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Keywords: Osteoarthritis
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Cellular Physiology and Biochemistry (2019) 51 (6): 2575–2590.
Published Online: 11 December 2018
...Gang Zhong; Ruiming Liang; Jun Yao; Jia Li; Tongmeng Jiang; Jianwei Liu; Yiguan Le; Chong Shen; Huiping Long; Huiping Lu; Shiting Ma; Jun Luo; Zhikang Miao; Wei Su; Li Zheng; Jinmin Zhao Background/Aims: Current drug therapies for osteoarthritis (OA) are not practical because of the cytotoxicity...
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Cellular Physiology and Biochemistry (2018) 49 (6): 2396–2413.
Published Online: 27 September 2018
...Bing Zhang; Zhiyong Li; Wei Wang; Jichao Guo; Shufeng Kang; Shizhao Liu; Hongzhu Li; Dapeng Wang; Xiangbei Qi Background/Aims: Osteoarthritis (OA) is the most common joint disease. Recently, a novel variant near the nuclear receptor coactivator 3 ( NCOA3 ) has been identified in association...
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Cellular Physiology and Biochemistry (2018) 49 (3): 932–946.
Published Online: 05 September 2018
... investigated the mechanism of Butein-mediated suppression of IL-6 expression in normal and human osteoarthritis (OA) chondrocytes under pathological conditions. Methods: Expression level of interleukin-6 (IL-6) protein in OA cartilage was analyzed by immunohistochemistry using a validated antibody...
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Cellular Physiology and Biochemistry (2018) 48 (6): 2583–2595.
Published Online: 17 August 2018
...Xiaobin Li; Dengying Wu; Zhichao Hu; Jiangwei Xuan; Xiaoxia Ding; Gang Zheng; Zhenhua Feng; Wenfei Ni; Aimin Wu Background/Aims: Osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and a chondrocyte inflammatory response that induces an inflammatory environment...
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Cellular Physiology and Biochemistry (2018) 47 (6): 2579–2588.
Published Online: 11 July 2018
...Xirui Yang; Qi Zhang; Zhaomeng Gao; Chunyan Yu; Lei Zhang Background/Aims: Interleukin-1 (IL-1) is known to be involved in cartilage degeneration following joint injury or due to osteoarthritis. In the present study, we explored the effects of miR-150 on IL-1-stimulated human chondrogenic cells...
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Cellular Physiology and Biochemistry (2018) 47 (5): 2008–2017.
Published Online: 03 July 2018
..., including blood and synovial fluids. Increasing knowledge is emerging about exosomes in joint diseases, including osteoarthritis, rheumatoid arthritis, osteonecrosis of the femoral head, and others. Exosomes in synovial fluid can lead to inflammation, degeneration of cartilage, and destruction of joints...
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Cellular Physiology and Biochemistry (2018) 47 (1): 11–25.
Published Online: 09 May 2018
...Miguel Tofiño-Vian; Maria Isabel Guillén; María Dolores Pérez del Caz; Antonio Silvestre; María José Alcaraz Background/Aims: Chronic inflammation contributes to cartilage degeneration during the progression of osteoarthritis (OA). Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great...
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Cellular Physiology and Biochemistry (2018) 45 (3): 1241–1251.
Published Online: 09 February 2018
...Feng Li; Jianguang Sun; Shilei Huang; Gao Su; Guofu Pi Background/Aims: Osteoarthritis (OA) is the most frequently occurring joint disease and characterized by degeneration of cartilage. As the unique cell type in cartilage, chondrocytes play a crucial role during OA. Our study explored...
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Cellular Physiology and Biochemistry (2018) 44 (1): 38–52.
Published Online: 03 November 2017
... in the progression of osteoarthritis (OA). Here, we aimed to determine whether the expression of ADAMTS-4/5 in chondrogenesis and inflammation is regulated by microRNA-92a-3p (miR-92a-3p). Methods: MiR-92a-3p and ADAMTS-4/5 expressions were determined by quantitative polymerase chain reaction (qPCR). To investigate...
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Cellular Physiology and Biochemistry (2017) 43 (3): 937–944.
Published Online: 29 September 2017
...Wei-Ping Chen; Zhong-Nan Hu; Li-Bin Jin; Li-Dong Wu Background: Osteoarthritis (OA) is a joint disease in which cartilage degradation is the central pathological change. In this study, we investigated the anti-osteoarthritic effects of licochalcone A (Lico A) in rat chondrocytes. Methods...
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Cellular Physiology and Biochemistry (2017) 42 (6): 2159–2168.
Published Online: 15 August 2017
...Yuan Yuan; Honglue Tan; Pengyi Dai Background/Aims: Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process. However, the roles of KLF2 in chondrocytes and the pathological progression of osteoarthritis (OA...
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Cellular Physiology and Biochemistry (2016) 39 (6): 2331–2340.
Published Online: 11 November 2016
...Li Qi; Yonggang Tang; Yong You; Fengling Qin; Lijuan Zhai; Hongxia Peng; Rongrong Nie Background: The electroacupuncture (EA) with different number of points significantly affected its efficacy on knee osteoarthritis (KOA), and the severity of KOA also influenced its response to treatments. Hence...
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Cellular Physiology and Biochemistry (2015) 37 (5): 1792–1806.
Published Online: 13 November 2015
... previously [ 20 ]. Obesity Glycosaminoglycans Chondrogenesis Osteoarthritis Joint health Adipogenesis Obesity and degenerative joint disease (osteoarthritis) are multifactorial pathologies that are becoming major public health issues with the aging of the world population. The relationship...