao; Jia Li; Tongmeng Jiang; Jianwei Liu; Yiguan Le; Chong Shen; Huiping Long; Huiping Lu; Shiting Ma; Jun Luo; Zhikang Miao; Wei Su; Li Zheng; Jinmin Zhao Background/Aims: Current drug therapies for osteoarthritis (OA) are not practical because of the cytotoxicity...

...Yingliang Wei; Zhaofeng Jin; He Zhang; Shang Piao; Jinghan Lu; Lunhao Bai Background/Aims: Chondrocyte apoptosis is a central pathological feature of cartilage in osteoarthritis (OA). Accumulating evidence suggests that calcium ions (Ca 2+ ) are an important regulator of apoptosis. Previously, we...

... of JEZTC on osteoarthritis (OA) are still unclear. The goal of this study was to investigate the anti-osteoarthritic properties of JEZTC on interleukin-1-beta (IL-1β) stimulated chondrocytes in vitro and a rabbit anterior cruciate ligament transaction (ACLT) OA model in vivo . Methods: Changes in matrix...

... discovery for its relevant pharmacological properties in different pathogenic processes, including inflammation. Here, we investigated the involvement of OC in LPS-activated osteoarthritis (OA) human primary chondrocytes. Methods: Human primary chondrocytes were harvested from articular cartilage samples...

...Bing Zhang; Zhiyong Li; Wei Wang; Jichao Guo; Shufeng Kang; Shizhao Liu; Hongzhu Li; Dapeng Wang; Xiangbei Qi Background/Aims: Osteoarthritis (OA) is the most common joint disease. Recently, a novel variant near the nuclear receptor coactivator 3 ( NCOA3 ) has been identified in association...

... investigated the mechanism of Butein-mediated suppression of IL-6 expression in normal and human osteoarthritis (OA) chondrocytes under pathological conditions. Methods: Expression level of interleukin-6 (IL-6) protein in OA cartilage was analyzed by immunohistochemistry using a validated antibody...

...Xiaobin Li; Dengying Wu; Zhichao Hu; Jiangwei Xuan; Xiaoxia Ding; Gang Zheng; Zhenhua Feng; Wenfei Ni; Aimin Wu Background/Aims: Osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and a chondrocyte inflammatory response that induces an inflammatory environment...

...Xirui Yang; Qi Zhang; Zhaomeng Gao; Chunyan Yu; Lei Zhang Background/Aims: Interleukin-1 (IL-1) is known to be involved in cartilage degeneration following joint injury or due to osteoarthritis. In the present study, we explored the effects of miR-150 on IL-1-stimulated human chondrogenic cells...

..., including blood and synovial fluids. Increasing knowledge is emerging about exosomes in joint diseases, including osteoarthritis, rheumatoid arthritis, osteonecrosis of the femoral head, and others. Exosomes in synovial fluid can lead to inflammation, degeneration of cartilage, and destruction of joints...

...Pang-hu Zhou; Bo Qiu; Rong-hui Deng; Hua-jie Li; Xiong-feng Xu; Xi-fu Shang Background/Aims: Interleukin (IL)-1β plays an essential role in the pathophysiology of osteoarthritis (OA). Cytokine response modifier A (CrmA) can prevent the generation of active IL-1β. This study aimed to explore...

...Miguel Tofiño-Vian; Maria Isabel Guillén; María Dolores Pérez del Caz; Antonio Silvestre; María José Alcaraz Background/Aims: Chronic inflammation contributes to cartilage degeneration during the progression of osteoarthritis (OA). Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great...

...Yingliang Wei; Dianbin Zheng; Xiaocheng Guo; Min Zhao; Linlin Gao; Lunhao Bai Background/Aims: Chondrocyte apoptosis is the most common pathological feature in cartilage in osteoarthritis (OA). Transient receptor potential channel vanilloid 5 (TRPV5) is important in regulating calcium ion (Ca 2...

... in the progression of osteoarthritis (OA). Here, we aimed to determine whether the expression of ADAMTS-4/5 in chondrogenesis and inflammation is regulated by microRNA-92a-3p (miR-92a-3p). Methods: MiR-92a-3p and ADAMTS-4/5 expressions were determined by quantitative polymerase chain reaction (qPCR). To investigate...

...Wei-Ping Chen; Zhong-Nan Hu; Li-Bin Jin; Li-Dong Wu Background: Osteoarthritis (OA) is a joint disease in which cartilage degradation is the central pathological change. In this study, we investigated the anti-osteoarthritic effects of licochalcone A (Lico A) in rat chondrocytes. Methods...

...Xiaorui Jiang; Botao Huang; Huiying Yang; Guishi Li; Chunlei Zhang; Guangshi Yang; Feng Lin; Guodong Lin Background/Aims: Osteoarthritis (OA) is characterized by degradation of cartilage, sole cell type of which is chondrocytes. Bone marrow-derived mesenchymal stem cells (BMSCs) possess...

...Yuan Yuan; Honglue Tan; Pengyi Dai Background/Aims: Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process. However, the roles of KLF2 in chondrocytes and the pathological progression of osteoarthritis (OA...

...Yingliang Wei; Yanfang Wang; Yutong Wang; Lunhao Bai Background: Autophagy, a self-protective mechanism of chondrocytes, has become a promising target to impede the progress of osteoarthritis (OA). Autophagy is regulated by cytosolic Ca 2+ activity and may thus be modified by the Ca 2+ permeable...

...Li Qi; Yonggang Tang; Yong You; Fengling Qin; Lijuan Zhai; Hongxia Peng; Rongrong Nie Background: The electroacupuncture (EA) with different number of points significantly affected its efficacy on knee osteoarthritis (KOA), and the severity of KOA also influenced its response to treatments. Hence...

... to in the content or advertisements. Obesity Glycosaminoglycans Chondrogenesis Osteoarthritis Joint health Adipogenesis Obesity and degenerative joint disease (osteoarthritis) are multifactorial pathologies that are becoming major public health issues with the aging of the world population...

...Huaming Xue; Yihui Tu; Tong Ma; Xiaodong Liu; Tao Wen; Minwei Cai; Zhidao Xia; Jiong Mei Background/Aims: Chondrocyte apoptosis is largely responsible for cartilage degeneration in osteoarthritis (OA). Interleukin-1 beta (IL-1β) is widely used as a chondrocyte apoptosis-inducing agent, while...