... of ERRα in regulating eNOS in this experimental setting, we treated ECs with ERRα inhibitor and found a decrement of total-eNOS and p-eNOS. On the contrary, overexpression of ERRα increased the levels of total-eNOS and p-eNOS. Meanwhile, parkin overexpression induced mitochondrial dysfunction and cell...

..., instructions or products referred to in the content or advertisements. Nonalcoholic steatohepatitis ShenFu preparation Palmitic acid Nox4 Mitochondrial dysfunction Cytokines Apoptosis Nonalcoholic steatohepatitis (NASH), a common liver disease throughout the world, is characterized by micro...

...)-induced autophagy as evidenced by light chain 3 (LC3) accumulation and p62 degration. Either treatment with FOXO1 siRNA or resveratrol, a sirt1 agonist, inhibited autophagic flux, resulting in oxidative stress, mitochondrial dysfunction (MtD) and apoptosis in QBC939 cells, which were attenuated...

... maturation Sperm chromatin decondensation Heparan sulfate Mitochondrial dysfunction Glutathione Open chromatin state Oocyte maturation is a complex, distinct and linked process that includes both nuclear and cytoplasmic maturation [ 1, 2 ]. Nuclear maturation and meiotic division involve...

... function remains largely unknown. We have recently reported that FAM3A exerts protective effects against oxidative stress and mitochondrial dysfunction in HT22 cells. Methods: Here, we investigated the protective effects of FAM3A using a glutamate-induced neuronal injury model in nerve growth factor (NGF...

...Wei Ding; Tingyan Liu; Xiao Bi; Zhiling Zhang Background/Aims: Growing evidence suggests mitochondrial dysfunction (MtD) and the Nlrp3 inflammasome play critical roles in chronic kidney disease (CKD) progression. We previously reported that Aldosterone (Aldo)-induced renal injury in vitro...

...Liu-Long Zhu; Mao-Qiang Li; Fan He; Shao-Bo Zhou; Wu Jiang Background/Aims: Spinal cord injury (SCI) is a common and devastating disease, which results in systemic inflammatory response syndrome and secondary lung injury. Mitochondrial dysfunction and inflammation are closely related to lung injury...

... with the inhibition of mitochondrial dysfunction as indicated by decreases in the MMP collapse, cytochrome c synthesis and mitochondrial ATP release. In addition, allicin attenuated the LPS-induced inflammatory responses, including endothelial cell adhesion and TNF-α and IL-8 production. Furthermore, allicin...

... observed that FoxO3a increased BNIP3L gene promoter activity. As expected, overexpression of BNIP3L in H9C2 cardiomyoblast cells reduced the cardioprotection of FGF-2 in H 2 O 2 -induced necrosis and mitochondrial dysfunction. Conclusions: The present data suggest that FGF-2 protects against H 2 O 2...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Didymin Mitochondrial dysfunction ERK/MAPK pathway PI3K/Akt pathway...

... with mitochondrial dysfunction and activation of the intrinsic mitochondrial pathway, which was dependent on the induction of the pro-apoptotic protein Bax. In addition, 4EGI-1 treatment triggered ER stress, which was evidenced by morphological changes of ER lumen and ER calcium release, as well as the dose...

... control. Knockdown of CGI-58 in RAW264.7 cells aggravated LPS-induced inflammation and mitochondrial dysfunction. CGI-58 overexpression and silencing in macrophages induced and inhibited PPARγ expression and activity, respectively. Most importantly, the PPARγ-specific agonist rosiglitazone significantly...

...Hao Liu; Ping Mao; Jia Wang; Tuo Wang; Chang-Hou Xie Background: Parkinson disease (PD) is a common adult-onset neurodegenerative disorder, and PD related neuronal injury is associated with oxidative stress and mitochondrial dysfunction. Allicin, the main biologically active compound derived from...

...Haider Raza; Annie John; Frank Christopher Howarth Background/Aims: The Zucker diabetic fatty (ZDF, FA/FA) rat is a genetic model of type 2 diabetes, characterized by insulin resistance with progressive metabolic syndrome. We have previously demonstrated mitochondrial dysfunction and oxidative...

... with oxidative stress and mitochondrial dysfunction. Thus, these results might have implications in understanding the etiology and pathology of diabesity. 11 11 2013 5 12 2013 The Zucker diabetic fatty (ZDF, FA/FA) rat is an experimental model of type 2 diabetes caused by an inherited insulin...

... reduction in mitochondrial membrane potential, increased in caspase-3 activity and associated loss in cell viability in Ws-CER-treated cells. Conclusion: Based on these data we conclude that ceramide-induced Nox2-mediated oxidative stress couples mitochondrial dysfunction to loss in cell viability...

...Na Chen; Yi-Ping Leng; Wen-Juan Xu; Jian-Dong Luo; Min-Sheng Chen; Yan Xiong Aims: Mitochondrial dysfunction plays important roles in the development of diabetes. Elevated nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) has been shown to be closely related to diabetes...

... chain and are possibly involved in the protection against free radical production. Mitochondrial dysfunction is involved in the pathogenesis of colon cancer for which UCP2 has been proposed as a potential therapeutic target. The object of this study was to investigate the possible effects...