...-1 has been extensively studied and has been appointed a role in promoting cell growth, the function of SK-2 is controversial, and both pro-proliferative and pro-apoptotic functions have been suggested. In this study we investigated whether renal mesangial cells isolated from transgenic mice...

... by apoptosis and phagocytosis of apoptotic cells. Integrin receptors participate in the regulation of phagocytosis. In mice deficient for alpha8 integrin ( Itga8 -/-) healing of glomerulonephritis is delayed. As Itga8 is abundant in mesangial cells (MC) which are non-professional phagocytes, we hypothesized...

...Shuzhen Li; Zhenzhen Sun; Guixia Ding; Wei Gong; Jing Yu; Weiwei Xia; Songming Huang; Aihua Zhang; Yue Zhang; Zhanjun Jia Background/Aims: We previously reported that indoxyl sulfate (IS) could cause mesangial cell (MC) proliferation via a cyclooxygenase (COX)-2-dependent mechanism. However...

...Tao Ding; Wei Chen; Juan Li; Jiarong Ding; Xiaobin Mei; Haiyan Hu Background/Aims: Overproliferation of mesangial cells was believed to play an important role in the progress of diabetic nephropathy, one of the primary complications of diabetes. Hydrogen sulfide (H 2 S), a well-known and pungent...

...Dan Wang; Mei-Ping Guan; Zong-Ji Zheng; Wen-Qi Li; Fu-Ping Lyv; Ruo-Yu Pang; Yao-Ming Xue Backgroud: Diabetic nephropathy is one of the most frequent causes of end-stage renal disease and is associated with proliferation of glomerular mesangial cells (MCs) and excessive production...

... showed that α 1 -adrenoceptor (α 1 -AR) antagonists inhibit mesangial cell (MC) proliferation. However, the underlying mechanism remains unclear. Methods and Results: We found that α 1 -AR is expressed in a human mesangial cell line. The α 1 -AR agonist phenylephrine (PE) induced Ca 2+ influx as well...

..., and is deposited in the mesangium in IgAN. The biological effects of SIgA on mesangial cells are poorly understood. Methods: Deposition of SIgA in frozen renal sections from IgAN patients was detected and the association between deposition of SIgA and patients characteristics was analyzed. The biological effects...

...Aiqing Zhang; Ying Han; Bin Wang; Shanwen Li; Weihua Gan Aims: This study aimed to explore the precise mechanism and signaling pathways of mesangial cell (MC) proliferation from a new point of view considering Connexin 43 (Cx43). Methods: MC proliferation was measured by the incorporation of 3H...

... contribute to ECM accumulation in mesangial cells is unknown. The present study investigated the role and mechanism of high Pi levels in ECM accumulation in immortalized human mesangial cells (iHMCs). Methods: iHMCs were exposed to normal (0.9 mM) or increasing Pi concentrations (2.5 and 5 mM...

... and death, and inflammation. Here, we used a novel catalytic inhibitor of CerK, NVP-231, and CerK knockout cells to investigate the contribution of CerK to proliferation and inflammation in renal mesangial cells and fibroblasts. Methods: Cells were treated with NVP-231 and [ 3 H]-thymidine incorporation...

...Lucimeire N. Carvalho; Priscila C. Cristovam; Clévia S. Passos; Mirian A. Boim Background/Aims: Pregnancy is characterized by vasodilatation and increased glomerular filtration rate (GFR), despite overstimulation of the renin angiotensin system (RAS). The mesangial cells (MCs) influences GFR...

...Angel Montero; Ana M. Rodríguez-López; José Carretero; Rogelio González-Sarmiento; Alicia Rodríguez-Barbero; José M. López-Novoa The effect of verapamil, a calcium channel blocker, on endothelin-1 (ET-l)-induced mesangial cell proliferation was assayed. Rat mesangial cells (primary cultures) were...

... of an angiotensin I converting enzyme inhibitor, perindopril, on mesangial cell contraction and proliferation, and a possible role of bradykinin as a mediator of the observed effects of perindopril. Perindopril (10 –5 M) and bradykinin (10 –7 M) induced decreases in planar cell surface area, that were time...

...Ana M. Rodríguez-López; Carlos Martínez-Salgado; Nélida Eleno; Miguel Arévalo; José M. López-Novoa The purpose of this study was to examine the mechanisms of thapsigargin-induced apoptosis in rat glomerular mesangial cells and the possible involvement of nitric oxide (NO) in this process...

..., diadenosine polyphosphates, adenosine and ATP as well as platelet-derived growth factor (PDGF) on pH i regulation of cultured rat mesangial cells was examined with the pH-sensitive dye 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein. The inhibitors of Na + /H + exchange, amiloride and HOE694, blocked pH i...