... paralleled by almost complete relocation of p27 in the cytoplasm. Treatment of HL-1 cardiomyocytes with isoproterenol was followed by up-regulation of SGK1 expression. Moreover, isoproterenol treatment stimulated the hypertrophic response and was followed by disappearance of p27 from the nuclei, effects...

... with isoproterenol (ISO, 150 µg.kg.h -1 ) for 2 d and Rem, miR-132, and α 1c (the principal subunit of Cav1.2 channels) were measured at protein and mRNA levels with western blot and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) experiments, respectively. Ca 2+ currents and intracellular Ca...

... α- and β-adrenergic agonists on the remodeling of pulmonary extracellular matrix. Methods: Eighty rats were infused over 8-72 h with NE, phenylephrine (PE), isoproterenol (ISO) or NaCl solution. We investigated mRNA expression of collagen, matrix metalloproteinase (MMP)-2, its tissue inhibitor (TIMP...

...Srinivasan Periasamy; Fan-E Mo; Shin-Yi Chen; Chih-Ching Chang; Ming-Yie Liu Background/Aims: The protective role of sesamol and its possible action against isoproterenol-induced myocardial injury and infarction is unknown. We tested the hypothesis that sesamol’s protection against myocardial...

.... The Na + effect was neither sensitive to amiloride nor to 5-NN-dimethylamiloride (DMA), both inhibitors of the Na + /H + exchanger. Activation of the Na + /H + exchanger by isoproterenol was demonstrated by an increased Li + efflux (Li + /H + exchange mode of the Na + /H + exchanger). This effect...