... and monitor data were encrypted in a file, which was transmitted to the IT’IS Foundation via e-mail and decoded by the Foundation following data analysis. [email protected] 29 12 2017 8 05 2018 11 7 2018 Radiofrequency electromagnetic fields Melatonin Oxidative stress DNA...

...Wei Ren Chen; Hong Bin Liu; Yun Dai Chen; Yuan Sha; Qiang Ma; Ping Jun Zhu; Yang Mu Background/Aims: Melatonin has been demonstrated to protect cardiac microvascular endothelial cells (CMECs) against ischemia/reperfusion injury (IRI). Autophagy plays different roles in the heart during ischemia...

... chemotherapies including gemcitabine have failed owing to weak response and side effects. Hence novel treatment regimens are urgently needed to improve the therapeutic efficacy. In this study, we aimed to assess the anticancer activity of melatonin and sorafenib as a novel therapy against PDAC. Methods: We used...

...Wenya Ma; Fang He; Fengzhi Ding; Lai Zhang; Qi Huang; Chongwei Bi; Xiuxiu Wang; Bingjie Hua; Fan Yang; Ye Yuan; Zhenbo Han; Mengyu Jin; Tianyi Liu; Ying Yu; Benzhi Cai; Yanjie Lu; Zhimin Du Background/Aims: Melatonin possesses many biological activities such as antioxidant and anti-aging. Cardiac...

... studies linking ERS to toxicants, studies have yet to determine whether ERS is a contributing factor to busulfan-induced testicular damage. Melatonin is a well-known broad-spectrum antioxidant, anti-inflammatory and antitumour agent, but the effects of melatonin on busulfan-induced ERS in mouse testes...

...Barbora Chovancova; Sona Hudecova; Lubomira Lencesova; Petr Babula; Ingeborg Rezuchova; Adela Penesova; Marian Grman; Roman Moravcik; Michal Zeman; Olga Krizanova Background/Aims: Melatonin is a hormone transferring information about duration of darkness to the organism and is known to modulate...

...Yina Chen; Jie Zhang; Qian Zhao; Qinfen Chen; Yangjie Sun; Yin Jin; Jiansheng Wu Background/Aims: Melatonin, which is mainly secreted by the pineal gland and released into blood, has anti-inflammatory properties in acute pancreatitis. Many studies show that melatonin can relieve inflammation...

...Lifeng Liu; Ying Xu; Russel J. Reiter; Yutao Pan; Di Chen; Yangzhou Liu; Xingyu Pu; Liguo Jiang; Zengchun Li Background: In a previous study, we found that melatonin inhibits MG-63 osteosarcoma cell proliferation; however, the underlying mechanisms remain elusive. Mitogen-activated protein kinase...

...Weimin Li; Mengdi Fan; Yina Chen; Qian Zhao; Caiyun Song; Ye Yan; Yin Jin; Zhiming Huang; Chunjing Lin; Jiansheng Wu Background/Aims: Melatonin, synthesized by the pineal gland and released into the blood, appears to have antitumour properties; however, the mechanisms of its anti-cancer effects...

...Jiacheng Tan; Ying Wang; Yang Xia; Nina Zhang; Xiaomeng Sun; Ting Yu; Lin Lin Background/Aims: Dilated intercellular space (DIS) contributes to the pathophysiology of gastroesophageal reflux disease (GERD). Melatonin protects the esophageal mucosa; however, the mechanisms underlying that protection...

...-cell lung cancer (NSCLC). However, the use of TKIs in NSCLS patients with somatic EGFR mutations, particularly T790M, causes drug resistance. Thus, in the present study, we investigated overcoming resistance against the TKI gefitinib by combination treatment with melatonin in H1975 NSCLC cells...

...Jung-Woo Kang; Hong-Ik Cho; Sun-Mee Lee Background: Autophagy is a self-digestion system responsible for maintaining cellular homeostasis and interacts with reactive oxygen species produced during ischemia/reperfusion (I/R). Melatonin (MLT) is a potent and endogenous anti-oxidant that has...

... been proposed that such hypothetical action could be mediated by MF-induced effects on the cellular response to melatonin (MEL), a potentially oncostatic neurohormone. The present study investigates the response of HepG2 cells to intermittent exposure to a 50 Hz, 10 µT MF, in the presence or absence...