... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Lipid droplets SIRT1 ATF6 Resveratrol NAFLD Non-alcoholic fatty liver disease (NAFLD) is a growing but serious threat to public health...

...Youlian Zhou; Tiying Zheng; Huiting Chen; Yongqiang Li; Hongli Huang; Wenji Chen; Yanlei Du; Jie He; Yuyuan Li; Jie Cao; Yuqiang Nie; Yongjian Zhou Background/Aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed...

...Tao-tao Ma; Cheng Huang; Ying Ni; You Yang; Jun Li Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease with unclear molecular mechanisms. Our study intended to identify potential long non-coding RNAs (lncRNAs) and genes, and to determine the potential...

...Hong Zhong; Mengting Liu; Yaya Ji; Minjuan Ma; Kun Chen; Tingming Liang; Chang Liu Background/Aims: Liver damage is a typical manifestation of nonalcoholic fatty liver disease (NAFLD). It originates from excessive fat accumulation, leading to hepatocyte death, inflammation, and fibrosis...

...Dandan Zhong; Zhengwei Xie; Boyue Huang; Shuai Zhu; Guoqian Wang; Hong Zhou; Shuqian Lin; Zhibin Lin; Baoxue Yang Background/Aims: Non-alcoholic fatty liver disease (NAFLD) encompasses a series of pathologic changes ranging from steatosis to steatohepatitis, which may progress to cirrhosis...

...Stanley Dumeus; Marthandam Asokan Shibu; Wan-Teng Lin; Ming-Fu Wang; Chao-Hung Lai; Chia-Yao Shen; Yueh-Min Lin; Vijaya Padma Viswanadha; Wei-Wen Kuo; Chih-Yang Huang Background/Aims: High-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) poses therapeutic challenges in elderly...

... disease High-fat-diet MCD diet NAFLD Caspase-3/7 activities were also measured using the Apo-ONE Homogeneous Caspase-3/7 assay kit (Promega, Madison, WI) according to the manufacturer’s instructions. Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver disease associated...

...Sungmin Lee; Beomseok Son; Jaewan Jeon; Gaeul Park; Hyunwoo Kim; Hyunkoo Kang; HyeSook Youn; Sunmi Jo; Jie-Young Song; BuHyun Youn Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is an emerging metabolic disease. Although it leads to severe hepatic diseases including steatohepatitis...

...Yi Lou; Yi-Dan Chen; Fu-Rong Sun; Jun-Ping Shi; Yu Song; Jin Yang Background and Aim: The incidence of nonalcoholic fatty liver disease (NAFLD), ranging from mild steatosis to hepatocellular injury and inflammation, increases with the rise of obesity. However, the implications of transcription...

...Lei Wang; Ning Zhang; Zun Wang; Dong-mei Ai; Zhen-yu Cao; Hua-ping Pan Background: Obesity is now a common risk factor for non-alcoholic fatty liver disease (NAFLD). Thus, it is important to explore its underlying mechanisms. Methods: Total RNA was extracted from peripheral whole blood samples from...

...Alexandra M. Hetherington; Cynthia G. Sawyez; Emma Zilberman; Alexandra M. Stoianov; Debra L. Robson; Nica M. Borradaile Background/Aims: Nonalcoholic fatty liver disease (NAFLD) progression to fibrosis, cirrhosis and hepatocellular carcinoma, alters the cellular composition of this organ. During...

... and eNOS dysfunction in endothelial cells from human umbilical vein [ 17 ]. Therefore, FGF21 has been proposed as a potential therapeutic target for the treatment of T2DM, obesity, and their associated complications, such as NAFLD. The prevalence of type 2 diabetes mellitus (T2DM) and obesity...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Liver Hepatocytes SREBP1 Lipogenesis NAFLD The transcription factor sterol regulatory element-binding protein (SREBP) 1 was recognized as the master regulator...

... a potential link between miRNAs and nonalcoholic fatty liver disease (NAFLD). Methods: Sprague-Dawley rats fed a high-fat diet (HFD) were used to establish a rat model of NAFLD. The miRNA expression profile of liver tissues was evaluated using Illumina HiSeq deep sequencing. Selected miRNAs were...