...Shousen Hu; Yongliang Yuan; Zhizhen Song; Dan Yan; Xiangzhen Kong Background/Aims: Drug resistance remains a main obstacle to the treatment of non- small cell lung cancer (NSCLC). The aim of this study was to identify the expression profiles of microRNAs (miRNAs) in drug-resistant NSCLC cell lines...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2018 Il-35 Non-small Cell Lung Cancer NSCLC Interleukin-35 Cellular Physiology Cell Physiol Biochem 2018;51:1839...

... as metabolic coupling between neighboring cells. Here, we investigated the role of connexin 43 (Cx43) and its derived GJIC in the interplay between non-small cell lung cancer (NSCLC) cells and cancer-associated fibroblasts (CAFs). Methods: CAFs and NSCLC cells were co-cultured with direct contact and separated...

...-AS1) has been associated with non-small cell lung cancer (NSCLC). However, it remains unclear how AFAP1-AS1 participates in the development and progression of NSCLC. Methods: The peripheral blood samples were collected from patients with NSCLC. White blood cell subsets were classified and levels...

... immunoregulatory activity in non-small cell lung cancer (NSCLC). Thus, we investigated the role of IL-35 in the pathogenesis of this disease. Methods: A total of 66 NSCLC patients and 21 healthy individuals were enrolled. IL-35 expression in peripheral blood and bronchoalveolar lavage fluid (BALF) was measured...

...Fengming Yang; Ke Wei; Zhiqiang Qin; Weitao Liu; Chuchu Shao; Chaoshan Wang; Ling Ma; Mengyan Xie; Yongqian Shu; Hua Shen Background/Aims: MicroRNAs regulate a wide range of biological processes of non-small cell lung cancer (NSCLC). Although miR-598 has been reported to act as a suppressor...

...Cheng-Liang Yang; Xiao-Li Zheng; Ke Ye; Hong Ge; Ya-Nan Sun; Yu-Fei Lu; Qing-Xia Fan Backgrounds/Aims: MicroRNAs (miRs) often contribute to the progression of non-small cell lung cancer (NSCLC) via regulation of mRNAs that are involved in lung homeostasis. We conducted a study aimed at exploring...

... non-small cell lung cancer (NSCLC) cells are partially resistant to TRAIL, thereby limiting its clinical application. Therefore, there is a need for the development of novel adjuvant therapeutic agents to be used in combination with TRAIL. Methods: In this study, the effect of N-acetyl-glucosamine...

...Xitao Chen; Xiaodi Sun; Jingqian Guan; Junda Gai; Jilin Xing; Lin Fu; Shuli liu; Feifei Shen; Keyan Chen; Wenya Li; Libo Han; Qingchang Li Background/Aims: The therapeutic efficacy of paclitaxel is hampered by chemotherapeutic resistance in non-small cell lung cancer (NSCLC). Rsf-1 enhanced...

...Yufei Zhou; Shaoxia Li; Jiangtao Li; Dongfeng Wang; Quanxing Li Objective: This study explored the ability of microRNA-135a (miR-135a) to influence cell proliferation, migration, invasion, apoptosis and tumor angiogenesis through the IGF-1/PI3K/Akt signaling pathway in non-small cell lung cancer...

...Cheng-Shi He; Yi-Cheng Liu; Zhi-Peng Xu; Peng-Chen Dai; Xiao-Wei Chen; De-Hai Jin Background: Chemoresistance is a major obstacle to successful chemotherapy for human non-small cell lung cancer (NSCLC). Astragaloside IV, the component of Astragalus membranaceus , has been reported to exhibit anti...

...Shu-Ying Hou; Yan-Ping Li; Jin-Hua Wang; Song-Ling Yang; Ying Wang; Yang Wang; Ye Kuang Background/Aims: Non-small cell lung cancer (NSCLC) is the leading cause of death worldwide. Although aquaporin-3 (AQP3) is widely distributed in mammalian tissues and over-expressed in NSCLC cells...

... inhibitor of survivin expression, on the radiosensitivity of human non-small cell lung cancer (NSCLC) cell lines and elucidated a relationship between the cellular localization of survivin and DNA double-strand break repair. Methods: The cellular distribution of survivin was determined by Western blotting...

...Zhicheng He; Yang Xia; Chunfeng Pan; Teng Ma; Bin Liu; Juejin Wang; Liang Chen; Yijiang Chen Background/Aims: MicroRNAs (miRNAs) have been regarded as a new class of regulators in cellular processes in non-small cell lung cancer (NSCLC). However, the relationship between miR-452 and the development...

...Chongbiao Huang; Ruijue Ma; Jie Yue; Na Li; Zengxun Li; Daliang Qi Background/Aims: To investigate the expression, clinical significance and the cellular effects of miR-497 in non-small cell lung cancer (NSCLC). Methods: NSCLC cells were transiently transfected with miR-497 mimics or siRNA to up...

...Zhennan Tian; Guodong Yao; Hongtao Song; Yang Zhou; Jingshu Geng Background: Insulin-like growth factor (IGF) pathway has been suggested as a new molecular target for the treatment of cancer including Non-small cell lung cancer (NSCLC). We postulated that IGF-2 receptor (IGF2R) may be associated...

...Chunlei Shi; Jialin Qian; Meili Ma; Yanwei Zhang; Baohui Han Aim: To study the relation of NOTCH3 and its gene polymorphisms with the chemotherapy response and the prognosis of patients with Non-small cell lung cancer (NSCLC). Methods: A total of 594 patients with advanced stage of NSCLC (IIIA...

...Fenglei Wu; Jian Zhang; Yi Liu; Yigong Zheng; Nan Hu Aim: To investigate whether the hypoxia-inducible factor-1α (HIF-1α) genetic variants and protein expression affect the chemotherapy response and the clinical outcome of patients with advanced non-small cell lung cancer (NSCLC). Methods: A total...