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Keywords: Macrophages
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Cellular Physiology and Biochemistry (2018) 51 (4): 1815–1829.
Published Online: 30 November 2018
... implied in many physiological processes and diseases, but the role of Nsm2 in pathogen-host interactions and mycobacterial infections has barely been studied. Methods: We investigated the role of the Nsm2/ceramide system in systemic infection of mice and murine macrophages with Mycobacterium bovis...
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Cellular Physiology and Biochemistry (2018) 46 (4): 1693–1703.
Published Online: 20 April 2018
...-mediated knockdown of ADAMTS4. The effects of ADAMTS4 in cell proliferation and invasion were determined by clone formation assay and transwell migration assay, respectively. Macrophages were depleted by liposomal clodronate in immune-competent BALB/c mice and tumor growth was analyzed. Results: ADAMTS4...
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Cellular Physiology and Biochemistry (2017) 43 (6): 2170–2184.
Published Online: 25 October 2017
... such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock syndrome. Toxins that are released from S. aureus mediate many of these effects. Here, we aimed to identify molecular mechanisms how α-toxin, a major S. aureus toxin, induces inflammation. Methods: Macrophages were isolated from the bone marrow...
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Cellular Physiology and Biochemistry (2017) 42 (4): 1635–1644.
Published Online: 24 July 2017
...Zhu-lin Luo; Jian-dong Ren; Zhu Huang; Tao Wang; Ke Xiang; Long Cheng; Li-jun Tang Background: This study aimed to investigate whether exogenous hydrogen sulfide (H 2 S) can protect the RAW264.7 macrophages against the inflammation induced by free fatty acids (FFA) by blunting NLRP3 inflammasome...
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Cellular Physiology and Biochemistry (2017) 41 (6): 2307–2318.
Published Online: 26 April 2017
...Xiao-Jian Jia; Xi Li; Feng Wang; Han-Qing Liu; Da-Jun Zhang Background/Aims: This study aimed to investigate the anti-inflammatory activity of Berbamine (BER), a bisbenzylisoquinoline alkaloid extracted from Berberis amurensis ( Xiao Bo An ), and the underlying mechanisms. Methods: Macrophages...
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Cellular Physiology and Biochemistry (2017) 41 (5): 2037–2044.
Published Online: 14 April 2017
..., and attenuated the histological signs of pulmonary injury. At 24 h post-TBI, pHBSP treatment decreased the accumulation of CD68 + macrophages in the lung and reduced the mRNA levels of TNF-α, IL-6, IL-1β and iNOS in the lung. Conclusions: We identified the protective role that pHBSP played in TBI-caused ALI...
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Cellular Physiology and Biochemistry (2017) 41 (1): 193–204.
Published Online: 23 January 2017
... the maturation and secretion of interleukin (IL)-1β and IL-18. We aimed to define the consequences of NLRP3 induction, utilizing exogenous adenosine triphosphate (ATP) as an inflammasome activator, to determine if inflammasome activation increases macrophage killing of Citrobacter rodentium and define mechanisms...
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Cellular Physiology and Biochemistry (2015) 37 (6): 2135–2142.
Published Online: 25 November 2015
...Zhongxiang Yu; Yuting Zhang; Ningyang Gao; Kuang Yong Background/Aims: Circulating monocytes/macrophages are origins of osteoclasts that mediate the development of ankylosing spondylitis (AS). Moreover, infiltrated macrophages facilitate the AS progression through production and secretion of pro...
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Cellular Physiology and Biochemistry (2015) 37 (3): 879–889.
Published Online: 18 September 2015
...Shun-Lin Qu; Wen-Jing Fan; Chi Zhang; Fang Guo; Wen-Jun Pan; Dan Han; Wei Li; Yu-Ning Zhu; Zhi-Sheng Jiang Background/Aims: Our recent data indicated that Mipu1 overexpression reduces lipid intake and CD36 expression of macrophages in the presence of oxLDL. However, the mechanism of Mipu1...
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Cellular Physiology and Biochemistry (2015) 37 (2): 419–431.
Published Online: 28 August 2015
... generated, indicating that free cholesterol produces both pro- and anti-atherosclerosis effects in macrophages. This inconsistency might stem from the examination of only select concentrations of free cholesterol. In the present study, we sought to investigate the implication of excess free cholesterol...
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Cellular Physiology and Biochemistry (2015) 35 (5): 1787–1796.
Published Online: 26 March 2015
...-established laser burn (LB)-induced experimental CNV mouse model to study the molecular mechanisms underlying the development of CNV after ocular injury. We analyzed vessel density by lectin labeling. We isolated macrophages, endothelial cells and other cell types by flow cytometry, and analyzed levels...