... in the differentiation of MSCs into osteoblasts contributes to the impaired bone formation observed in osteoporosis. Mesenchymal stem cells (MSCs) are induced to differentiate into preosteoblasts, which are regulated by the signaling cascades initiated by the various signals, including miRNAs. miR-16-2* is a newly...

...Minchen Liu; Lu Zhang; Qingqing Zhao; Xinchi Jiang; Luyao Wu; Yulan Hu Background/Aims: Genetic modification of mesenchymal stem cells (MSCs) is an essential requirement for their use as a delivery vehicle. To achieve higher transfection efficiency and better reproducibility than previously...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mesenchymal stem cells Cardiovascular diseases Cell replacement Cardiac regeneration Stem cell modification...

...Bo Tang; Xue Li; Yuanlin Liu; Xiuhui Chen; Ximei Li; Yanan Chu; Heng Zhu; Weijiang Liu; Fenfen Xu; Fan Zhou; Yi Zhang Background/Aims: Mesenchymal stem cells (MSCs) do not readily migrate to appropriate sites, and this creates a major obstacle for their use in the treatment of graft-versus-host...

... Osteogenic differentiation Angiogenesis Mesenchymal Stem Cells Bone repair following fracture is usually a rapid and precise process. After a fracture, bone mesenchymal stem cells (BMSCs) migrate to the injured site and gradually differentiate into osteoblasts, which produce bone matrix and repair...

... potentially hamper the therapeutic effects of implanted bone marrow mesenchymal stem cells (BMSCs). This study sought to address (i) the extent of change to BMSC biological characteristics in different in vitro culture conditions and (ii) the effectiveness of permanent hypoxic culture for cell therapy...

...; Michael J. Lee; Russell R. Reid; Guillermo A. Ameer; Jennifer Moriatis Wolf; Tong-Chuan He; Wei Huang Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into several lineages including bone. Successful bone formation requires osteogenesis and angiogenesis...

.... 19549154 10.1111/j.1365-2591.2009.01577.x 2. Rafter M: Apexification: a review. Dent Traumatol 2005;21: 1-8. 15660748 10.1111/j.1600-9657.2004.00284.x 3. Huang GT, Gronthos S, Shi S: Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role...

... and matrix formation in co-culture of bone-marrow mesenchymal stem cells (BMSCs) and tendon cells (TCs). Methods: The effect of continuous passive motion (CPM) therapy on tendon-bone healing in a rabbit ACL reconstruction model was evaluated by histological analysis, biomechanical testing and gene...

... Background: BMP9 induces both osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs). Nell1 is a secretory glycoprotein with osteoinductive and anti-adipogenic activities. We investigated the role of Nell1 in BMP9-induced osteogenesis and adipogenesis in MSCs. Methods: Previously...

...Shizhu Jin; Hulun Li; Mingzi Han; Mengting Ruan; Zishuai Liu; Feifei Zhang; Chunwei Zhang; Yongsub Choi; Bingrong Liu Background/Aims: Mesenchymal stem cell (MSC) transplantation has emerged as an option for the treatment of chronic hepatic cirrhosis, while its therapeutic efficacy could...

...Beilei Hu; Songfang Chen; Ming Zou; Zhiyong He; Shengmin Shao; Baohua Liu Background: Previous studies have demonstrated that mesenchymal stem cells (MSCs) can promote the recovery of neural function after cerebral apoplexy by secreting multiple cytokines. In addition, cell factor-derived...

...Li You; Ling Pan; Lin Chen; Wensha Gu; Jinyu Chen Background/Aims: Osteoporosis is a progressive bone disease characterized by a decrease in bone mass and density, which results in an increased risk of fractures. Mesenchymal stem cells (MSCs) are progenitor cells that can differentiate...

...Hongyang Hu; Min Chen; Guangzu Dai; Guoqing Du; Xuezong Wang; Jie He; Yongfang Zhao; Dapeng Han; Yuelong Cao; Yuxin Zheng; Daofang Ding Background/Aims: Bone marrow-derived mesenchymal stem cells (MSCs) are responsible for new bone formation during adulthood. Accumulating evidences showed...

...Lizhen Liu; Qin Yu; Kaimin Hu; Binsheng Wang; Yiran Zhang; Yulin Xu; Shan Fu; Xiaohong Yu; He Huang Background/Aims: Mobilization of endogenous stem cells is an appealing strategy for cell therapy However, there is little evidence for reproducible, effective methods of mesenchymal stem cell (MSC...

...Xia-Qiu Tian; Yue-Jin Yang; Qing Li; Pei-Sen Huang; Xiang-Dong Li; Chen Jin; Kang Qi; Lei-Pei Jiang; Gui-Hao Chen Background/Aims: Poor viability of transplanted mesenchymal stem cells (MSCs) within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN...

...Yulei Gao; Yinquan Zhang; Yanghu Lu; Yi Wang; Xingrui Kou; Yi Lou; Yifan Kang Background/Aims: This study investigated the effect of silencing TOB1 (Transducer of ERBB2, 1) expression in bone marrow-derived mesenchymal stem cells (MSCs) on MSC-facilitated tendon-bone healing in a rat supraspinatus...

...Byung-Joo Lee; Dae-Woon Kang; Hee-Young Park; Ji-Sun Song; Ji-Min Kim; Jeon-Yeob Jang; Jin-Choon Lee; Soo-Geun Wang; Jin Sup Jung; Sung-Chan Shin Background/Aims: Although tonsil-mesenchymal stem cells (T-MSCs) have been studied as a new autologous or homologous source of MSCs, research on specific...

.... Conversely, silencing S100A6 expression induced the production of cleaved caspase 3, and increased early stage apoptosis. S100A6 knockdown increased osteogenic differentiation activity of mesenchymal stem cells, while S100A6 overexpression inhibited osteogenic differentiation. BMP9-induced bone formation...

...Hongyu Zhang; Li Li; Qian Dong; Yufeng Wang; Qiaoling Feng; Xinying Ou; Pengfei Zhou; Tongchuan He; Jinyong Luo Background/Aims: BMP9 is highly capable of promoting osteogenic differentiation of mesenchymal stem cells (MSCs) although the molecular mechanism involved is largely unknown. Here, we...