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Keywords: Mff
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Cellular Physiology and Biochemistry (2018) 48 (4): 1675–1693.
Published Online: 03 August 2018
.... At the molecular level, increased NR4A1 expression activated p53, and the latter selectively stimulated mitochondrial fission and inhibited mitophagy by modulating Mff and Parkin transcription. Excessive Mff-related mitochondrial fission caused mitochondrial oxidative stress, promoted mPTP opening, exacerbated...