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Keywords: Insulin resistance
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Cellular Physiology and Biochemistry (2018) 51 (5): 2041–2051.
Published Online: 06 December 2018
... of circulating Alarin with insulin resistance or metabolic syndrome (MetS), however, is unknown. This study aimed to investigate the physiological role of Alarin and its association with MetS in humans. Methods: Newly diagnosed MetS patients (n=237) and age-matched healthy subjects (n=192) were recruited...
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Cellular Physiology and Biochemistry (2018) 49 (3): 1204–1220.
Published Online: 07 September 2018
... hepatosteatosis, dyslipidemia, liver dysfunction and liver insulin resistance. Pathways of glycerophospholipid metabolism, fatty acid metabolism and primary bile acid biosynthesis were involved in the therapeutic effect of GLPP on NAFLD. Detection of key enzymes revealed that GLPP reversed low expression...
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Cellular Physiology and Biochemistry (2018) 48 (5): 1901–1914.
Published Online: 09 August 2018
... the feasibility of kefir consumption to provide benefits in cardiometabolic diseases, including hypertension, vascular endothelial dysfunction, dyslipidemia and insulin resistance. Interestingly, recent studies show that mechanisms of actions of kefir in cardiometabolic diseases include recruitment of endothelial...
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Cellular Physiology and Biochemistry (2018) 45 (6): 2187–2198.
Published Online: 10 March 2018
... and homeostasis model of insulin resistance (HOMA-IR) value. Moreover, HFD-treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding protein (SREBP)-1c expression and its downstream targeting enzymes such as fatty...
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Cellular Physiology and Biochemistry (2018) 44 (5): 1896–1911.
Published Online: 08 December 2017
... of insulin sensitivity, a decrease of adiposity and a resistance to obesity, showing that myostatin can also impact on metabolism. Thus, myostatin appeared as a potential therapeutic target to treat insulin resistance. Methods: We generated transgenic mice overexpressing Gasp-1 , a myostatin inhibitor...
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Cellular Physiology and Biochemistry (2016) 40 (5): 993–1004.
Published Online: 07 December 2016
... of diabetes and diabetes-related diseases. 2-dodecyl-6-methoxycycyclohexa-2,5-1,4-dione (DMDD) has been isolated from A. carambola L. roots, and this study was carried out to investigate the potential beneficial effects of DMDD on obesity and insulin resistance induced by a high-fat diet (HFD) in mice...
Journal Articles
Cellular Physiology and Biochemistry (2016) 39 (3): 860–870.
Published Online: 09 August 2016
...Mei Wang; Yongjun Li; Kun Zhou; Guoru Zhang; Yaling Wang; Tao Liu; Yang Zhang; Anjun Guo; Yu An Background/Aims: Extensive research has explored the role of aldosterone in insulin resistance. Recent evidence suggests that the mineralocorticoid receptor (MR) mediates aldosterone-induced...
Journal Articles
Cellular Physiology and Biochemistry (2016) 38 (3): 1218–1225.
Published Online: 17 March 2016
...Mohamed Asrih; Christelle Veyrat-Durebex; Anne-Laure Poher; Jacqueline Lyautey; Françoise Rohner-Jeanrenaud; François R. Jornayvaz Background/Aims: Fibroblast growth factor 21 (FGF21), a potent metabolic regulator, has been shown to improve insulin sensitivity in animal models of insulin resistance...
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Cellular Physiology and Biochemistry (2015) 37 (4): 1315–1328.
Published Online: 22 October 2015
...Sudarshan Bhattacharjee; Nabanita Das; Ashok Mandala; Satinath Mukhopadhyay; Sib Sankar Roy Backgrounds/Aims: The lipid induced insulin resistance is a major pathophysiologic mechanism underlying glucose intolerance of varying severity. PPARα-agonists are proven as effective hypolipidemic agents...
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Cellular Physiology and Biochemistry (2015) 37 (3): 1147–1158.
Published Online: 25 September 2015
...Ewa Harasim; Tomasz Stępek; Karolina Konstantynowicz-Nowicka; Marcin Baranowski; Jan Górski; Adrian Chabowski Background/Aims: It is well documented that increased fatty acids (FA) supply causes lipid accumulation and insulin resistance in skeletal muscles. Whether the same mechanism is present...
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Cellular Physiology and Biochemistry (2015) 37 (1): 176–192.
Published Online: 20 August 2015
... in renal proximal tubular epithelial cells (in spite of which there is a simultaneous increase in bioactive chemerin, suggesting a role of TNF-α in the conversion of prochemerin to chemerin) [ 14 ]. IL1β, another pro-inflammatory cytokine that is also involved in insulin resistance, increases both chemerin...
Journal Articles
Cellular Physiology and Biochemistry (2015) 36 (6): 2357–2365.
Published Online: 27 July 2015
... of miR-499-5p were predicted by bioinformatics and then confirmed by dual luciferase reporter assay and Western blot. To establish an insulin resistance (IR) animal model, C57BL/6 mice were fed a high-fat diet (HFD). The level of miR-499-5p in the livers of HFD-fed mice was upregulated through tail vein...
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Cellular Physiology and Biochemistry (2015) 35 (4): 1253–1275.
Published Online: 11 February 2015
... studies have demonstrated that the impaired metabolism of PtdIns(3,4,5)P 3 is a prime mediator of insulin resistance associated with various metabolic diseases including obesity and diabetes. This review examines the current status of the role of PtdIns(3,4,5)P 3 signaling in the regulation of various...