..., CCDC43 was necessary for FOXK1- mediated EMT and metastasis in vitro and vivo. Taken together, this work identified that CCDC43 promoted EMT and was a direct transcriptional target of FOXK1 in CRC cells. Conclusion: FOXK1-CCDC43 axis might be helpful to develop the drugs for the treatment of CRC...

...Jiayong Dong; Fei Teng; Wenyuan Guo; Jinghui Yang; Guoshan Ding; Zhiren Fu Background/Aims: Long noncoding RNAs (lncRNAs) are aberrantly expressed in multiple malignant tumors involved in tumor growth and metastasis. Accumulating data show that small nucleolar RNA host gene (SNHG) 1/12/20 plays...

...Feng Liang; Yu-Gang Wang; Changcheng Wang Background/Aims: This study aimed at investigating the effects of metformin on the growth and metastasis of esophageal squamous cell carcinoma (ESCC) in vitro and in vivo . Methods: Two human ESCC cell lines EC9706 and Eca109 were selected and challenged...

...Zhaoxia Hu; Peipei Wang; Jiaxin Lin; Xingrong Zheng; Fangji Yang; Genglin Zhang; Dabiao Chen; Junqiang Xie; Zhiliang Gao; Liang Peng; Chan Xie Background/Aims: MicroRNA-197 (miR-197) has been shown to play roles in epithelialmesenchymal transition (EMT) and metastasis. The Wnt/β-catenin pathway...

...Xiaolan You; Yuanjie Wang; Jian Wu; Qinghong Liu; Dehu Chen; Dong Tang; Daorong Wang Background/Aims: Increased expression of galectin-1 (Gal-1) in gastric cancer (GC) promotes metastasis and correlates with poor prognosis. The mechanisms by which Gal-1 promotes GC metastasis remain unknown...

...-time PCR, western blotting and Co-immunoprecipitation assay. Results: DCLK1 is overexpressed in pancreatic cancer and is related to metastasis and prognosis. Knockdown of DCLK1 markedly suppressed cell growth in vitro and in vivo and also inhibited the migration and invasion of pancreatic cancer cells...

... cancer cells, especially gastric cancer. However, the effects of PepE on the metastasis of poorly-differentiated gastric cancer cells and the underlying molecular mechanisms have not been well elucidated. Methods: We evaluated PepE effects on gastric cancer cell invasion and migration in vitro via wound...

... of the tumor microenvironment, tumor hemorrhage (TH) is recognized to be involved in tumor growth and metastasis. It is known that during TH, red blood cells and platelets aggregate around tumor cells, facilitating the formation of cancer cell nests and providing protection against immune responses and shear...

... and its requirement for tumor survival has been demonstrated in glioma, lung, and prostate cancers. However, whether PFKFB4 plays a role in the tumor metastasis remains uncertain. This study explores the role of PFKFB4 in tumor metastasis and its underlying mechanisms in breast cancer cells. Methods...

...Yintao Li; Menglin Bai; Yali Xu; Weiwei Zhao; Naijia Liu; Jinming Yu Background/Aims: Non-small-cell lung carcinoma (NSCLC) is the leading cause of cancer death, with tumor metastasis being mainly responsible for lung cancer-associated mortality. Our previous studies have found that tubulin...

..., which may underline the metastasis defects caused by loss of miR-338-3p in GC. Conclusion: These data indicate that miR-338-3p functions as a tumor suppressor in GC, and that the hypermethylation status of its CpG island might be a novel potential strategy for treating GC. [email protected]...

... assays. Phosphokinase array was used to confirm the dominant signal regulated by Tip60. Tumor growth and metastasis were demonstrated in vivo using a mouse model. Results: Tip60 was notably downregulated in CCA tissues, which was associated with greater tumor size, venous invasion, and TNM stage. Down...

.... Fus LATS1/2 Hippo Hepatocellular carcinoma Metastasis Stemness The incidence rate of hepatocellular carcinoma (HCC) ranks in the sixth, and lethality ranks in the third place worldwide [ 1 ]. And there is no obvious symptoms in the early stages and HCC holds fast development and metastasis...

... of TUG1 and p53 mRNA. Results: Higher TUG1 expression in LSCC than in paired normal tumor-adjacent tissue specimens ( N = 64) was observed using quantitative real-time polymerase chain reaction. Also, high TUG1 expression was positively associated with advanced T category, worse lymph node metastasis...

... alkaloid that has multiple pharmacological activities. However, the biological functions and molecular mechanism underlying the effects of OSC on the growth and metastasis of OSCC are unclear. Methods: Nrf2 levels were determined in OSCC tissues and non-cancerous specimens by quantitative real-time PCR...

... aimed to evaluate the detailed mechanisms of invasion, migration and metastasis of NPC cells. Methods: Quantitative reverse-transcription PCR (qRT-PCR) and Western blot were used to confirm the expression levels of miR-184 and Notch2. NPC cell invasion and migration were subsequently examined using...

...Bingqing Zou; Wenjia Zhu; Hongqin Liu; Shuyi Wang; Hongguang Zhu Background/Aims: Sinonasal mucosal melanoma (SMM) is a rare but extremely aggressive disease. Interestingly, however, as lethal as SMM, a few patients could survive for over 5 years without metastasis. However, biomarkers...

...: HOXC9 expression in GC tissues and adjacent non-cancer tissues was detected by quantitative RT-PCR (qRT-PCR) and immunohistochemistry. The functional effects of HOXC9 on proliferation, metastasis and stem cell-like phenotype were evaluated by relevant experiments in GC cells. The effect of miR-26a...

...Yang Xu; Jie Xu; Yanfang Yang; Lei Zhu; Xubin Li; Weipeng Zhao Background/Aims: The chondroitin sulfate proteoglycan serglycin (SRGN), a hematopoietic cell granule proteoglycan, has been implicated in promoting tumor metastasis; however, the underlying mechanisms remain to be elucidated...

..., chronic liver disease or diabetes; assigning 2 points each for hemiplegia, moderate or severe kidney disease, diabetes with end organ damage, tumor, leukemia or lymphoma; 3 points for moderate or severe liver disease; and 6 points each for malignant tumor, metastasis or acquired immune deficiency syndrome...