...Wang Ping; Hu Senyan; Gu Li; Chen Yan; Lu Long Background/Aims: Lactate is one of the products of glycolysis and is a hallmark of the Warburg effect. Glycolysis is found in tumor as well as immune cells. However, the effects of lactate on the function of tumor-infiltrating T cells (TILs) are rarely...

...Yi Zhu; Jing Wu; Shi-Ying Yuan Background/Aims: Myocardium ischemia-reperfusion (I/R) injury can be caused by imbalances in cellular metabolism. Lactate, transported by monocarboxylate transporters (MCTs), has been implicated as a mechanism in this process. The present study was designed...

...Carl-Christoph Schneider; Atesch Ateschrang; Ingmar Königsrainer; Jörg Glatzle; Sarah Bühler; Richard Schaefer; Hinnak Northoff; Alfred Königsrainer; Derek Zieker Background/Aims: Wounds, especially non-healing wounds are characterized by elevated tissue lactate concentrations. Lactate is known...

...Marena Rebekka Niewisch; Zyrafete Kuçi; Hartwig Wolburg; Mirjam Sautter; Lea Krampen; Beate Deubzer; Rupert Handgretinger; Gernot Bruchelt Many cancer cells metabolize glucose preferentially via pyruvate to lactate instead to CO 2 and H 2 O (oxidative phosphorylation) even in the presence of oxygen...

... from alanine aminotransferase (ALT) to GDH. Troglitazone (TRO) added to the Gln-Glc media further enhanced glutamate metabolism via GDH at the expense of glutamate metabolism via ALT since alanine production dropped an additional 70%. TRO reduced cell glutamate content 30% while increasing lactate...

... cells, their glucose consumption and lactate production were monitored. Furthermore, synthesis and release of ferritin by neuroblastoma cells were analysed in order to examine whether ferritin is possibly an iron source for H 2 O 2 generation. Ascorbate (0.6-5.0 mM) and H 2 O 2 (25-100 µM) were found...

... proximal tubules. In substrate competition studies for transport, we investigated the effect of PZA on 50 µM [ 14 C]-urate uptake in exchange of lactate, human brush-border membrane vesicles (BBMV) being loaded with 5 mM lactate. 1 mM PZA cis- inhibited, whereas 0.1 mM PZA cis -stimulated [ 14 C]-urate...

... increases in tetraploidy. Remarkable differences between OK gng+ and LLC-PK 1 - FBPase+ cells have been found in terms of substrate metabolism of the two gluconeogenic renal sub-strains. Cultures were incubated in culture medium containing either Na- L -lactate, Na-pyruvate or lactate/pyruvate mixtures (10...