... to PACAP-27 or PACAP-38 before induction of experimental acute ischemic stroke via oxygen-glucose deprivation-reperfusion (OGD/R) injury. To reveal PACAP’s role in neuroprotection, we employed fluorescent live/dead cell viability and caspase 3 assays, optical densitometry of mitochondrial dehydrogenase...

... neurodegeneration-related oxidative stress. Circular RNAs (circRNAs) are involved with various diseases in the central nervous system (CNS). This study aimed to identify the key circRNAs involved in Nrf2-neuroprotection against oxidative stress. Methods: The differentially expressed circRNAs (DEcircRNAs...

...Fazhao Li; Jieqiong Tan; Fangfang Zhou; Zhiping Hu; Binbin Yang Background/Aims: We have reported the neuroprotective properties of Heat shock protein B8(HSPB8) against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury by inhibiting the mitochondrial apoptotic pathway. However...

... of excitatory transmitter release, and attenuation of disrupted neuronal transmission. During prolonged hypoxia/ischemia, however, DOR neuroprotection involves a variety of signaling pathways. More recently, our data suggest that DOR may display its neuroprotective role via the BDNF-TrkB pathway. This review...

.... Neuroprotection Retinal ganglion cells Müller cells PEDF Deutsche Foschungsgemeinschaft (DFG) 10.13039/501100001659 Pigment epithelium-derived factor (PEDF) is a multifunctional secreted 50-kDa glycoprotein with neuroprotective, neurotrophic, angioinhibitory, antioxidant, anti-inflammatory...

... activity Smooth muscle relaxation Cardioprotection Neuroprotection Acting as ATP-independent molecular chaperones, all sHSPs play important roles in protein house-keeping. sHSPs have low subunit molecular masses of 12-43 kDa and are characterized by the presence of a highly conserved region...

.... Intracerebral hemorrhage Axonal regeneration Stem cells Neuroprotection Cellular Physiology Cell Physiol Biochem 2017;42:137-144 and Biochemistry DOOII::1100.1.1115599/0/000474771721222 Pubblliisshheeddoonnlilninee: M: Mayay151,52,0210717 © 2017 The Autho©r(s2).0P1u7bTlihseheAdubthyoSr(.sK)arger AG, Basel...

...Dapeng Zhang; Guozhang Ma; Mingming Hou; Tao Zhang; Limin Chen; Chengbin Zhao Background : Acute spinal cord injury (SCI) leads to permanent disabilities. This study evaluated the neuroprotective effect of puerarin, a natural extract, in a rat model of SCI. Methods : Acute SCI models were...

...Xuelian Yang; Tetsuya Asakawa; Sha Han; Ling Liu; Wei Li; Weiwen Wu; Yunhe Luo; Wenjie Cao; Xin Cheng; Baoguo Xiao; Hiroki Namba; Chuanzhen Lu; Qiang Dong; Liang Wang Background/Aims: Neuroserpin (NSP) is known for its neuroprotective role in cerebral ischemic animal models and patients. Our...

... be restored by the neuroprotective effect of docosahexaenoic acid (DHA). Method: In the present study, using Seahorse XF-24 Metabolic Flux Analysis we investigated the effect of DHA and CoQ10 alone and in combination against Aβ- and zinc-mediated changes in the mitochondrial function of M17 neuroblastoma cell...

... the administration of H-1152P significantly reduced the extent of these events. Conclusion: H-1152P exerted a neuroprotective effect against necrosis on the isolated bovine retina under hypoxia together with a reduction in glial cell reactivity. However, the inhibitor could not prevent the hypoxia induced retinal...

... neuroprotection has been linked to selenite’s attenuation or inhibition of p38 mitogen-activated protein kinase, pSAPK/JNK, and Bax activation in in vitro and in vivo SCI lesion sites. Selenite also attenuated cell death via the prevention of cytochrome c release, caspase activation, and ROS accumulation...