...Meihan Liu; Xiaochun Sun; Shaomin Shi Background/Aims: In this study, we aimed to investigate how MORC family CW-type zinc finger 2 (MORC2) affects tumor progression of lung cancer. Methods: The MORC2 level was analyzed by real-time RT-PCR and immunohistochemistry (IHC) in normal control tissues...

...Yuan Qiao; Jingtao Chen; Chao Ma; Yingmin Liu; Peitong Li; Yalin Wang; Lin Hou; Ziling Liu Background/Aims: Lung cancer is the leading cause of cancer-related deaths worldwide. The outcome of patients with non-small cell lung cancer remains poor; the 5-year survival rate for stage IV non-small cell...

...Jinhua Lu; Yazhen Zhong; Jian Chen; Xianlei Lin; Zechen Lin; Nan Wang; Shengyou Lin Background/Aims: Radiotherapy plays a critical role in lung cancer treatment. Radiation can activate transforming growth factor-β (TGF-β) signaling and induce the epithelial-mesenchymal transition (EMT), which may...

...Wei Peng; Jun Wang; Bin Shan; Zhenzi Peng; Yeping Dong; Wenwen Shi; Dan He; Yuanda Cheng; Wenyuan Zhao; Chunfang Zhang; Bin Li; Chaojun Duan Lung cancer is the leading cause of cancer-related mortality worldwide. Approximately 80% of lung cancer cases are non–small cell lung carcinoma (NSCLC...

... are not fully elucidated. In this study, we aim to investigate the effects of a novel silver complex [Ag(S 2 CN(C 2 H 5 ) 2 )] 6 (AgDT) on UPS function and its anticancer potential in non-small cell lung cancer (NSCLC). Methods: Cell viability assay (i.e., the MTS assay) and flow cytometry assay were used...

... furanocoumarin compound, on γδ T cell-mediated cytotoxicity against CD133 + lung cancer cells. Methods: CD133 + and CD133 - subgroups from A549 and PC9 lung cancer cells were sorted by using flow cytometry. The cytotoxicity of γδ T cells against cancer cells was evaluated by measuring lactate dehydrogenase...

... could counteract cisplatin-induced apoptosis. Reducing platelet levels or blocking platelet-based cytoprotection may represent new methods for improving the chemotherapeutic effect. Human pulmonary microvascular endothelial cells (HPMECs) and human lung cancer A549 and H1299 cell lines (cisplatin...

...Peng-Fei Li; Qi-Gang Zhang Background/Aims: The E3 ubiquitin ligase ITCH plays an important role in invasive and metastatic cancers. However, the role of ITCH in the progression of lung cancer has not been fully described. Methods: Real-time PCR was used to detect the expression of ITCH mRNA...

... lung cancer (NSCLC) cells are not fully understood. We attempted to clarify whether CA could enhance paclitaxel (PTX)-induced cytotoxicity in H1299 cells. Methods: First, we tested the cytotoxic effects in both H1299 cells and normal human Bease-2b cells by cell proliferation experiments. Next, we use...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Bushenshugan Formula Epithelial-mesenchymal transition Lung cancer Lung cancer is a malignant tumour that is seriously harmful to human...

... with a higher NLR and PLR (p< 0.001). The NLR and PLR were sustained in patients who obtained a CR compared with moderate or poor response patients. The lower NLR of pretreatment was independently associated with a favourable prognosis in whole patients with lung cancer (HR: 0.69, 95% CI, 0.55-0.85, p...

... with structurally modified SIO (CSIO, 5 µM) significantly inhibited cell proliferation and induced apoptosis in lung cancer cell line A549. The mitochondrial pathway, death receptor pathway and ER stress induced apoptosis were stimulated upon CSIO treatment. The administration with respective inhibitors including...

...Seong-Min Park; Eun-Young Choi; Dong-Hyuck Bae; Hyun Ahm Sohn; Seon-Young Kim; Youn-Jae Kim Background/Aims: Recent studies have revealed that many long non-coding RNAs (lncRNAs) play oncogenic or tumor-suppressive roles in various cancers. Lung cancer is the leading cause of cancer-related death...

...Jiangmin Zhao; Le Li; Qian Wang; Hongxiu Han; Qing Zhan; Ming Xu Background/Aims: Lung adenocarcinoma, a form of non-small cell lung cancer with high lethality at an advanced stage, is becoming more common in women, non- or never-smokers, and even young adults. At present, there are still...

...Mengmeng Dou; Keyan Zhu; Zhirui Fan; Yuxuan Zhang; Xiufang Chen; Xueliang Zhou; Xianfei Ding; Lifeng Li; Zhaosen Gu; Maofeng Guo; Ming Yan; Xiaoming Deng; Peihong Shen; Shuling Wang Background/Aims: In contrast to men, women have experienced a rapid increase in lung cancer mortality. Numerous...

... (CRC), medulloblastoma (MDB), and ovarian cancer. Nevertheless, little is known about its function in lung cancers. Methods: We first knocked down β-catenin by siRNA to investigate its effects on lung cancer cell proliferation, migration and apoptosis. Then we verified the interaction between β-catenin...

...Xiaoxue Bai; Lin Meng; Huijie Sun; Zhuo Li; Xiufang Zhang; Shucheng Hua Background/Aims: Lung cancer is one of the most common causes of cancer related deaths worldwide. The role of several microRNAs (miRNAs) including miR-196b in different cancers has already been established. The study was aimed...

... lncRNA on chromosome 1 (FAL1) regulates cancer progression via p21. However, the expression and mechanism of FAL1 in non-small cell lung cancer (NSCLC) still remain unclear. Methods: We detected the FAL1 level in NSCLC tissues and in established cell lines using quantitative real-time PCR and evaluated...

... activation of NF-kB (nuclear factor kappa B), which leads to expression of TNF-α (tumor necrosis factor alpha) and other cytokines. The purpose of this work is to elucidate if eHSP70 is able to evoke RAGE-dependent signaling using A549 human lung cancer cells, which constitutively express RAGE. Methods...

...Sungmin Lee; Daehoon Kim; JiHoon Kang; EunGi Kim; Wanyeon Kim; HyeSook Youn; BuHyun Youn Background/Aims: Radiotherapy is applied to patients with inoperable cancer types including advanced stage non-small cell lung cancer (NSCLC) and radioresistance functions as a critical obstacle in radiotherapy...