... (PCa) remains unclear. Our previous study demonstrated that lysophosphatidic acid (LPA) enhances vascular endothelial growth factor-C (VEGF-C) expression, a lymphangiogenic factor, through activating it receptors LPA 1/3 in prostate cancer (PCa) cells. Moreover, hyperglycemia up-regulates autotaxin...

... and an elevated expression of different adipokines such as autotaxin (ATX). ATX converts lysophosphatidylcholine to lysophosphatidic acid (LPA) and acts as the main producer of extracellular LPA. This bioactive lipid regulates a broad range of physiological and pathological responses by activation of LPA...

.... To further validate HIF1α inactivation, its target gene, i.e. ZEB1, an EMT-inducing factor was found to attenuate upon SIRT1 activation. To uncover the regulatory factor governing SIRT1 expression, lysophosphatidic acid (LPA), a highly enriched oncolipid in ascites/serum of OC patients, was found to down...

... blood cells (RBCs) by lysophosphatidic acid (LPA) has been investigated by a variety of research groups. Carrying out experiments, which we described in several previous publications, we observed some discrepancies when comparing data obtained by different investigators within our research group...

... separated RBCs by age in five different fractions by centrifugation using Percoll density gradient. The intracellular Ca 2+ content and the PS exposure of RBCs with different age has been investigated after treatment with lysophosphatidic acid (LPA) as well as after activation of protein kinase C (PKC...

... homeostasis, and tumorigenesis by acting as a transcriptional co-activator. Lysophosphatidic acid (LPA) is a bioactive lipid implicated in tumorigenesis and metastasis of ovarian cancer through activation of G protein-coupled receptors. However, the involvement of TAZ in LPA-induced tumorigenesis of ovarian...

... circulation. The process of PS exposure was investigated as function of the intracellular Ca 2+ content and the activation of PKCα in human and sheep RBCs. Cells were treated with lysophosphatidic acid (LPA), 4-bromo-A23187, or phorbol-12 myristate-13 acetate (PMA) and analysed by flow cytometry, single cell...

... potential Growth factors Ion channels Tyrosine kinases Lysophosphatidic acid Signal transduction Epidermal growth factor Cell Physiol Biochem 1992;2:189-195 Wouter H. Moolenaar Kees Jalink Division of Cellular Biochemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands Membrane Potential...

...Holger Repp; Andreas Matzek; Henning Draheim; Nicole Malettke; Florian Dreyer Serum-deprived chicken embryo fibroblasts (CEFs) were stimulated by newborn calf serum (NCS), epidermal growth factor (EGF), platelet-derived growth factor AB chain heterodimer (PDGF-AB), insulin, or lysophosphatidic acid...