...Dong Chen; Siyuan Hu; Zhong Wu; Jie Liu; Shaohua Li Background/Aims: microRNAs are of vital importance in neural development. As a brain-specific miRNA, miR-132 has been well studied in mature neurons. However, its role in neural stem cells (NSCs) remains unclear. In this study, we investigated...

...Pan Lu; Shan Lei; Weisong Li; Yang Lu; Juan Zheng; Ning Wang; Yongjun Xia; Haixia Lu; Xinlin Chen; Yong Liu; Peng-bo Zhang Background/Aims: Ketamine inhibits the proliferation of neural stem cells (NSCs) and disturbs normal neurogenesis. Dexmedetomidine provides neuroprotection against volatile...

...Zhongju Shi; Zhijian Wei; Jiahe Li; Shiyang Yuan; Bin Pan; Fujiang Cao; Hengxing Zhou; Yan Zhang; Yao Wang; Shiwei Sun; Xiaohong Kong; Shiqing Feng Background/Aims: Neural stem cells (NSCs) reside in a hypoxic environment, and hypoxia plays an important role in their development and differentiation...

... in a wide range of brain injury models. In the present study, we investigated whether simvastatin could attenuate neurogenetic inhibition and cognitive deficits induced by isoflurane exposure in neonatal rats. Methods: Sprague-Dawley rats at postnatal day (PND) 7 and neural stem cells (NSCs) were treated...

... about its role in neural stem cells (NSCs). This study examined whether EphB4 is required for proliferation and differentiation of human embryonic neural stem cells (hNSCs) in vitro . Methods: We up- and down-regulated EphB4 expression in hNSCs using lentiviral over-expression and shRNA knockdown...

... about the role of Shh signaling in resveratrol-enhanced neurogenesis after stroke. Methods: Neural stem cells (NSCs) before oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro were pretreated with resveratrol with or without cyclopamine. Survival and proliferation of NSCs was assessed by the CCK8...

...Mingfeng Li; Xinlong Liu; Haiyan Yue; Weiming Xiong; Jianfeng Gu; Mao Xu Background/Aims: Neural stem cells (NSCs) hold considerable potential as a therapeutic tool for repair of the damaged nervous system. In the current study, we examined whether transplanted N-acetyl aspartyl-glutamate...

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