...Jèssica Latorre; José M. Moreno-Navarrete; Mónica Sabater; Maria Buxo; José I. Rodriguez-Hermosa; Jordi Girones; José M. Fort; Ramón Vilallonga; Wifredo Ricart; Rafael Simo; Jose-Manuel Fernandez-Real; Francisco J. Ortega Background/Aims: Obesity is characterized by the immune activation...

... was conducted using SNPstats (online software: http://bioinfo.iconcologia.net/SNPstats ). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among 5 SNPs within XRCC gene and obesity. Results: Logistic regression analysis showed that the C allele...

...Minseo Kwon; Ji Eom; Donghwan Kim; Jinhwan Kim; Jose Heredia; Sang-Wook Kang; Youngsup Song Background/Aims: Obesity is a serious health risk factor strongly associated with insulin resistance and type 2 diabetes; however, the underlying mechanisms associating obesity with insulin resistance remain...

... including visceral obesity, inflammation, hyperlipidemia and hepatic fibrosis which are similar to that of the human NAFLD [ 15 ]. It has been reported that all the rats developed perisinosodial fibrosis after 24 weeks’ HFD feeding [ 14 ]. Similar results were observed in mice [ 16, 17 ]. These reports...

...Pengjiao Xi; Jianying Du; Huimin Liang; Jie Han; Zhaoxia Wu; Haomin Wang; Lu He; Qiming Wang; Haize Ge; Yongmei Li; Jie Xue; Derun Tian Background/Aims: Obesity is increasingly becoming a major public health problem worldwide. Peripheral LKB1 inhibits white fat generation, but the effect of central...

...Jaume Amengual; Francisco J. García-Carrizo; Andrea Arreguín; Hana Mušinović; Nuria Granados; Andreu Palou; M. Luisa Bonet; Joan Ribot Background/Aims: All-trans retinoic acid (ATRA) has protective effects against obesity and metabolic syndrome. We here aimed to gain further insight...

... mechanisms remain elusive. Recent literature provides mechanistic evidences of detrimental effects of psychosocial stress on physiology of different body organs including liver. The data of stress-induced pathophysiological changes in liver functions and obesity were systematically collected from PubMed...

... transaminase (AST) and insulin. Knockdown of ClC-2 in liver attenuated HFD-induced weight gain, obesity, hepatocellular ballooning, and liver lipid accumulation and fibrosis, accompanied by reduced plasma free fatty acid (FFA), triglyceride (TG), total cholesterol (TC), ALT, AST, glucose and insulin levels...

...Sardar Sindhu; Nadeem Akhter; Shihab Kochumon; Reeby Thomas; Ajit Wilson; Steve Shenouda; Jaakko Tuomilehto; Rasheed Ahmad Background/Aims: Metabolic diseases such as obesity and type-2 diabetes (T2D) are known to be associated with chronic low-grade inflammation called metabolic inflammation...

... together with uncoupling protein 1 found as a marker protein of brown adipose tissue (BAT) fat. In addition, TASK-1 was linked in a genome-wide association study to an increased body mass index. A recent study showed that TASK-1 inhibition is causing obesity in mice by a BAT whitening...

...Qiang Li; Rongbing Jin; Hao Yu; Hongmei Lang; Yuanting Cui; Shiqiang Xiong; Fang Sun; Chengkang He; Daoyan Liu; Hongbo Jia; Xiaowei Chen; Sijiao Chen; Zhiming Zhu Background/Aims: Obesity and high salt intake are major risk factors for hypertension and cardiometabolic diseases. Obese individuals...

...Qianqian Dong; Wenjuan Xing; Feifei Su; Xiangyan Liang; Fei Tian; Feng Gao; Siwang Wang; Haifeng Zhang Aims: Obesity is a major risk for hypertension. Endothelial dysfunction contributes to increased peripheral vascular resistance and subsequent hypertension. Autophagy regulates endothelial...

...Xiangrong Cui; Chunlan Long; Jing Zhu; Jie Tian Background: Statins can reduce reproductive damage induced by obesity or high-fat diet (HFD), but the specific regulatory mechanisms are largely unknown. Since mTOR/p70s6k sinaling promotes spermatogonia proliferation and spermatogenesis, we...

... of diabetes and diabetes-related diseases. 2-dodecyl-6-methoxycycyclohexa-2,5-1,4-dione (DMDD) has been isolated from A. carambola L. roots, and this study was carried out to investigate the potential beneficial effects of DMDD on obesity and insulin resistance induced by a high-fat diet (HFD) in mice...

... rate, clinical pregnancy rate, miscarriage rate and live births among PCOS and non-PCOS patients were compared between different BMIs. Results: IVF/ICSI pregnancies in obese PCOS women had a considerably higher risk of miscarriage and low rate of clinical pregnancy than in non-obese PCOS pregnancies...

... to in the content or advertisements. Type 2 diabetes mellitus Lipid profiles Obesity Children Obesity is a complex condition and highly associated with dietary and nutritional issues. More than one third of adults and 17% of children are obese in the United States [ 1,2 ]. Obesity leads to multiple...

... mechanisms linking leptin and FGF21 are still needed. These results are of great interest in the context of identifying potential new clinical approaches to treat metabolic diseases associated with insulin resistance, such as obesity and type 2 diabetes. Human derived hepatocarcinoma HepG2 cells (American...

...Xiao Zhai; Guangfang Qian; Yiran Wang; Xiao Chen; Jiancan Lu; Yaping Zhang; Qin Huang; Qijin Wang Background/Aims: Despite strong association between obesity and the pathogenesis of type 2 diabetes (T2D), only a subset of obese individuals eventually develops T2D. We sought to determine...

... and inhibition of GSK3α/β and β-catenin signaling as a potent molecular target for obesity. 13 10 2015 17 11 2015 Preadipocyte 3T3-L1 cells were fixed with 2% paraformaldehyde at room temperature for 1 h. After fixation, the cells were washed with 60% isopropanol for 5 min and then subject...

...Petar D. Petrov; Nuria Granados; Carles Chetrit; Daniel Martínez-Puig; Andreu Palou; M. Luisa Bonet Background/Aims: Multipotent mesenchymal stem cells affect homeostasis of adipose and joint tissues. Factors influencing their differentiation fate are of interest for both obesity and joint problems...