... with anticancer properties. However, the underlying mechanisms have not been elucidated yet. Here we report a novel mode of action of 6- and 8-prenylnaringenin (PN) on human melanoma cells: Inhibition of cellular histone deacetylases (HDACs). Methods: We performed in silico and in vitro analyses using 6-PN or 8...

...Bingqing Zou; Wenjia Zhu; Hongqin Liu; Shuyi Wang; Hongguang Zhu Background/Aims: Sinonasal mucosal melanoma (SMM) is a rare but extremely aggressive disease. Interestingly, however, as lethal as SMM, a few patients could survive for over 5 years without metastasis. However, biomarkers...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Zinc Melanocytes Mitochondria Lysosomes Melanoma Zinc (Zn) is an essential component of eukaryotic cells...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2016 CDKN2A Melanoma p16INK4A p14ARF Proliferation Migration Cellular Physiology Cell Physiol Biochem 2016;40:1367-1376 and Biochemistry DOOII::1100.1.1115599/0...

...Lei Cui; Yuejun Li; Xiaoxing Lv; Jinqing Li; Xiaolin Wang; Zhanjun Lei; Xueyong Li Background/Aims: Although microRNA-301a has been reported to function as an oncogene in many human cancers, the roles of miR-301a in malignant melanoma (MM) is unclear. The present study aims to investigate...

... is able to induce the differentiation of B16-F1 melanoma cells. However, its functional component and mechanism remain unclear and are addressed in this study. Methods and Results: CMSP ( p -hydroxycinnamaldehyde isolated from CMS) inhibited the proliferation, migration and invasiveness of B16-F1 cells...

...Lili Liang; Zhixin Zhang Background/Aims: Malignant melanoma has high metastatic potential, is highly resistant to chemotherapy, and has a poor survival rate. Gambogic acid (GA), a polyprenylated xanthone extracted from a traditional Chinese medicinal herb, has been proven to exhibit antitumor...

... tumors. The present study was designed to discuss the antitumor effect on mice with melanoma and possible involvement of the mechanism of haploidentical DLI in CB6F1 mice→CC3HF1 mice (F1→F1) mouse model. Methods: An F1→F1 haploidentical infusion model was established. CB6F1 mice (H-2b/d) bearing melanoma...