...Dawei Lian; Jieqing Lai; Yanjiao Wu; Lei Wang; Yongjun Chen; Yang Zhang; Krishna M. Boini; Yi Huang; Yang Chen Background/Aims: Angiotensin II (Ang II) is an octapeptide hormone that plays a significant role in mediating hypertension. Although hypertension is considered a chronic inflammatory...

... abnormalities in the development of atherosclerosis and hypertension. Myeloperoxidase (MPO) is involved in ROS modifications, triggering lipid peroxidation and aldehyde formation. However, the relationship between the entirety of the MPO reaction system and oxidative modification of serum lipoproteins...

... the feasibility of kefir consumption to provide benefits in cardiometabolic diseases, including hypertension, vascular endothelial dysfunction, dyslipidemia and insulin resistance. Interestingly, recent studies show that mechanisms of actions of kefir in cardiometabolic diseases include recruitment of endothelial...

...Hong-Bao Li; Chan-Juan Huo; Qing Su; Xiang Li; Juan Bai; Guo-Qing Zhu; Yu-Ming Kang Background/Aims: Exercise training (ExT) was associated with cardiovascular diseases including hypertension. The rostral ventrolateral medulla (RVLM) is a key region for central control of blood pressure...

...Yun-Long Zhang; Lian-Yun Zhi; Lei-Xin Zou; Chen Chen; Jie Bai; Qiu-Yue Lin; Song Lai; Lei Wang; Ying Liu; Hui-Hua Li Background/Aims: Angiotensin II (Ang II)-mediated hypertension is a major risk factor for cardiovascular diseases. Ang II induces changes in vessel structure and function through...

... of the cardiovascular system in hypertension. Abnormalities in glucose metabolism and insulin action are commonly detected in hypertensive animals. Thus, potential antihypertensive drugs should be investigated with respect to modulation of glucose homeostasis. Therefore, the aim of the present study was to evaluate...

... hypertension in the offspring, but the exact mechanisms are not clear. Renal dopamine D 1 receptor (D 1 R), regulated by G protein-coupled receptor kinase type 4 (GRK4), plays an important role in the regulation of renal sodium transport and blood pressure. In this present study, we determined if renal D 1 R...

...Yong-Ping Lu; Christoph Reichetzeder; Cornelia Prehn; Liang-Hong Yin; Chen Yun; Shufei Zeng; Chang Chu; Jerzy Adamski; Berthold Hocher Background/Aims: Impaired birth outcomes, like low birth weight, have consistently been associated with increased disease susceptibility to hypertension in later...

...Xing-Sheng Ren; Ying Tong; Li Ling; Dan Chen; Hai-Jian Sun; Hong Zhou; Xiao-Hong Qi; Qi Chen; Yue-Hua Li; Yu-Ming Kang; Guo-Qing Zhu Background/Aims: Angiotensin (Ang) II plays vital roles in vascular inflammation and remodeling in hypertension. Phenotypic transformation of vascular smooth muscle...

...Ning Zhou; Jia-Jye Lee; Shaunrick Stoll; Ben Ma; Kevin D. Costa; Hongyu Qiu Background/Aims: Our previous studies demonstrated that intrinsic aortic smooth muscle cell (VSMC) stiffening plays a pivotal role in aortic stiffening in aging and hypertension. However, the underlying molecular mechanisms...

...Qiang Li; Rongbing Jin; Hao Yu; Hongmei Lang; Yuanting Cui; Shiqiang Xiong; Fang Sun; Chengkang He; Daoyan Liu; Hongbo Jia; Xiaowei Chen; Sijiao Chen; Zhiming Zhu Background/Aims: Obesity and high salt intake are major risk factors for hypertension and cardiometabolic diseases. Obese individuals...

...Qianqian Dong; Wenjuan Xing; Feifei Su; Xiangyan Liang; Fei Tian; Feng Gao; Siwang Wang; Haifeng Zhang Aims: Obesity is a major risk for hypertension. Endothelial dysfunction contributes to increased peripheral vascular resistance and subsequent hypertension. Autophagy regulates endothelial...

...)-sensitive fluorescent probe, was used to detect intracellular ROS levels. Results: TRPM4 was mainly expressed near the plasma membrane of mesenteric artery endothelial cells, and its expression level increased in SS hypertensive rats fed a HSD. Its protein expression was significantly upregulated upon...

...He Li; Xian Liu; Zhongqiao Ren; Jinxia Gu; Yingjie Lu; Xiaoyun Wang; Lan Zhang Background/Aims: Hypertension is a major cause of stroke, and diabetes can increase incidence of this disease. We determined the role played by central angiotensin-(1-7) [Ang-(1-7)] pathway in modulating spontaneously...

... and treatment of cardiovascular diseases remain uncertain. This study investigated antihypertensive effect and underlying mechanisms of SABP vs. SM lyophilized powder (SMLP) in spontaneously hypertensive rats (SHR) and to establish the ratio of the optimal compatibility of DSS, Sal-A, Sal-B and PAL in improving...

... of hypertensive states and respiratory distresses. A review of the literature regarding the ability of some compounds (namely several known inhibitors of ion transport) to block pendrin activity revealed discordant findings. These incongruous findings may be due, in part, to the concentration of compound...

...Zhiming Zhu; Shiqiang Xiong; Daoyan Liu Hypertension is an important global public-health challenge because of its high prevalence and concomitant risks for cardiovascular and kidney diseases. More than 60% of the risk factors for hypertension are associated with metabolic disorders. Furthermore...

...Tao-Tao Li; Xiao-Yan Li; Li-Xin Jia; Jing Zhang; Wen-Mei Zhang; Yu-Lin Li; Yong-Fen Qi; Jie Du Background/Aims: Hypertension plays a critical role in the cardiac inflammation and injury. However, the mechanism of how hypertension causes the cardiac injury at a molecular level remains...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Plasma sodium Hypertension Kidney disease Glycocalyx Salt-blood-test Cardiovascular disease is the major cause of mortality in hemodialysis patients and represents almost 50% of all-cause...

... indicates that these two molecules could cooperate as an osmosensor to rapidly detect and respond to alterations in luminal fluid osmolality. 26 11 2013 18 12 2013 Pendrin Aquaporin Blood pressure Hypertension Acid-base homeostasis pH K + depletion Pendrin is a transport...