...Bo Pang; Fei Zhao; Yang Zhou; Bin He; Wei Huang; Fan Zhang; Yong-Gui Long; Xi Xia; Mao-Lin Liu; Yun-Han Jiang Background/Aims: Patients with myocardial infarction and hypoxemia require supplemental oxygen. However, the current therapeutic paradigm is contradicted by several recent studies in which...

...Fang He; Huibin Liu; Jing Guo; Di Yang; Yang Yu; Jie Yu; Xiuqing Yan; Juan Hu; Zhimin Du Background/Aims: MicroRNAs play an important role in regulating myocardial infarction (MI)-induced cardiac injury. MicroRNA-124 (miR-124) plays a vital role in regulating cellular proliferation, differentiation...

...Rebecca M. Parodi-Rullán; Jadira Soto-Prado; Jesús Vega-Lugo; Xavier Chapa-Dubocq; Sara I. Díaz-Cordero; Sabzali Javadov Background/Aims: The mitochondrial permeability transition pore opening plays a critical role in the pathogenesis of myocardial infarction. Inhibition of cyclophilin-D (CyP-D...

...Franziska Wittmann; Adrian Türkcan; Ulrike Baranyi; Eva Eichmair; Günther Laufer; David Bernhard; Barbara Messner Background/Aims: Clinical studies have reported a better outcome of smokers after myocardial infarction compared to non-smokers. The data are controversial, as some clinical studies did...

...) suppresses arrhythmic activity and minimizes cardiomyocyte injury. However, how VNS affects angiogenesis/arteriogenesis in infarcted hearts, is poorly understood. Methods: Myocardial infarction (MI) was achieved by ligation of the left anterior descending coronary artery (LAD) in rats. 7 days after LAD...

...Yuanyuan Cheng; Chuanbin Yang; Dan Luo; Xuechen Li; X. Chris Le; Jianhui Rong Background/Aims: Macrophages exhibit dynamic pro-inflammatory and resolving activities in myocardial infarction. The present study investigated whether caffeic acid derivatives could induce macrophage polarization towards...

...Wei Li; Yaojun Lu; Ruijuan Han; Qiang Yue; Xiurong Song; Fei Wang; Rina Wu; Feng Hou; Liu Yang; Lijuan Xu; Ruiping Zhao; Jiang Hu Background/Aims: The transplantation of cardiac progenitor cells (CPCs) improves neovascularization and left ventricular function after myocardial infarction (MI...

.... Methods: An ischemic cardiomyopathy model was reproduced with myocardial infarction (MI) in adult Sprague–Dawley male rats. The RDN/Sham-RDN procedure was performed at 2 weeks after MI. Sham-MI and sham-RDN rats served as the control group. At 4 weeks after RDN, programmed electrical stimulation (PES...

...Xiaoxiao Liu; Yifeng Xu; Yunfei Deng; Hongli Li Background/Aims: Percutaneous coronary intervention reduces acute myocardial infarction (MI)-induced mortality to a great extent, but effective treatments for MI-induced cardiac fibrosis and heart failure are still lacking. MicroRNAs (miRNAs) play...

...=29), or overexpression (n=29), and corresponding controls, were randomized into four groups: sham MI (myocardial infarction) +sham STNx (subtotal nephrectomy); MI+sham STNx; sham MI+STNx; and MI+STNx. To establish the CRS model, subtotal nephrectomy (5/6 nephrectomy, SNTx) and myocardial infarction...

... myocardial infarction and in neonatal rat CFs pretreated with angiotensin II. miR-22 overexpression increased CFs proliferation, and collagen and α-smooth muscle actin levels in CFs, while the knockdown of endogenous miR-22 decreased CFs numbers. Conclusions: Our findings demonstrate that miR-22 accelerates...

...Rui-Fang Chi; Jia-Pu Wang; Ke Wang; Xiao-Li Zhang; Yue-An Zhang; Yu-Ming Kang; Xue-Bin Han; Bao Li; Fu-Zhong Qin; Bian-Ai Fan Background/Aims: The alterations in myocyte autophagy after myocardial infarction (MI) and the underlying mechanisms have not been fully understood. In this study, we...

... parameters, we randomized male Sprague-Dawley rats into myocardial infarction (MI) or sham operation (SO) groups. CCK expression levels were assessed by western blotting, immunohistochemistry, real-time polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay (ELISA) at different time points (2...

... patients were tracked for course of left ventricular ejection fraction (LVEF), all-cause death (ACD), and myocardial infarction (MI) for 360 days after study inclusion. Results: Platelet HMGB1 expression did not significantly differ between stable CAD, unstable CAD, non-ST segment elevation myocardial...

...Jinxia Yuan; Hongtao Chen; Dawei Ge; Yu Xu; Haihua Xu; Yang Yang; Ming Gu; Yuhe Zhou; Jingdong Zhu; Ting Ge; Qun Chen; Yue Gao; Yanqing Wang; Xiaowei Li; Yanfang Zhao Background/Aims: Cardiac fibrosis after myocardial infarction (MI) has been identified as an important factor in the deterioration...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cardiogenic shock Cangrelor P2Y 12 -receptor inhibitor Platelet aggregation Percutaneous coronary intervention Myocardial infarction Deutsche...

...Yuan Hong; Huaming Cao; Qiang Wang; Jianlin Ye; Lijun Sui; Jinhua Feng; Xiaojun Cai; Huizhu Song; Xiuhong Zhang; Xichuang Chen Background/Aims: Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure, but the mechanisms undelying...

... regulating CSC proliferation and differentiation in the aged heart remained elusive. Necroptosis, a type of regulated cell death, has recently been shown to occur following myocardial infarction (MI); however, its effect on c-kit + CSCs remains unknown. We investigated the effects of hepatocyte growth factor...

... administration of STZ ( P < 0.05) as compared with respective control rats and CHF rats with IBD. This table also shows infarct size of six groups of rats. On the basis on the prior study indicating that 30% to 50% of myocardial infarct of the left ventricle corresponds to a scar area of 70 to 130 mm 2 [ 8...

...Xiang Li; Dong Han; Zuhong Tian; Beilei Gao; Miaomiao Fan; Congye Li; Xiujuan Li; Yabin Wang; Sai Ma; Feng Cao Aims: Myocardial interstitial fibrosis is a major histologic landmark resulting in cardiac dysfunction after myocardial infarction (MI). Activation of cannabinoid receptor type II (CB2...