...Hyunju Park; So-Hee Ahn; Yieun Jung; Joo Chun Yoon; Youn-Hee Choi Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes. An anti...

...Zijuan Zhang; Shuguang Sun; Caixia Du; Wei Li; Juan Zhang; Yanqin Zhu; Peilin Liu; Ying Xing Background/Aims: Alzheimer's disease (AD) is known to be related to alterations in neuronal intracellular calcium activity ([Ca 2+ ] i ). The present study revealed the distinct role of leptin in Na + /Ca 2...

.... Several studies have focused on identifying mediators of FGF21 effects. However, the identification of factors involved in FGF21 regulation is far from complete. As leptin is a potent metabolic modulator as well, we aimed at characterizing whether leptin may regulate FGF21. Methods: We investigated...

... modulate depression associated biomarkers and parallel the development of depression, obesity and diabetes. In this context, recent studies revealed new mediators of both energy homeostasis and mood changes (i.e. IGF-1, NPY, BDNF, ghrelin, leptin, CCK, GLP-1, AGE, glucose metabolism and microbiota) acting...

...Ola El-Zein; Julnar Usta; Sawsan Ibrahim Kreydiyyeh Backdround/Aims : The aim of this work was to study the effect and mechanism of action of leptin added apically, on glucose absorption, using Caco-2 cells as a model. Methods : Cells were grown on inserts and treated with leptin, at different time...

...Mercedes Nadal-Serrano; Jorge Sastre-Serra; Adamo Valle; Pilar Roca; Jordi Oliver Background/Aims: Large-scale epidemiological studies support a correlation between obesity and breast cancer in postmenopausal women. Circulating leptin levels are increased in obese and it has been suggested to play...

...Ping-Ping Wang; Xiao-Yan He; Robin Wang; Zengfang Wang; Yan-Gang Wang Background/Aims: Previous studies suggested that high leptin level might increase risk of endometrial cancer, but available data were conflicting and whether high leptin level was an independent risk factor of endometrial cancer...

...Maristella A. Landgraf; Reinaldo C. Silva; Matheus Corrêa-Costa; Meire I. Hiyane; Maria Helena C. Carvalho; Richardt G. Landgraf; Niels O.S. Câmara Background/Aims: We investigated the effects of leptin in the development of lipopolysaccharide (LPS)-induced acute lung inflammation (ALI) in lean...

... was to examine whether an increase in the expression of cGPDH and PEP-CK genes (encoding enzymes providing G3P for TAG synthesis) are associated with BMI (and fat mass) and with PPARγ mRNA level. For comparative purposes, we also measured the levels of FAT/CD36, leptin and adiponectin mRNA levels in the same...

...Hung Hsuchou; Abba J. Kastin; Pramod K. Mishra; Weihong Pan Background/Aims: Acute phase C-reactive protein (CRP), elevated in obesity and inflammation, is a major binding protein for leptin. It is thought that CRP contributes to leptin resistance by preventing leptin from crossing the blood-brain...

... and brain tissue and detected locomotion in C57BL/6 mice. The insulin-mediated desire to move was evaluated in healthy volunteers and correlated to leptin levels. Results Leptin treatment led to a significant decrease in insulin-mediated phosphorylation of the insulin receptor and Akt473 which...

... Lang Department of Physiology I, University of Tübingen, *contributed equally and thus share first authorship Key Words JAK2V617F Leptin Erythropoietin Cell volume regulation Chloride channels Abstract JAK2 (Janus kinase-2) is activated by cell shrinkage and may thus participate in cell volume...

...Adamo Valle; Jorge Sastre-Serra; Jordi Oliver; Pilar Roca Background/Aims: Obesity is associated with an increased risk of estrogen-dependent breast cancer. The adipokine leptin, whose levels are chronically increased in obese people, has been shown to stimulate ER positive cancer cell growth...

...Zohreh Hosseinzadeh; Shefalee K. Bhavsar; Mentor Sopjani; Ioana Alesutan; Ambrish Saxena; Miribane Dërmaku-Sopjani; Florian Lang The Janus-activated kinase-2 JAK2 is involved in the signaling of leptin and erythropoietin receptors and mediates neuroprotective effects of the hormones. In theory...

... Wistar rats were fasted for 0, 4, 8 and 24h and refed for 3h after 8h fasting. mRNA levels of gastric and adipose tissue (retroperitoneal, mesenteric and inguinal) leptin, and of hypothalamic NPY, AgRP, POMC, CART, leptin receptor, SOCS3 (suppressor of cytokine signaling 3) and insulin receptor were...