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Keywords: Invasion
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Cellular Physiology and Biochemistry (2019) 51 (6): 2547–2563.
Published Online: 11 December 2018
... immunohistochemistry, flow cytometry, western blot, EdU incorporation, luciferase, chromatin Immunoprecipitation (ChIP) and cell invasion assays. Results: The CCDC43 gene was overexpressed in human CRC. High expression of CCDC43 protein was associated with tumor progression and poor prognosis in patients with CRC...
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Cellular Physiology and Biochemistry (2018) 51 (3): 1276–1286.
Published Online: 27 November 2018
... with metformin in this study. Western blot assay was performed to detect th level of Bcl-2, Bax and Caspase-3. Scratch wound assay, transwell assay and Millicell invasion assay were used to assay the invasion and migration of EC9706 and Eca109 cells. Nude mice tumor models were used to assay the growth and lung...
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Cellular Physiology and Biochemistry (2018) 51 (2): 513–527.
Published Online: 20 November 2018
... than the corresponding non-cancerous tissues. The methylation status of CpG islands was involved in the regulation of miR-1-3p expression. miR-1-3p inhibited the bladder cancer cell proliferation, migration, and invasion by directly targeting the 3’-UTR of glutaminase. It also exerted an anti-tumor...
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Cellular Physiology and Biochemistry (2018) 50 (3): 810–822.
Published Online: 23 October 2018
... the cell proliferation, migration/invasion, and apoptosis respectively. Results: Our study explored the expression profiles of KIF2A and miR-206 in the patients with ovarian cancer. We found that overexpression of KIF2A was associated with a poor prognosis in ovarian cancer. We also found that KIF2A mRNA...
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Cellular Physiology and Biochemistry (2018) 50 (1): 92–107.
Published Online: 02 October 2018
... tissues and adjacent normal lung tissues. Patients’ prognosis was evaluated using overall survival. The prognostic role of MARCH9 was tested with univariate and multivariate analyses. To confirm the effect of MARCH9 in cell proliferation and invasion, overexpression of MARCH9 was induced in two LAC cell...
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Cellular Physiology and Biochemistry (2018) 49 (6): 2382–2395.
Published Online: 27 September 2018
... in glioblastoma invasion remain to be clarified. The aim of this study was to investigate the molecular mechanisms of NTSR1 in glioblastoma invasion. Methods: Cell migration and invasion were evaluated using wound-healing and transwell assays. Cell proliferation was detected using CCK-8. The expression of NTSR1...
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Cellular Physiology and Biochemistry (2018) 49 (4): 1564–1576.
Published Online: 17 September 2018
... aimed to evaluate the detailed mechanisms of invasion, migration and metastasis of NPC cells. Methods: Quantitative reverse-transcription PCR (qRT-PCR) and Western blot were used to confirm the expression levels of miR-184 and Notch2. NPC cell invasion and migration were subsequently examined using...
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Cellular Physiology and Biochemistry (2018) 49 (3): 911–919.
Published Online: 05 September 2018
.... This study was aimed to investigate cytotoxic effect of external qi of Yan Xin Qigong (YXQ-EQ) toward human lung adenocarcinoma A549 cells as well as its effect on signaling pathways promoting migration, invasion and epithelial-to-mesenchymal transition (EMT) in A549 cells. Methods: Cytotoxic effect of YXQ...
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Cellular Physiology and Biochemistry (2018) 49 (1): 217–225.
Published Online: 23 August 2018
...) in the development of esophageal cancer. Methods: The expression of RUNX2 in esophageal carcinoma tissues and cells was investigated by qRT-PCR. Effects of RUNX2 on cell viability, apoptosis, migration and invasion were assessed using MTT assay, flow cytometry assay/western blot analysis, and Transwell assays...
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Cellular Physiology and Biochemistry (2018) 48 (6): 2429–2440.
Published Online: 17 August 2018
... of CRC. Results: Our results indicated that SRGN overexpression was significantly associated with poor prognosis in CRC specimens. SRGN overexpression promoted CRC cell migration and invasion in vitro ; however, SRGN depletion exhibited contrasting effects. Mechanistic investigations revealed that HIF-1α...
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Cellular Physiology and Biochemistry (2018) 48 (6): 2596–2606.
Published Online: 17 August 2018
... protein level in duct carcinoma tissues. The transfection efficiency was confirmed by western blot and/or RT-qPCR assay. The proliferation of bile duct carcinoma cells was determined by MTT and colony formation assay. The invasion ability of bile duct carcinoma cells was evaluated with Transwell invasion...
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Cellular Physiology and Biochemistry (2018) 48 (4): 1556–1562.
Published Online: 02 August 2018
... was used to examine cell proliferative ability. Flow cytometry was used to examine cell cycle distribution, the scratch test was employed to examine cell migration, and Transwell migration assay (Boyden chamber) was used to study cell invasion. Results: The optimal concentrations of prodigiosin and 5-FU...
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Cellular Physiology and Biochemistry (2018) 48 (3): 1099–1111.
Published Online: 24 July 2018
.../+ mouse metastatic osteosarcomas. Accordingly, we investigated the role of ONZIN in human osteosarcoma metastasis. Methods: ONZIN function and its downstream targets were examined in osteosarcoma cell lines. Assays related to tumorigenesis and metastasis, including cell migration, invasion, clonogenic...
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Cellular Physiology and Biochemistry (2018) 47 (6): 2250–2260.
Published Online: 05 July 2018
... unknown. Methods: The expression of LPXN in bladder cancer cells and tissues was determined by real-time PCR, western blotting, and immunohistochemistry, respectively. The biological role of LPXN in bladder cancer cell proliferation, invasion, and angiogenesis was explored both in vitro and in vivo...
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