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Keywords: Insulin
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Cellular Physiology and Biochemistry (2018) 51 (2): 924–937.
Published Online: 22 November 2018
... dependent on irisin-activated adenosine monophosphate-activated protein kinase (AMPK). Meanwhile, AMPK signaling mediated the protective effects of irisin on INS-1E cell insulin secretory ability and survival as well. Additionally, irisin inhibited phosphorylation of NF-κB p65 while decreasing...
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Cellular Physiology and Biochemistry (2018) 50 (1): 378–384.
Published Online: 04 October 2018
...Vladimír Štrbák Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin. High perinatal changes of the TRH gene expression and TRH concentrations in rat pancreatic islets coincide with the perinatal...
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Cellular Physiology and Biochemistry (2018) 49 (3): 1037–1047.
Published Online: 07 September 2018
... in response to H-1-2 treatment was quantified by western blotting. The blood glucose, secreted insulin and serous lipid profiles were measured with ELISA kits. Results: We consolidated that HIF1α and Sirt1 was dysregulated in T2DM patients and subjected to H-1-2 modulation. H-1-2 significantly inhibited...
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Cellular Physiology and Biochemistry (2018) 47 (1): 356–367.
Published Online: 11 May 2018
... to investigate the molecular mechanisms underlying the centrosome amplification triggered by high glucose, insulin and palmitic acid. Western blot analysis was used to quantify the level of protein and protein phosphorylation. Immunofluorescent staining was performed to detect centrosomes. ROS was quantified...
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Cellular Physiology and Biochemistry (2018) 46 (2): 727–739.
Published Online: 29 March 2018
... of the cardiovascular system in hypertension. Abnormalities in glucose metabolism and insulin action are commonly detected in hypertensive animals. Thus, potential antihypertensive drugs should be investigated with respect to modulation of glucose homeostasis. Therefore, the aim of the present study was to evaluate...
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Cellular Physiology and Biochemistry (2017) 43 (2): 870–878.
Published Online: 28 September 2017
... days, we observed the animal models for an additional 4 weeks. After body weights were measured, urinary albumin, urinary protein, SOD activity and malondialdehyde (MDA) were measured by ELISA, BCA and biochemical assay respectively . Moreover, plasma insulin was assayed by radioimmunoassay, insulin...
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Journal Articles
Cellular Physiology and Biochemistry (2016) 38 (2): 659–669.
Published Online: 08 February 2016
...Shengqiang Xia; Ying Liu; Xinming Li; Florian Thilo; Martin Tepel Background/Aims: Insulin signaling to podocytes is relevant for the function of the glomerulus. Now, we tested the hypothesis that insulin increases the surface expression of canonical transient receptor potential canonical type 6...
Journal Articles
Cellular Physiology and Biochemistry (2016) 38 (2): 558–570.
Published Online: 05 February 2016
... hypothesize that insulin acts goose hepatocellular growth by PI3K-Akt-mTOR signal pathway. Because the physiological status of liver cells in vitro is different from that in vivo , a simplified cell model in vitro was established. Methods: Goose primary hepatocytes were isolated and incubated in either...
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Cellular Physiology and Biochemistry (2015) 37 (4): 1407–1420.
Published Online: 22 October 2015
... water for 24 weeks. All rats were fed with the standard diet with or without resveratrol. Results: High-fructose diet increased plasma insulin, triglyceride and VLDL levels as well as omental weights in both genders. Long-term dietary fructose causes marked increase in body weight of males...
Journal Articles
Cellular Physiology and Biochemistry (2015) 37 (3): 1029–1043.
Published Online: 25 September 2015
..., instructions or products referred to in the content or advertisements. Nutrition Food Diet Depression Microbiota Leptin Ghrelin IGF BDNF Insulin By the year 2020, depression is projected to reach second place in the ranking of disability adjusted life years calculated for all ages...
Journal Articles
Cellular Physiology and Biochemistry (2015) 37 (1): 284–296.
Published Online: 24 August 2015
... trafficking could activate the unfolded protein response (UPR) by up-regulating the expression levels of activating transcription factor-6 (ATF-6) and the ER chaperone protein calnexin. In addition, we demonstrated that 100 nM insulin up-regulated the expression of the hERG channel and rescued the hERG...
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Journal Articles
Cellular Physiology and Biochemistry (2015) 36 (4): 1467–1479.
Published Online: 06 July 2015
... to investigate the effect of insulin on the local environment after cecal ligation and puncture (CLP) in rats. Methods: Diabetic (alloxan, 42 mg/kg i.v., 10 days) and non-diabetic (control) male Wistar rats were subjected to a two-puncture CLP procedure and 6 h later, the following analyses were performed...
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Cellular Physiology and Biochemistry (2013) 32 (5): 1403–1416.
Published Online: 28 November 2013
... by extracellular protons in the physiological pH range (i.e. pH 7.7 - 6.8) and is coupled to the production of cAMP. Methods: We examined mice lacking GPR4 and examined glucose tolerance and insulin sensitivity in young and aged mice as well as in mice fed with a high fat diet. Expression profiles of pro- and anti...