... clinical applications are limited by its serious cardiac toxicity and fatal adverse effects, such as sudden cardiac death resulting from long QT syndrome (LQTS). The mechanisms of cardiac arrhythmia due to ATO exposure still need to be elucidated. Long non-coding RNAs (lncRNAs) are emerging as major...

.... Berberine hERG Arrhythmia Long QT Syndrome Endoplasmic reticulum stress response Unfolded protein response The human ether-a-go-go-related gene (hERG) encodes the α subunit of the IKr channel, which plays an essential role in phase III repolarization of the action potential. hERG channel...

... that mediate I Ks . Mutations in any of these genes cause long QT syndrome, a disorder of cardiac repolarization that predisposes individuals to lethal arrhythmias. In this review, we summarize recent studies of the biophysical and pharmacological properties of HERG and KvLQT1/minK K + channels. 22 11...