...Bo Dai; Dan Wei; Ning-ning Zheng; Zhi-hong Chi; Na Xin; Ting-xian Ma; Lan-yan Zheng; Ryo Sumi; Luning Sun Background/Aims: Inflammation plays a vital role in the etiology and pathogenesis of chronic noncommunicable diseases (NCDs), which are the leading health issues throughout the world. Our...

... of the forelimb or the posterior limb of the mouse. Microarray was performed to achieve differentiated miRNAs in the mice. The expressions of miR-544a, MCP-1, IL36B and IL17B after spinal cord injury were detected by qRT-PCR. Subsequently, miR-544a was overexpressed to observe changes in inflammation and grip...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Alpha-lipoic acid preconditioning Ischaemic postconditioning Cerebral ischaemia/reperfusion injury TLR4 Inflammation Acute cerebral infarction is the third...

... to investigate the hypothesis that miR-135a alleviates dextran sodium sulfate (DSS)-induced inflammation in colonic cells and potential mechanisms are also studied. Methods: Caco-2 and HT-29 cells in this study were treated with DSS, miR-135a mimic, and S3I-201, and then CKK-8 assay was used to test cell...

... in the expression of TLR found in blood and hypertrophied fat depots, namely decreased TLR3 in lymphocytes and inflamed adipocytes, are linked to metabolic inflammation. [email protected] 23 03 2018 16 11 2018 26 11 2018 © 2018 The Author(s). Published by S. Karger AG, Basel 2018...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Calcium dobesilate Diabetic kidney disease Inflammation Endothelial...

...Lin Wang; Shuang Pei; Linlin Han; Bin Guo; Yanfei Li; Ranran Duan; Yaobing Yao; Bohan Xue; Xuemei Chen; Yanjie Jia Background/Aims: Neurotoxic A1 astrocytes are induced by inflammation after spinal cord injury (SCI), and the inflammation-related Nuclear Factor Kappa B (NFκB) pathway may be related...

... of diabetic nephropathy (DN) during type 2 diabetes. In this pilot study we aim to assess whether miR-31 levels are modulated by the presence of DN and whether the expression of this miRNA is related to leukocyte-endothelial interactions and inflammation. Methods: Thirty-one T2D patients were enrolled...

... regulated oxidative stress marker and interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) inflammatory cytokines. Conclusion: These results show that SDAPR could be an effective dietary supplement to relieve GM-induced nephrotoxicity by improved antioxidase activity, suppressed inflammation, and inhibited...

...Yanjun Wu; Yunxiao Li; Bo Wu; Chunting Tan; Xin He; Bo Xu; Ganggang Yu; Haoyan Wang Background/Aims: β-arrestin2 has been shown to have a role in human inflammatory disease. However, the role of β-arrestin2 in cigarette smoke-induced inflammation in the lung remains unknown. The aims of this study...

... altered metabolism, mitochondrial dysfunction, oxidative stress, inflammation, cell death and extracellular matrix remodeling. Recently, pyroptosis, a type of programmed cell death related to inflammation, was proven to be activated in DCM. However, the molecular mechanisms underlying pyroptosis in DCM...

... impaired aortic cholesterol homeostasis and exacerbated hyperlipidemia and aortic inflammation, which accelerated atherosclerosis in mice. Moreover, lipid accumulation in liver, particularly total cholesterol, free cholesterol, fatty acids, and glycerol, was increased with olanzapine treatment in apoE...

... miR-136-5p or inhibited its expression. The influence of miR-136-5p overexpression and miR-136-5p silencing on inflammation was observed in vivo in an SCI rat model. The expression of IL-1β, IL-6, TNF-α, IFN-α, and related proteins (A20, IKKβ, and NF-κB) was detected. Results: In vitro studies showed...

... discovery for its relevant pharmacological properties in different pathogenic processes, including inflammation. Here, we investigated the involvement of OC in LPS-activated osteoarthritis (OA) human primary chondrocytes. Methods: Human primary chondrocytes were harvested from articular cartilage samples...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Sphingosine 1-phosphate Sphingosine 1-phosphate receptor Inflammation Bone marrow-derived monocyte/macrophage Macrophage polarization Signaling...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Spinal cord injury Chinese angelica polysaccharide apoptosis inflammation COX-1 Spinal cord injury (SCI) is a complex and devastating condition mainly induced...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chronic kidney disease Inflammation Fibrosis Connexin43 Targets of therapy Chronic kidney disease (CKD) is a major burden of public health associated with high...

...Ying Yang; Jun Yang; Xiao-wen Liu; Jia-wang Ding; Song Li; Xin Guo; Chao-jun Yang; Zhi-xin Fan; Hui-bo Wang; Qi Li; Hui-min Wang; Jian Yang Background/Aims: Micro RNAs (miRNAs) play a very important role in myocardial ischemia/ reperfusion injury (MIRI), including in inflammation, apoptosis...

...Zhiyong Weng; Yue Chi; Jing Xie; Xuefeng Liu; Jiehua Hu; Fan Yang; Lihua Li Background/Aims : Clinically, biliary obstruction is often accompanied by progressive inflammation. Dehydroandrographolide (DA) possesses anti-inflammatory properties. However, the anti-inflammatory activities of DA...

..., instructions or products referred to in the content or advertisements. Butein Osteoarthritis Autophagy Inflammation AMPK mTOR TSC2 ULK1 Osteoarthritis (OA) occurs due to irreversible degeneration of articular cartilage, remodeling of subchondral bone, and progressive pain and joint...