...Na Ta; Xiaoyi Huang; Kailian Zheng; Yunshuo Zhang; Yisha Gao; Lulu Deng; Bingbing Zhang; Hui Jiang; Jianming Zheng Background/Aims: MicroRNAs (miRNAs) are a group of non-coding RNAs that play diverse roles in pancreatic carcinogenesis. In pancreatic ductal adenocarcinoma (PDAC), NF-kB...

...Zhonghu Li; Yang Tao; Xiaoya Wang; Peng Jiang; Jie Li; Minjie Peng; Xi Zhang; Kai Chen; Hui Liu; Ping Zhen; Jin Zhu; Xiangde Liu; Xiangde Liu Background/Aims: MicroRNAs (miRNAs) or exosomes have recently been shown to play vital regulatory or communication roles in cancer biology. However...

... lead to distant metastases. MicroRNAs (miRNAs) have been suggested to affect radiotherapy in lung cancer. Methods: miRNA Next-Generation Sequencing was performed to investigate the effects of irradiation on the miRNA profile of lung cancer A549 cells. The functions of identified miRNA on the radiation...

... and progression of a variety of cancers including breast cancer. However, the underlying mechanisms remain largely unknown. Methods: Here, we compared the expression profiles of mRNAs, lncRNAs and miRNAs between 111 TNBC tissues and 104 non-cancerous tissues utilizing RNA-Seq Data from The Cancer Genome Atlas...

...Guomiao Zhao; Yaru Fu; Zhifang Su; Rongling wu Background/Aims: Long non-coding RNAs (lncRNAs) act as competing endogenous RNAs (ceRNAs) to compete for microRNAs (miRNAs) in cancer metastasis. Head and neck squamous cell carcinoma (HNSCC) is one of the most common human cancers and rare biomarkers...

... that miR-191 is a potential target of CCA therapy. MicroRNAs (miRNAs) are 20 to 25 nucleotide-long non-coding RNAs transcripts that negatively regulate gene expression by directly binding to the 3′-UTR of target mRNA [ 14 ]. Some studies have concluded that over 60% of human genes are regulated...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. miRNA miR-146a CADM2 Hypoxia...

... and tumor progression of HCC via the mechanism of competing endogenous RNAs (ceRNAs). Methods: Here, we systematically investigated the expression landscape and clinical prognostic value of lncRNAs, micorRNAs (miRNAs), and mRNAs from The Cancer Genome Atlas. Differentially expressed RNAs were submitted...

...-789C1.1/miR-5003/E-cadherin axis, which could be a promising therapeutic target for GC. [email protected] Gastric cancer LncRNA MiRNA E-cadherin EMT Gastric cancer is one of the most common malignancies and the second leading cause of cancer-related death worldwide...

.... Bioinformatics MTHFR Outcome Homocysteine MiRNA Stroke is the major cause of mortality among the elderly population and a common cause of long-term disability worldwide. Furthermore, the stroke burden continues to increase, especially in developing countries such as China [ 1, 2 ]. Ischemic stroke...

...Dorota Trzybulska; Dag Eckersten; Aleksander Giwercman; Anders Christensson; Christos Tsatsanis Background/Aims: Hemodialysis implies significant alterations in the profile of serum components. microRNAs (miRNAs) are present in the human serum and are considered to target distant tissues where...

... established microRNA (miRNA) as key regulators of endothelial function. Nonetheless, the role of estrogen regulation on miRNA profile in endothelial cells is poorly understood. In this study, we aimed to determine how estrogen modulates miRNA profile in human endothelial cells and to explore the role...

...Feng Zhi; Naiyuan Shao; Lian Xue; Yuan Xu; Xuezhi Kang; Yilin Yang; Ying Xia Background/Aims: Hypoxic/ischemic injury to the liver is a frequently encountered clinical problem with limited therapeutic options. Since microRNAs (miRNAs) are involved in hypoxic/ ischemic events, and δ-opioid receptor...

... and migration. Methods: Human U251 glioma cells were used to screen the optimal GDNF concentration and treatment time to stimulate proliferation and migration. MicroRNA (MiRNA) expression profiles were detected by microarray and confirmed by real-time polymerase chain reaction (PCR). The target genes...

... prognoses. However, no significant overlap is found among signatures from different studies, indicating the necessity of signature identifications at the functional level. Methods: We performed an integrated analyses of miRNA and gene expressions to identify OC prognostic subpathways (pathway regions...

...Yu Shi; Peng Ye; Xinghua Long Background/Aims: As MCF-7 and MDA-MB-231 cells are the typical cell lines of two clinical breast tumour subtypes, the aim of the present study was to elucidate the transcriptome differences between MCF-7 and MDA-MB-231 breast cancer cell lines. Methods: The mRNA, miRNA...

... receptors is not well defined. The aim of this study was to find out whether selected dysregulated miRNAs in PDAC are responsible for the decreased level of retinoid receptors. Methods: Bioinformatics, real-time PCR, western blot analysis as well as molecular manipulation with miRNA in cells of PDAC were...

... expressed microRNAs (miRNAs) in the myocardial tissue of CME pigs, and predicted and analyzed the possible functions of their target genes. Methods: Twelve Bama mini-pigs were randomly assigned to the sham and CME group (n = 6 in each group). The two groups were compared with regard to heart function, area...

... HOTAIR stability and thus promoted HOTAIR expression. Notably, HOTAIR acted as a miRNA sponge for HuR. HuR also reinforced HOTAIR sponge activity through miRNA recruitment, thus enhancing HuR expression in turn. Finally, HuR and HOTAIR levels were positively correlated and significantly up-regulated...

...Zhuojun Zheng; Xiaodong Li; Yuandong Zhu; Weiying Gu; Xiaobao Xie; Jingting Jiang Introduction: This pooled analysis study aimed to reveal the prognostic relevance of microRNAs (miRNAs) in patients with diffuse large B-cell lymphoma (DLBCL). Materials and Methods: We examined the impact of miRNAs...