... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Shengmai San Diabetic cardiomyopathy Mitochondria Mice Peroxisome proliferator...

... of hypertrophic marker genes and other genes were examined by quantitative real time PCR. Structural as well as functional remodeling of the mitochondria were evaluated by immunofluorescence (F-actin and COX-I), live cell imaging microscopy (JC-I, mitotracker), mitochondrial complex V activity, MPTP activity...

... nm using a Leica EM UC7 ultra microtome. The ultrathin sections were stained with uranium-citric acid and examined using an electron microscope (H-7650; Hitachi, Tokyo, Japan). Mitochondria were extracted from the right ischemic cortices using a Tissue Mitochondria Isolation Kit (GENMED...

... biogenesis in pig preadipocytes. (A) The morphology and number of mitochondria were observed by transmission electron microscopy. The arrows show some representative mitochondria. Fig. a-f represent pig preadipocytes transfected with pcDNA3.1 (+), pcDNA3.1 (+)-pig UCP1, pcDNA3.1 (+)-mice UCP1, pcDNA3.1...

...Elena Silvestri; Assunta Lombardi; Maria Coppola; Alessandra Gentile; Federica Cioffi; Rosalba Senese; Fernando Goglia; Antonia Lanni; Maria Moreno; Pieter de Lange Background/Aims: Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3’-triiodo-L-tyronine (T3) affect energy metabolism having mitochondria...

... Mitochondria Myelocytic differentiation Unfolded protein response Protein synthesis occurs in ribosomes present in cells. Following production, these proteins are transported into the endoplasmic reticulum (ER) where they are folded into their tertiary structure. When misfolded proteins...

... to in the content or advertisements. Rapid electrical stimulation HiPSC-CMs Calcium homeostasis Mitochondria Apoptosis CaMKII Tachycardia is the most common arrhythmia, which can cause many negative outcomes, including heart failure or even sudden cardiac death (SCD) in some patients [ 1...

... of the Annexin V-FITC/PI analysis permitted to observe the cell death triggered by FPKc; DNA damage and cell cycle arrest were detected by flow cytometry; Rhodamine 123 (RH123) and Cytochrome C were used as dyes to investigate the alterations of the mitochondria. In-vivo tumor inhibition and mice survival time...

..., methods, instructions or products referred to in the content or advertisements. LncRNA UCA1 MiR-195 ARL2 Mitochondria Bladder cancer Bladder cancer (BC) is one of the most common malignant cancers of the urinary system in China, and its incidence and mortality rates have increased...

... experiments indicated that ectopic expression of ZNF23 induced cell apoptosis by activation of caspase-3, p27, p53 expression and down-regulation of Bcl-2 through mitochondria-dependent pathway. Conclusions: Decreased ZNF23 was contributed to melanoma progression and poor survival with mitochondria-dependent...

... AβO-induced learning and memory dysfunction in mice and it may be a potential candidate in AD therapy. [email protected] 3 04 2017 15 06 2017 25 8 2017 Alzheimer’s disease Honokiol Apoptosis Mitochondria NF-κB Dementia is a kind of central nervous system (CNS...

... and CYCD. In addition, Zn-enriched melanocytes exhibit enhanced mitochondrial biogenesis, with individual mitochondria possessing stabilized mitochondrial membrane potential as well as showing elevated ATP and superoxide levels. Moreover, upon external exposure, Zn enters lysosomes/melanosomes...

... contained culture medium. After 12 h, cells were split into different groups. Each well was washed twice with 1 ml of 37°C preheated test mitochondria, and 500 µl of mitochondrial testing liquid were added. Then, the plates were cultured in a CO 2 -free incubator for 1 h. A probe card was used to add 1 ml...

..., instructions or products referred to in the content or advertisements. H9c2 Autophagy Cathepsin B Mitochondria Apoptosis Atg5 LC3 AIF Chronic myeloid leukemia (CML), a very common hematological malignity, is predominately caused by a reciprocal chromosomal translocation between chromosome...

..., are used for the treatment of macular degeneration. Here we examined the involvement of nitric oxide (NO), mitochondria function and of apoptosis/autophagy in their antioxidant effects in human retinal pigment epithelium cells (RPE). Methods: RPE were exposed to Ranibizumab/Aflibercept in the absence...

... viability Estrogenic receptors Mitochondria Peroxidation Oxidative stress is a common pathogenic factor in most liver diseases, including chronic hepatitis C virus (HCV) infection, as well as alcoholic and non-alcoholic fatty liver disease [ 1-3 ]. Parenchymal cells, mainly represented...

... the morphological and ultrastructural damage of neurons (especially mitochondria) after I/R injury. EE treatment reduced the neuronal apoptosis, increased B cell lymphoma/leukemia-2 (Bcl-2) protein levels while decreased Bcl-2-associated X protein (Bax), cytochrome c , caspase-3 expressions and Bax/Bcl-2 ratio...

... a promising mechanistic framework for MLN9708/2238 in OS treatment, supporting its clinical development. [email protected] 10 11 2016 12 12 2016 27 1 2017 Osteosarcoma (OS) Protein homeostasis Proteasome Proteasome inhibitor MLN9708/2238 Mitochondria Apoptosis Cell...

... O exchange technique to study suspensions of mitochondria freshly isolated from rat livers. The mitochondria were functionally and morphologically in excellent condition. Results: The intramitochondrial CA activity was exclusively localized in the matrix. P M,CO2 of the inner mitochondrial membrane...

... ATP levels were measured using single cell fluorescence microscopy and respective genetically-encoded sensors. Mitochondria-ER junctions were analyzed applying super-resolution SIM and ImageJ-based image analysis. Results: Resveratrol and piceatannol selectively trigger death in cancer but not somatic...