...Lisi Zeng; Quanxing Liao; Zhaowei Zou; Yuefeng Wen; Jingshu Wang; Chang Liu; Qingjun He; Nuoqing Weng; Judeng Zeng; Hongsheng Tang; Runya Fang; Ziying Lei; Zhen Tang; Xianzi Yang; Shuzhong Cui Background/Aims: The development of multidrug resistance (MDR), which results in disease recurrence...

...Yingyu Chen; Donghui Gan; Qinghua Huang; Xiaofeng Luo; Donghong Lin; Jianda Hu Background/Aims: Acute myeloid leukemia (AML) remains a hematologic malignancy with poor survival and a high risk of relapse, which is mainly caused by the emergence of multidrug resistance (MDR). The identification...

...Liang Chang; Zhuang Hu; Zhenyu Zhou; Hui Zhang Background/Aims: Long non-coding RNAs (LncRNAs) have been validated to be pivotal mediators in multidrug resistance (MDR) of various cancers. This study aims to explore the roles and molecular mechanisms of linc00518 implicated in chemoresistance...

... site, and the natural coumarin ring in SKLB060 enables reversible binding. Conclusions: These results reveal that SKLB060 is a powerful and reversible microtubule inhibitor that binds to the colchicine site and is effective in multidrug-resistant cell lines. [email protected] 11 12...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Voruciclib ATP-binding cassette transporters ABCB1 ABCG2 Multidrug resistance National Institutes of Health (NIH) 10.13039/100000002...

...Jing Zheng; Tetsuya Asakawa; Yingyu Chen; Zhihong Zheng; Buyuan Chen; Minhui Lin; Tingbo Liu; Jianda Hu Background/Aims: The present study was designed to investigate the expression of multidrug resistance (MDR)-related genes, verify the synergistic effects of baicalin and Adriamycin (ADM...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Agonists P2X7R Purinergic Receptors Multidrug Resistance Tuberculosis Tuberculosis (TB) is a chronic...

...Chuanhui Yu; George Argyropoulos; Yan Zhang; Abba J. Kastin; Hung Hsuchou; Weihong Pan Background/aims: Although it is known that drug delivery across the blood-brain barrier (BBB) may be hampered by efflux transport activity of the multidrug resistance (mdr) gene product P-glycoprotein...

...Julie K. Horton; Carlos G. Vanoye; Luis Reuss It has been proposed that P glycoprotein (Pgp) expression is associated with swelling-activated Cl – currents in multidrug-resistant cells. The Pgp substrate vinblastine and the modulator verapamil produced a reversible concentration-dependent block...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Multidrug resistance P-glycoprotein Intracellular pH Acidification...