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Keywords: Orai1
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Cellular Physiology and Biochemistry (2018) 51 (3): 1164–1178.
Published Online: 27 November 2018
...Letizia Albarran; Jose J. Lopez; Isaac Jardin; Jose Sanchez-Collado; Alejandro Berna-Erro; Tarik Smani; Pedro J. Camello; Gines M. Salido; Juan A. Rosado Background/Aims: STIM1 and Orai1 are the key components of store-operated Ca 2+ entry (SOCE). Among the proteins involved in the regulation...
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Cellular Physiology and Biochemistry (2018) 47 (3): 1310–1317.
Published Online: 15 June 2018
... is found in NAFLD patients, and associated with metabolic syndrome and type-2 diabetes. NFκB is known to upregulate Orai1, the Ca 2+ channel responsible for store-operated Ca 2+ entry. The present study explored the role of NEFA-sensitive NFκB-dependent Orai1 expression in the regulation of lipid synthesis...
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Cellular Physiology and Biochemistry (2018) 46 (3): 1042–1054.
Published Online: 13 April 2018
... subunit (Orai1) and initiates store-operated Ca 2+ entry (SOCE). Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is a regulator of SOCE, but how CaMKII regulates SOCE remains obscure. Methods: Using Fura2, confocal microscopy, co-immunoprecipitation, specific blocker and overexpression/knockdown...
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Cellular Physiology and Biochemistry (2018) 45 (4): 1707–1716.
Published Online: 23 February 2018
... be triggered by activation with collagen related peptide (CRP). CRP-induced platelet apoptosis is characterized by cell membrane scrambling with phosphatidylserine exposure to the platelet surface and cell shrinkage, preceded by externalization of Ca 2+ channel Orai1, increase of cytosolic Ca 2+ -activity ([Ca...
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Cellular Physiology and Biochemistry (2016) 40 (5): 1141–1152.
Published Online: 14 December 2016
.... Chorein is effective in part by interacting with and fostering stimulation of phosphoinositide-3-kinase (PI3K)-p85-subunit. PI3K dependent signaling includes the serum and glucocorticoid inducible kinase SGK1. The kinase activates NFκB with subsequent up-regulation of the Ca 2+ channel subunit Orai1...
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Cellular Physiology and Biochemistry (2016) 38 (6): 2183–2193.
Published Online: 17 May 2016
...Lane Zhang; Limin Wang; Shu Li; Jingyi Xue; Dali Luo Background/Aims: Stromal interacting molecule-1 (STIM1) aggregation and redistribution to plasma membrane to interact with Orai1 constitute the core mechanism of store-operated Ca 2+ entry (SOCE). Previous study has revealed that calsequestrin-1...
Journal Articles
Cellular Physiology and Biochemistry (2016) 38 (4): 1643–1651.
Published Online: 28 April 2016
... (SOCE). [Ca 2+ ] i could be decreased by Ca 2+ extrusion via Na + /Ca 2+ exchange. Mechanisms accomplishing SOCE include the pore-forming ion channel unit Orai1 and its regulator STIM1, Na + /Ca 2+ exchanger isoforms include NCX1. In MCF-7 breast carcinoma cells Orai1 and NCX1 have previously been shown...
Journal Articles
Cellular Physiology and Biochemistry (2016) 38 (2): 683–695.
Published Online: 08 February 2016
... (SOCE) accomplished by the pore-forming ion channel unit Orai1 and its regulator STIM1, as well as Ca 2+ extrusion by Na + /Ca 2+ exchanger NCX1. Kinases participating in the orchestration of cell proliferation include the Janus activated kinase JAK2. The present study explored the impact...
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Cellular Physiology and Biochemistry (2013) 32 (3): 687–698.
Published Online: 13 September 2013
... + and CD8 + T-cells were similar in ampk -/- and ampk +/+ T-lymphocyte blasts. Moreover, total STIM1 protein abundance was similar in ampk -/- and ampk +/+ T-lymphocyte blasts. However, Orai1 cell membrane protein abundance was significantly higher in ampk -/- than in ampk +/+ T-lymphocyte blasts. SOCE...