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Keywords: Hypoxia
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Cellular Physiology and Biochemistry (2019) 51 (6): 2972–2988.
Published Online: 14 December 2018
... target proteins were identified, some of these proteins govern key signaling associated with gap junction, focal adhesion, actin cytoskeleton rearrangement. Cortactin, one of the biggest changed phospho-protein, is a novel oxidized ATM-dependent target in response to hypoxia. Mechanically, we reveal...
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Cellular Physiology and Biochemistry (2018) 51 (2): 949–960.
Published Online: 22 November 2018
... the post-infarcted heart appears to benefit from systemic hypoxia. With this systematic review and meta-analysis, we aimed to discover whether systemic hypoxia is beneficial or detrimental to the infarcted myocardium. Methods: We conducted an electronic search of the PubMed, EMBASE, and Web of Science...
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Cellular Physiology and Biochemistry (2018) 49 (3): 1037–1047.
Published Online: 07 September 2018
... hypoxia and up-regulated Sirt1 expression in EndoC-βH1 cells. Accordingly, H-1-2 enhanced glucose-stimulation insulin secretion and improved blood glucose and lipid profiles in T2DM cells, and elevated the glucose and insulin tolerance simultaneously. Furthermore, we demonstrated that H-1-2 alleviated...
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Cellular Physiology and Biochemistry (2018) 47 (1): 302–315.
Published Online: 11 May 2018
... of excitatory transmitter release, and attenuation of disrupted neuronal transmission. During prolonged hypoxia/ischemia, however, DOR neuroprotection involves a variety of signaling pathways. More recently, our data suggest that DOR may display its neuroprotective role via the BDNF-TrkB pathway. This review...
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Cellular Physiology and Biochemistry (2018) 47 (1): 212–222.
Published Online: 10 May 2018
...Zhongju Shi; Zhijian Wei; Jiahe Li; Shiyang Yuan; Bin Pan; Fujiang Cao; Hengxing Zhou; Yan Zhang; Yao Wang; Shiwei Sun; Xiaohong Kong; Shiqing Feng Background/Aims: Neural stem cells (NSCs) reside in a hypoxic environment, and hypoxia plays an important role in their development and differentiation...
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Cellular Physiology and Biochemistry (2018) 46 (6): 2500–2507.
Published Online: 05 May 2018
... to the protein phosphatase 2C family, has a role in cell survival and apoptosis. Hypoxia-inducible factor 1α (HIF-1α) is the key transcription factor in the response to oxygen deficiency in mammals. Direct phosphorylation and dephosphorylation of HIF-1α affect its function. The present study investigated...
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Cellular Physiology and Biochemistry (2018) 46 (5): 1835–1848.
Published Online: 25 April 2018
... ischemic injury at the graft site are not well known. In this study, we aimed to determine if c-Met-activated mesenchymal stem cells (MSCs) pre-exposed to hypoxia promote therapeutic efficacy when transplanted to ischemic models, and whether c-Met interacts with cellular prion protein (PrP C ) present...
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Cellular Physiology and Biochemistry (2018) 46 (4): 1483–1492.
Published Online: 19 April 2018
...Qianqian Shi; Jian Shi; Fengbao Luo; Guanglai Song; Xiaozhou He; Ying Xia Background/Aims: Mitogen-activated protein kinases (MAPKs) are involved in the cellular response to hypoxia and their dysregulation may contribute to the progression and pathology of diverse human renal diseases. Recent...
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Cellular Physiology and Biochemistry (2018) 46 (3): 1159–1174.
Published Online: 16 April 2018
...Adolf M. Sandbichler; Bianca Jansen; Bettina A. Peer; Monika Paulitsch; Bernd Pelster; Margit Egg Background/Aims: Reduced oxygen availability, hypoxia, is frequently encountered by organisms, tissues and cells, in aquatic environments as well as in high altitude or under pathological conditions...
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Cellular Physiology and Biochemistry (2018) 46 (1): 203–212.
Published Online: 21 March 2018
...Irene Filippi; Ilaria Saltarella; Carlo Aldinucci; Fabio Carraro; Roberto Ria; Angelo Vacca; Antonella Naldini Background/Aims: Hypoxia is a powerful stimulator of angiogenesis under physiological as well as pathological conditions. Normal endothelial cells (EC), such as human umbilical vein EC...
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Cellular Physiology and Biochemistry (2018) 45 (6): 2213–2224.
Published Online: 10 March 2018
...–mesenchymal transition (EMT) was also observed after IL-11 incubation. Furthermore, IL-11 activated AKT and STAT3 in our experimental models. In addition, we observed that hypoxia induced IL-11 expression in NSCLC cells. Deferoxamine (DFX) or dimethyloxalylglycine (DMOG) induced hypoxia-inducible factor 1...
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Cellular Physiology and Biochemistry (2018) 45 (2): 692–705.
Published Online: 31 January 2018
.... Methods: We analysed TPM2 expression and its correlation with the clinicopathological features in breast cancer. Then, we examined the influence of hypoxia on TPM2 expression and methylation status using bisulfite sequencing PCR. Furthermore, we performed TPM2-mediated migration and invasion assays...
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Cellular Physiology and Biochemistry (2018) 44 (6): 2296–2309.
Published Online: 14 December 2017
... (DOR) is protective against hypoxic/ischemic injury, we asked if pharmacological activation of DOR can alter hypoxic events by regulating miRNA expression in the liver. As the first step, the present work aimed at testing the effect of DOR activation on hepatic miRNA expression in hypoxia. Methods...
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Cellular Physiology and Biochemistry (2017) 43 (6): 2457–2469.
Published Online: 31 October 2017
... the role of MEG3 in the hypoxia-induced injuries of PC12 cells. Methods: The PC12 cells were seeded and cultured under hypoxia and normoxia culture conditions. The cell viability determined by trypan blue exclusion, apoptosis using propidium iodide (PI) and fluorescein isothiocynate (FITC)-conjugated...