... of the diaphragm to expose hepatic veins. Next, blood samples were taken (in this specific order) from the left hepatic vein, hepatic portal vein, and abdominal aorta. The vessels chosen for blood sampling were selected on the basis of previous studies indicating that lungs, liver and skeletal muscle may play...

... outcomes. Alcohol-induced immune-suppression during acute inflammation (trauma) was linked to nuclear factor-kappaB (NF-ĸB). Here, we analyzed alcohol`s effects and mechanisms underlying its influence on NF-ĸB-signaling during acute inflammation in human lung epithelial cells. Methods: A549-cells were...

.... Results: Genetic knockout of SGLT1 ( Slc5a1 –/– mice) significantly compromised bacterial clearance following Listeria monocytogenes infection with significantly enhanced bacterial load in liver, spleen, kidney and lung, and significantly augmented hepatic expression of TNF-α and IL-12a. While all wild...

... or advertisements. Asthma COPD Lung SLC26A4 STAT6 Cellular Physiology Cell Physiol Biochem 2017;41:1491-1502 and Biochemistry DOOII::1100.1.1115599/0/000474077027020 Pubblliisshheeddoonnlilninee: M: Maracrhch242, 42,0210717 © 2017 The Autho©r(s2).0P1u7bTlihseheAdubthyoSr(.sK)arger AG, Basel...

... relaxation and myocardial protection.We aimed to investigate the role of H 2 S in oxidative/nitrative stress and inflammation in acute lung injury (ALI) induced by endotoxemia. Methods: Male ICR mice were divided in six groups: (1) Control group; (2) GYY4137treatment group; (3) L-NAME treatment group; (4...

...Qiang Tan; Jian Cui; Jia Huang; Zhengping Ding; Hao Lin; Xiaomin Niu; Zhiming Li; Guan Wang; Qingquan Luo; Shun Lu Background/Aims: Recurrent gene mutation has been identified by the analysis of exonic DNA from lung adenocarcinoma, but its progression has not been extensively profiled...

... of cigarette smoke extract (CSE) on 17β-estradiol (E 2 ) signaling in enzymatically-dissociated bronchial airway smooth muscle (ASM) obtained from lung samples of non-smoking female patients undergoing thoracic surgery. Results: In fura-2 loaded ASM cells, CSE increased intracellular calcium ([Ca 2+ ] i...

... Background/Aims: Inflammation is a major and critical component of the lung pathology in the hereditary disease cystic fibrosis. The molecular mechanisms of chronic inflammation in cystic fibrosis require definition. Methods: We used several genetic mouse models to test a role of iNKT cells and ceramide...

...Bettina Weber; Nancy Bader; Holger Lehnich; Andreas Simm; Rolf-Edgar Silber; Babett Bartling Background/Aims: Mechanical strain of the lung tissue is a physiological process that affects the behavior of lung cells. Since recent evidence also suggests alterations in the expression of certain genes...

... compounds Conclusion: Experimental heart failure profoundly alters the pulmonary proteome. Our results supplement the current knowledge of pulmonary stress failure by specifying its molecular fundament. Proteomics Lung Experimental heart failure © 2014 S. Karger AG, Basel 2014 Open Access...

... lipopolymeric vectors on lung function and histology in normal mice. Methods: Forty-eight BALB/c mice were randomly divided into 8 groups (6/group). All animals received intratracheal instillation of the following suspensions: polymerized [(A) 1,2-dimyristoyl- sn -glycero-3-phosphocholine (DMPC):1,2-bis...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Exocytosis Fusion Hemifusion Surfactant Alveolus Lung Type II cell Stretch Mechanotransduction ATP Cellular...

..., as an innate component of the lung’s immune system it helps maintain sterility and balance immune reactions in the distal airways. Pulmonary surfactant consists of 90% lipids and 10% protein. There are four surfactant proteins named SP-A, SP-B, SP-C, and SP-D; their distinct interactions with surfactant...

...Leland Dobbs; Meshell Johnson; Jeff Vanderbilt; Lennell Allen; Robert Gonzalez Pulmonary alveolar type I cells (TI cell) are very large (ñ5400 µm 2 in surface area) squamous cells that cover more than 98% of the internal surface area of rodent lungs. In the past, TI cells were believed to serve...

...Matthias Ochs The surfactant system of the lung has essential biophysical and immunomodulatory functions. Only at the electron microscopic level does surfactant reveal its morphological complexity - and beauty. Therefore, morphological tools are indispensible to characterize the surfactant system...

... cell and tissue specific. In the lung, alveolar epithelial cells and microvascular endothelial cells are highly sensitive to hypoxia and together orchestrate a rapid and sustained adaptive response. We examined the effect of different oxygen tensions on cell viability, glucose metabolism, key...

... was to investigate the effect of urocortin (UCN), a 40-amino-acid CRF family peptide, on degranulation and intracellular calcium of rat lung mast cells. The activation and degranulation of mast cells were observed by Toluidine blue staining and transmission electron microscope. The intracellular calcium...