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Keywords: Methylation
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Cellular Physiology and Biochemistry (2018) 51 (4): 1763–1777.
Published Online: 30 November 2018
... unclear. Here, we investigated the function and underlying mechanisms of miR-10b in human CC. Methods: Quantitative RT-PCR was used to measure miR-10b expression in CC and normal tissues, and its association with clinicopathologic features was analyzed. Methylation of CpG sites in the miR-10b promoter...
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Cellular Physiology and Biochemistry (2018) 50 (1): 277–287.
Published Online: 03 October 2018
...Rui Qin; Lu Cao; Junrong Wang; Junbao Liu Background/Aims: Aberrant localization and over-expression of Ezrin have been reported to be implicated in cervical cancer (CC). Aberrant promoter methylation of some gene families may serve as potential diagnostic biomarkers for CC. In this study, we...
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Cellular Physiology and Biochemistry (2018) 45 (5): 1840–1850.
Published Online: 28 February 2018
... promoter methylation. Results: In the established (AGS cell line) and primary human gastric cancer cells, LV-HHIP transfection increased HHIP expression and inhibited cancer cell survival and proliferation as well as cell migration and invasion. Furthermore, LV-HHIP significantly attenuated promoter...
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Cellular Physiology and Biochemistry (2018) 45 (3): 1023–1033.
Published Online: 07 February 2018
... biogenesis in adipocytes in vitro . CEBPβ was determined a transcription factor of Hoxa5 and inhibited methylation level of Hoxa5 by combining on the promoter of Hoxa5. Importantly, we found Fabp4, a known positive regulator of adipocytes differentiation, was transcriptional activation by Hoxa5. In addition...
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Cellular Physiology and Biochemistry (2018) 45 (2): 692–705.
Published Online: 31 January 2018
.... Methods: We analysed TPM2 expression and its correlation with the clinicopathological features in breast cancer. Then, we examined the influence of hypoxia on TPM2 expression and methylation status using bisulfite sequencing PCR. Furthermore, we performed TPM2-mediated migration and invasion assays...
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Cellular Physiology and Biochemistry (2017) 44 (4): 1370–1380.
Published Online: 30 November 2017
... matrix assembly and degradation, connective tissue structuring, angiogenesis, and cell migration. Multiple studies suggest that ADAMTS proteins (e.g. ADAMTS9) can act as tumor suppressors. In gastric, esophageal, and nasopharyngeal carcinomas ADAMTS9 is frequently down-regulated by promoter methylation...
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Cellular Physiology and Biochemistry (2017) 42 (6): 2430–2440.
Published Online: 21 August 2017
...Nairui An; Yu Shi; Peng Ye; Zhongya Pan; Xinghua Long Background/Aims: Numerous studies have suggested that the promoter methylation status of O6-methylguanine-DNA methyltransferase (MGMT) is significantly associated with breast cancer. However, these studies have not demonstrated consistent...
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Cellular Physiology and Biochemistry (2017) 41 (3): 973–986.
Published Online: 21 February 2017
...-5p- and miR-30c-5p-overexpressed-CP70 cells and miR-30a-5p- and miR-30c-5p-inhibited-A2780 cells were examined by CCK8 assay and apoptosis analysis using flow cytometry; targets of miR-30a/c-5p were analyzed by western blotting and luciferase reporter assay; methylation regulation of pre-miR-30a/c-5p...
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Cellular Physiology and Biochemistry (2016) 40 (6): 1433–1442.
Published Online: 20 December 2016
... that SPRY4 expression served as an independent predictor for overall survival. Using 5-aza treatment, we also observed that SPRY4 expression can be affected by DNA methylation. Further experiments revealed that overexpressed SPRY4 significantly inhibited CRC cell proliferation both in vitro and in vivo...
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Cellular Physiology and Biochemistry (2014) 34 (5): 1485–1496.
Published Online: 08 October 2014
... of osteosarcoma remains an important but unmet clinical need. Method: Quantitative real-time PCR was carried out to examine the expression of miR-23a. Methylation-specific PCR was performed to evaluate the DNA methylation status of the miR-23a promoter. Cell proliferation, migration, and invasion were examined...
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Cellular Physiology and Biochemistry (2014) 34 (4): 1216–1226.
Published Online: 25 September 2014
...Lian-Jiang Zhang; Ya-Nan Zhu; Yan Gao; Si-Yuan Liu; Bo Zhai; Chang-Hong Li; Hui-Yu Liu; Jian Chen; Bao Yuan; Li-Sheng Dai; Jia-Bao Zhang Background: MBD4 (methyl-CpG binding domain protein 4) is an important G: T glycosylase that can identify T-G mismatches. It plays a role in active demethylation...
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Cellular Physiology and Biochemistry (2013) 32 (6): 1707–1719.
Published Online: 13 December 2013
... Assay and caspase-3 activity assay were employed to evaluate apoptosis. Real-time RT-PCR and Western blot were used to quantify gene expression at mRNA and protein levels, respectively. Methylation-specific PCR was utilized to assess methylation status. Results: We found that demethylation agent 5-Aza-2...
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Cellular Physiology and Biochemistry (2013) 32 (6): 1655–1667.
Published Online: 05 December 2013
... or advertisements. 2013 miR-141 Hirschsprung's disease Methylation Migration Proliferation MicroRNAs(MiRNAs) are small, non-coding RNA molecules that are about 19-25 nucleotides long [ 1 ]. They could regulate target genes by triggering mRNA degradation or translational repression...
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Cellular Physiology and Biochemistry (2007) 20 (6): 967–976.
Published Online: 30 October 2007
...Véronique Marguerite; Myléne Beri-Dexheimer; Sandrine Ortiou; Jean-Louis Guéant; Marc Merten Background: P-glycoprotein (Pgp), produced by multidrug resistance-1 gene (mdr-1), is a main mechanism developed by cancer cells to guard against anti-cancer drugs. Alterations of DNA methylation of the mdr...