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Keywords: MAPK
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Journal Articles
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Cellular Physiology and Biochemistry (2018) 51 (5): 2160–2171.
Published Online: 06 December 2018
... the sensitivity of both NCI-H441 and A549 NSCLC cells to cisplatin treatment. Mechanically, as the Ras/mitogen-activated protein kinase (MAPK) pathway was aberrantly activated in NCI-H441 and A549 NSCLC cells, the overexpression of miR-202 was found to inhibit the Ras/MAPK pathway by targeting the KRas gene...
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Cellular Physiology and Biochemistry (2018) 49 (2): 512–529.
Published Online: 29 August 2018
... binding to laminin receptors. Furthermore, the proapoptotic and antimigratory activities of WT-PEDF and EEE-PEDF were found respectively regulated by differential activation of two distinct MAPK pathways, namely JNK and p38. We show that JNK and p38 phosphorylation is much higher in cells treated with EEE...
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Cellular Physiology and Biochemistry (2018) 48 (1): 75–86.
Published Online: 12 July 2018
... was estimated by echocardiographic and hemodynamic measurements, and by pathological and molecular analysis. Results: Eight weeks after aortic banding (AB), NLRP1 deficiency significantly inhibited aortic banding–induced cardiac hypertrophy, inflammation, and fibrosis. Activation of MAPK, NF-κB, and TGF-β/Smad...
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Cellular Physiology and Biochemistry (2018) 45 (6): 2444–2460.
Published Online: 15 March 2018
... effects of the combined treatment, significantly protecting the cells and indicating the involvement of high ROS generation and the MAPK pathway in the underlying molecular mechanism. Conclusion: This study provides compelling evidence that hyperthermia, in combination with BCN, is a promising therapeutic...
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Journal Articles
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Cellular Physiology and Biochemistry (2018) 44 (6): 2467–2475.
Published Online: 18 December 2017
...Renli Qi; Hong Liu; Qi Wang; Jing Wang; Feiyun Yang; Dingbiao Long; Jinxiu Huang Background/Aims: Myoblasts and muscle satellite cells have the potential to transdifferentiate into adipocytes or adipocyte-like cells. Previous studies suggest that mitogen-activated protein kinase (MAPK) is critical...
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Cellular Physiology and Biochemistry (2017) 43 (4): 1533–1546.
Published Online: 16 October 2017
... control. The mitogen-activated protein kinases (MAPKs), central signaling components that regulate essentially all stimulated cellular processes, include the extracellular signal-regulated kinases 1/2 (ERK1/2) that are extremely sensitive to extracellular cues. Anti-phospho-ERK antibodies serve...
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Cellular Physiology and Biochemistry (2017) 43 (2): 540–552.
Published Online: 20 September 2017
.... The levels of TNF-α and IL-10 were measured by ELISA while the protein expression of NF-κBp65, COX-2 and iNOS was detected by immunohistochemistry. The expression of MAPK target proteins was assessed by Western blotting. Results: CM attenuated paw edema, arthritic index and gait score along with dorsal pouch...
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Cellular Physiology and Biochemistry (2017) 42 (6): 2582–2592.
Published Online: 24 August 2017
... and in vivo . AKT and MAPK signaling pathways may contribute to the process. wanhaix1@sina.com 30 05 2016 15 06 2017 24 8 2017 © 2017 The Author(s). Published by S. Karger AG, Basel 2017 Open Access License / Drug Dosage / Disclaimer This article is licensed under the Creative...
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Cellular Physiology and Biochemistry (2017) 42 (3): 952–964.
Published Online: 27 June 2017
.... To understand the evolution of this broadly-shared pathway, we studied AP-1 regulation by MAPK signaling in a basal metazoan. Methods: Metal- stressed cnidarian Nematostella vectensis anemones were tested with kinase inhibitors and analyzed for gene expression levels and protein phosphorylation. Results: We...
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Cellular Physiology and Biochemistry (2017) 41 (6): 2307–2318.
Published Online: 26 April 2017
... neutrophils. In the mouse peritonitis model, BER significantly inhibited the activation of macrophages and exudation of neutrophils. According to analysis, BER significantly suppressed phosphorylation of NF-κB and MAPK (JNK and ERK1/2) signaling pathways in LPS-stimulated macrophages. Conclusions...
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Cellular Physiology and Biochemistry (2016) 39 (6): 2262–2274.
Published Online: 07 November 2016
...Jing Chen; Yu Chen; Yajie Chen; Zicheng Yang; Bo You; Ye Chun Ruan; Yizhi Peng Background: CFTR is implicated in cutaneous wound healing although the underlying mechanisms are not fully understood. In other cell types, CFTR is reported to regulate MAPK/ NF-κB signaling. We undertook the present...
Journal Articles
Cellular Physiology and Biochemistry (2016) 38 (6): 2247–2260.
Published Online: 19 May 2016
..., which was mediated by increased cAMP release, was involved in CMSP-induced changes in MAPK, while LPA (Lysophosphatidic acid) partially reversed CMSP-induced B16 cell differentiation. Conclusion: These results demonstrated that CMSP-induced differentiation of B16F1 cells may occur through the RhoA-MAPK...
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Cellular Physiology and Biochemistry (2016) 38 (4): 1520–1531.
Published Online: 07 April 2016
... receptor 1 (H 1 R), H 4 R, proteinase-activated receptor 2 (PAR2) or Toll-like receptor 4 (TLR4) reduced HMC-1-induced pro-inflammatory factor production and MAPK and PI3K/AKT pathway activation. Conclusions: These results imply that activated mast cells trigger microglial activation. Interactions between...
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Cellular Physiology and Biochemistry (2015) 37 (2): 793–804.
Published Online: 11 September 2015
... activity, CHSY1 expression and sGAG accumulation induced by TGF-β. Furthermore, we found that TGF-β-induced expression of CHSY1 was mediated through the activation of MAPK signaling. Moreover, we showed that silencing CHSY1 decreased sGAG accumulation in nucleus pulposus cells induced by TGF-β. Conclusion...
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Cellular Physiology and Biochemistry (2015) 36 (2): 631–641.
Published Online: 18 May 2015
... real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA). Macrophage polarization and its mechanism were evaluated by flow cytometry and western blot. Additionally, toll-like receptor 4 (TLR4) small interfering RNA and mitogen-activated protein kinase (MAPK) inhibitors...