... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cerebral Ischemia/Reperfusion HSPB8 Mitophagy Neuroprotection As a member of the sHSPs (small heat shock...

...) on restoring SERCA2a protein level and stability reduced by myocardial ischemia/reperfusion (I/R) injury. We verified a hypothesis that Lut protected against myocardial I/R injury by regulating SERCA2a SUMOylation. Methods: The hemodynamic data, myocardial infarct size of intact hearts, apoptotic analysis...

...Qiu Zeng; Qining Fu; Xuehu Wang; Yu Zhao; Hong Liu; Zhui Li; Fenghe Li Background/Aims: Skeletal muscle ischemia/reperfusion (I/R) injury is a common and severe disease. Sonic hedgehog (Shh) plays a critical role in post-natal skeletal muscle regeneration. In the present study, the role of Shh...

...Shasha Zhu; Tongda Xu; Yuanyuan Luo; Yingying Zhang; Haochen Xuan; Yanfeng Ma; Defeng Pan; Dongye Li; Hong Zhu Background/Aims: A major challenge for current therapeutic strategies against ischemia/reperfusion (I/R) is the lack of effective drugs. Considering luteolin enhances the activity...

...Jianbing Zhu; Kang Yao; Qian Wang; Junjie Guo; Hongtao Shi; Leilei Ma; Haibo Liu; Wei Gao; Yunzeng Zou; Junbo Ge Background: Here, we determined miR-499 involvement in the protective effect of ischemic postconditioning (IPC) against myocardial ischemia/reperfusion (I/R) injury and identified...

...Xin-Tao Wang; Ye Tian; Wen-Xiao Xu; Li-Huang Cui; Shou-Yang Xiang; Song-Cen Lü Background/Aim : Ischemia/reperfusion (I/R) injury of skeletal muscles is common pathophysiology during surgeries and the superoxide dismutase (SOD) plays a critical role in this process. SOD-modeled coordination...

...Edith Hochhauser; Eylon Lahat; Maya Sultan; Orit Pappo; Maayan Waldman; Yosef Sarne; Asher Shainberg; Mordechai Gutman; Michal Safran; Ziv Ben Ari Background/Aims: Ischemia/reperfusion (I/R) injury is the main cause of both primary graft dysfunction and primary non-function of liver allografts...

... understood. This study aimed to determine the mechanisms underlying the protective effects of GA against lethal cardiac arrhythmias induced via ischemia-reperfusion in rat hearts, and to examine its electropharmacological properties. Materials and Methods: Anesthetized rats were divided into control (CTL...

...Xuejing Guan; Yingying Qian; Yue Shen; Lulu Zhang; Yi Du; Huili Dai; Jiaqi Qian; Yucheng Yan Background/Aims: Autophagy is a dynamic catabolic process that maintains cellular homeostasis. Whether it plays a role in promoting cell survival or cell death in the process of renal ischemia/reperfusion...

...Hui Wu; Ming Ye; Jun Yang; Jiawang Ding; Jian Yang; Wusong Dong; Xinan Wang Background/Aims: As a vasodilatory drug used to treat angina, nicorandil has been shown to induce an infarct-limiting effect in various experimental animal models of myocardial ischemia-reperfusion (IR). There are multiple...

...Jian-Ying Zhang; Feng Wu; Xiao-Ming Gu; Zhen-Xiao Jin; Ling-Heng Kong; Yuan Zhang; Jing-Jun Zhou; Feng Gao Aims: The aim of this study was to determine whether calpain is involved in Cl - -induced myocardial ischemia/reperfusion (I/R) injury. Methods: Isolated rat hearts were subjected to either 45...

...Dong Li; Mi Liu; Tian-Qi Tao; Dan-Dan Song; Xiu-Hua Liu; Da-Zhuo Shi Aims: Opening of the mitochondrial permeability transition pore (mPTP) is a critical event during ischemia/reperfusion (I/R) injury. Recently, we showed that Panax quinquefolium saponin (PQS) alleviates apoptosis of cardiomyocytes...

...Hui-Jie Ma; Qian Li; Hui-Juan Ma; Yue Guan; Min Shi; Jing Yang; De-Pei Li; Yi Zhang Background/Aims: Chronic intermittent hypobaric hypoxia (CIHH) protects the heart against ischemia/reperfusion (I/R) injury. This study investigated the calcium homeostasis mechanism and the role of Na + /Ca 2...

... on endothelial cells has not yet been completely elucidated. Here, we investigated molecular effects of SalA on endothelial VLDL expression and barrier dysfunction under conditions of ischemia/reperfusion (IS/RP). Methods: Human umbilical vein endothelial cells (HUVECs) treated with SalA were subjected to IS/RP...

...Jung-Woo Kang; Hong-Ik Cho; Sun-Mee Lee Background: Autophagy is a self-digestion system responsible for maintaining cellular homeostasis and interacts with reactive oxygen species produced during ischemia/reperfusion (I/R). Melatonin (MLT) is a potent and endogenous anti-oxidant that has...

...Qian Li; Feng Wang; Yan-Min Zhang; Jing-Jing Zhou; Yi Zhang Background: Cannabinoid type 2 (CB2) receptor agonists can protect myocardium against ischemia/reperfusion (I/R) injury although the underlying mechanism remains unclear. Here we report the antiapoptotic effect of CB2 receptor agonist...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Sevoflurane Propofol Mitochondria Ischemia/reperfusion...

... muscle is still poorly understood. The present study was to investigate the role of QKI in ischemia/reperfusion-induced apoptosis in cardiomyocytes. Methods: A simulated ischemia/reperfusion model was established in neonatal cardiomyocytes and adult rat heart. After QKI5 or QKI6 was expressed...

...Ann-Dorit Andersen; Bo Hjorth Bentzen; Henrik Salling; Henrik Klingberg; Morten Kanneworff; Morten Grunnet; Stine F. Pedersen Background: Ischemic postconditioning (PostC), i.e. brief ischemia-reperfusion cycles before full reperfusion, is protective against cardiac ischemia/reperfusion (I/R...

... (H/R), which increased SGK1 transcript levels, SGK1 protein abundance and SGK1 phosphorylation. H/R injury further enhanced the percentage of apoptotic cells, an effect significantly blunted by prior SGK1 overexpression. In vivo renal ischemia/reperfusion (I/R) injury increased SGK1 transcript levels...