...Feng Liang; Yu-Gang Wang; Changcheng Wang Background/Aims: This study aimed at investigating the effects of metformin on the growth and metastasis of esophageal squamous cell carcinoma (ESCC) in vitro and in vivo . Methods: Two human ESCC cell lines EC9706 and Eca109 were selected and challenged...

... action in normal adult humans/primates remains unknown. Therefore, we aimed to elucidate the direct effects of two biguanides (metformin/phenformin) on the expression and secretion of all anterior pituitary hormones in two non-human primate species ( Papio anubis and Macaca fascicularis...

...Guoxing Wan; Xue Sun; Fang Li; Xuanbin Wang; Chen Li; Hongliang Li; Xianjun Yu; Fengjun Cao Background/Aims: Previous studies on the effect of metformin therapy on survival of pancreatic cancer patients obtained inconsistent findings. To reevaluate the prognostic value of metformin adjuvant...

... previous next-generation sequencing (NGS) study demonstrated the reduced expression of the regulatory α subunit of phosphatidylinositol 3-kinase (PIK3r1) in irradiated murine skin. Metformin has been reported to target the PIK3-FOXO3 pathway. In this study, we investigated the effects of metformin...

... that bypass these resistance mechanisms. Metformin is a widely prescribed antidiabetic drug with direct antitumor activity against various tumor cell lines. FTY720, also known as fingolimod, is an immune-modulating agent approved by the FDA as oral medication to treat the relapsing form of multiple sclerosis...

...Chunhua Wu; Shanhu Qiu; Xiangyun Zhu; Hao Lin; Ling Li Background/Aims: Metformin treatment is reported to be associated with a lower incidence of and mortality from pancreatic cancer (PC) in type 2 diabetes patients. Activated pancreatic stellate cells (PSCs) are key stroma cells responsible...

...). Metformin is now recommended and effective for the treatment of NAFLD. We hope the current analyses of the non-coding mRNA transcriptome will provide a better presentation of the potential roles of mRNAs and long non-coding RNAs (lncRNAs) that underlie NAFLD and metformin intervention. Methods: The present...

... cancer (NSCLC) cells through suppression of prostaglandin E2 (PGE 2 ) receptor EP4 gene and regulation of downstream signaling pathways. However, the detailed mechanism underlying this, especially in combination of metformin, a known AMPK activator, still remained to be determined. Methods: Cell...

... impairs energy metabolism of renal cells, we investigated whether this drug also affects the metabolism of cardiac cells. Methods: The cardiomyoblast cell line H9c2 was treated for 24 h with glibenclamide or metformin, a known inhibitor of the mitochondrial respiratory chain. Cell viability was evaluated...

...Xianfang Meng; Guangpin Chu; Zhihua Yang; Ping Qiu; Yue Hu; Xiaohe Chen; Wenpeng Peng; Chen Ye; Fang-Fang He; Chun Zhang Background/Aims: Metformin, the common medication for type II diabetes, has protective effects on cerebral ischemia. However, the molecular mechanisms are far from clear. Mitotic...

... Alves de Castro Prado; Camila Oliveira de Souza; Helenir Medri de Souza; Evandro José Beraldi; Paulo Cezar de Freitas Mathias Background/Aims: The objective of the current work was to test the effect of metformin on the tumor growth in rats with metabolic syndrome. Methods: We obtained pre-diabetic...

...Yunhua Xu; Shun Lu Background: Recent population studies suggest that the use of metformin is associated with reduced incidence and improved prognosis of certain cancers. Methods: In the current study, we assessed the effect of metformin on esophagus cancer cells using two cell lines (Eca-109...

... tested the effects of AMPK activators (AICAR and metformin), and compound C on AMPK phosphorylation, insulin secretion, K ATP channel currents, cell membrane potential, intracellular calcium concentration, apoptosis and cell cycle distribution of INS-1E cells under standard cell culture conditions (11 mM...

...Patthara Kongsuphol; Diane Cassidy; Francisco Romeiras; Rainer Schreiber; Anil Mehta; Karl Kunzelmann Metformin use in diabetes can cause acidosis and might be linked to pancreatitis. Here, we mechanistically focus on this relationship via a point mutation in the cystic fibrosis transmembrane...