... cell population of colorectal cancer cells. Aspirin inhibited xenograft tumor growth and reduced tumor cells stemness in nude mice. Consistently, aspirin decreased the protein expression of stemness-related transcription factors, including c-Myc, OCT4 and NANOG. Suppression of NANOG blocked the effect...

... of mouse ESCs, Co-IP and miRNA analysis. Results: We found that SOX2 and NANOG bind the ALKBH1 promoter, and we identified protein-protein interactions between ALKBH1 and these core transcription factors of the pluripotency network. Furthermore, lack of ALKBH1 affected the expression of developmentally...

...Zhi-kun Guo; Kang Guo; Huanhuan Luo; Ling-min Mu; Qiong Li; Yu-qiao Chang Objectives: To investigate the expression dynamic of nanog gene in the development of rat myocardial tissues. Methods: SD rats were studied at 5 time points before and after birth. The techniques of immunohistochemistry...

...Li Yang; Xudong Zhang; Mingzhi Zhang; Junhui Zhang; Yuqiao Sheng; Xiangdong Sun; Qingjiang Chen; Le-Xin Wang Background/Aims: Nanog plays a key role in stem cell self-renewal and pluripotency differentiation in embryonic stem cells ( ESCs). Recently, some studies reported that abnormal expression...