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Keywords: NSCLC
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Journal Articles
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Cellular Physiology and Biochemistry (2019) 51 (6): 2716–2731.
Published Online: 12 December 2018
... and biological roles of FOXD1 in non-small cell lung cancer (NSCLC) remain largely unknown. Methods: A total of 264 primary NSCLC tissue samples were collected. The expression levels of FOXD1 in these samples were examined by immunohistochemical staining. The expression of FOXD1 was knocked down by lentiviral...
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Cellular Physiology and Biochemistry (2018) 51 (5): 2160–2171.
Published Online: 06 December 2018
...Wei Sun; Wei Ping; Yitao Tian; Wenbin Zou; Jiawei Liu; Yukun Zu Background/Aims: KRas is usually mutated in non-small cell lung cancer (NSCLC). The mutated KRas gene is a negative prognostic indicator that promotes tumor proliferation, metastasis, and drug resistance in NSCLC, and thus has become...
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Cellular Physiology and Biochemistry (2018) 51 (4): 1839–1851.
Published Online: 30 November 2018
... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2018 Il-35 Non-small Cell Lung Cancer NSCLC Interleukin-35...
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Cellular Physiology and Biochemistry (2018) 50 (5): 2004–2016.
Published Online: 07 November 2018
...Yintao Li; Menglin Bai; Yali Xu; Weiwei Zhao; Naijia Liu; Jinming Yu Background/Aims: Non-small-cell lung carcinoma (NSCLC) is the leading cause of cancer death, with tumor metastasis being mainly responsible for lung cancer-associated mortality. Our previous studies have found that tubulin...
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Cellular Physiology and Biochemistry (2018) 50 (1): 304–316.
Published Online: 03 October 2018
... and development of many cancers. The purpose of this study was to investigate the role of the PAK1–cyclic AMP response element-binding (CREB) axis in non-small cell lung cancer (NSCLC) tumorigenesis and its related mechanisms. Methods: Western blot assay and immunohistochemical staining were employed...
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Cellular Physiology and Biochemistry (2018) 49 (3): 911–919.
Published Online: 05 September 2018
...Xin Yan; Hua Shen; Hongjian Jiang; Dan Hu; Jun Wang; Xinqi Wu Background/Aims: Lung cancer is one of the most prevalent malignancies in the world. The 5-year survival rate for non-small cell lung cancer (NSCLC) patients is only approximately 15%, with metastasis as the primary cause of death...
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Cellular Physiology and Biochemistry (2018) 48 (6): 2258–2272.
Published Online: 16 August 2018
...Xiao-Yuan Wu; Chen-Xi Zhang; Li-Chun Deng; Jie Xiao; Xin Yuan; Bin Zhang; Zhi-Bo Hou; Zhi-Hong Sheng; Lan Sun; Qi-Chen Jiang; Wei Zhao Background/Aims: Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. Dopamine receptor D2 (DRD2) has multiple roles in clinical...
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Cellular Physiology and Biochemistry (2018) 48 (5): 2046–2060.
Published Online: 10 August 2018
... of circRNAs in the chemoresistance of non-small cell lung cancer (NSCLC) to taxol. Methods: High-throughput circRNA microarrays were employed to investigate the circRNA profiles of parental A549 and taxol-resistant A549/Taxol cells. We predicted the miRNA targets of differentially expressed circRNAs via miRNA...
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Cellular Physiology and Biochemistry (2018) 48 (1): 138–148.
Published Online: 12 July 2018
... a key role in cell migration of non-small cell lung cancer (NSCLC). In this study, we report that Forkhead box class O1 (FOXO1) is downregulated in human NSCLC and that silencing of FOXO1 is associated with the invasive stage of tumor progression. Methods: The cell proliferation, migration, and invasion...
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Cellular Physiology and Biochemistry (2018) 46 (3): 999–1008.
Published Online: 13 April 2018
... carcinoma (NSCLC). Moreover, ASPP2 was directly targeted by miR-21 in NSCLC cells. Down-regulation of miR-21 suppressed cell migration and invasion, as well as the EMT signaling pathway in NSCLC cells. Furthermore, the miR-21 inhibitor induced cell apoptosis via the caspase dependent pathway in NSCLC cells...
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Cellular Physiology and Biochemistry (2018) 45 (6): 2213–2224.
Published Online: 10 March 2018
... been overlooked, and little is known regarding its specific function in non-small cell lung cancer (NSCLC). In this study, we explored IL-11’s role in NSCLC and the detailed mechanism behind it. Methods: Cell proliferation in response to IL-11 was determined by colony formation, BrdU incorporation...
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Cellular Physiology and Biochemistry (2018) 45 (5): 1827–1839.
Published Online: 28 February 2018
... transformation specific-1), a key transcription factor in the generation and maturation of ECs (endothelial cells), has been reported to be overexpressed in several cancers. Here, we reveal novel regulation of the endothelial-like differentiation of NSCLC (non-small cell lung cancer) cells by ETS-1. Methods: We...
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Cellular Physiology and Biochemistry (2018) 45 (5): 1807–1817.
Published Online: 28 February 2018
...), cell migration assay and invasion assay (transwell assay) were carried out to investigate the Harmine’s efficacy on non-small cell lung cancer (NSCLC) cells in vitro . A549-luciferase cell orthotropic transplantation xenograft mouse model was used to determine the effect of Harmine treatment on NSCLC...
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Cellular Physiology and Biochemistry (2018) 45 (3): 917–934.
Published Online: 02 February 2018
... process (BP), cell component (CC), and molecular function (MF) categories. Moreover, some candidate proteins involved in PARP1/AIF and nuclear Akt signaling pathways or metastasis processes were validated by western blotting. Conclusion: TP exerted anti-tumor activity on non-small cell lung cancer (NSCLC...
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Cellular Physiology and Biochemistry (2018) 44 (6): 2201–2211.
Published Online: 13 December 2017
... to investigate the role of PAI-1 in the tumor microenvironment. Methods: The expression and distribution patterns of PAI-1 and transforming growth factor beta (TGF-β) were measured in 60 non-small cell lung cancer (NSCLC) tumors. A statistical correlation analysis was performed between PAI-1 and TGF-β expression...