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Keywords: Liver fibrosis
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Cellular Physiology and Biochemistry (2019) 51 (6): 2814–2828.
Published Online: 13 December 2018
...Zhiqin Li; Jia Wang; Qinglei Zeng; Chunling Hu; Jiajia Zhang; Hongyan Wang; Jingya Yan; Hua Li; Zujiang Yu Background/Aims: HOTTIP is a critical modulator in human diseases including liver cancer, but its role and molecular biological mechanisms in liver fibrosis are still unclear. Methods...
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Cellular Physiology and Biochemistry (2018) 51 (3): 1389–1398.
Published Online: 27 November 2018
...Lili Zhu; Tingting Ren; Zixin Zhu; Mingliang Cheng; Qiuju Mou; Mao Mu; Yongmei Liu; Yumei Yao; Yiju Cheng; Baofang Zhang; Zhuo Cheng Background/Aims: Hepatic stellate cells (HSCs) are the primary cell type responsible for liver fibrosis. Our study proved that thymosin beta 4 (Tβ4) has anti...
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Cellular Physiology and Biochemistry (2018) 50 (5): 1711–1725.
Published Online: 01 November 2018
... in BDL-induced rodent cholestatic liver fibrosis. In addition, we showed that TC, the main component of BAs, enhanced the synthesis of CTGF/ CCN2 in AML12 and BRL hepatic cell lines. Moreover, we demonstrated that TC activated ERK, Akt, and YAP signaling in hepatocytes, but the precise roles...
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Cellular Physiology and Biochemistry (2017) 42 (5): 2030–2042.
Published Online: 11 August 2017
... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Lncrna Liver fibrosis Hepatic stellate cell Fibrosis is characterized by an excessive deposition of collagen due to an imbalance between...
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Cellular Physiology and Biochemistry (2016) 40 (6): 1637–1645.
Published Online: 23 December 2016
...Frdoos Al Fadel; Susann Fayyaz; Lukasz Japtok; Burkhard Kleuser Background/Aims: Ectopic lipid accumulation in hepatocytes has been identified as a risk factor for the progression of liver fibrosis and is strongly associated with obesity. In particular, the saturated fatty acid palmitate...
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Cellular Physiology and Biochemistry (2016) 40 (1-2): 263–276.
Published Online: 18 November 2016
... chronically develop liver fibrosis and failure [ 2,9,11,12 ]. Venous obstruction and sinusoidal congestions that are obvious in the livers of patients with RILD bring to hypoxia environment in the livers [ 13,14 ]. This injury results in the death of hepatocytes, accompanied by liver fibrosis and eventual...
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Cellular Physiology and Biochemistry (2016) 38 (4): 1544–1552.
Published Online: 14 April 2016
... that miR-125a-5p is correlated with hepatitis B virus replication and disease progression. However, little is known about the biological role and underlying mechanism of miR-125a-5p in liver fibrosis. Methods: We analyzed the level of miR-125a-5p in carbon tetrachloride-induced liver fibrosis and activated...
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Cellular Physiology and Biochemistry (2014) 34 (2): 356–367.
Published Online: 11 July 2014
... was significantly reduced during the progression of liver fibrosis. The depletion of Tβ4 significantly promoted the proliferation and migration of LX-2 cells via the activation of the PI3K/Akt signaling pathway. The pro-migratory and pro-proliferative effects of Tβ4 depletion in LX-2 cells can be counteracted...