...). According to bioinformatics analysis and luciferase assay, this polymorphism could attenuate the binding of let-7f and miR-196a ( P = 0.021 and 0.019, respectively) leading to the accumulation of MTHFR and degradation of serum homocysteine, and resulting in a better IS outcome. Conclusion: This study...

...Yanyan Zhang; Yuan Zhang; Jiayu Tang; Shuang Zhao; Chen Li; Yong-Pan Huang; Minhan Yi Background/Aims: Genetic or nutritional deficiencies in homocysteine (Hcy)metabolism lead to the accumulation of Hcy and its metabolites in the blood. This can lead to hyperhomocysteinemia (HHcy), which...

... Taqman probe. The potential interaction was predicted by multiple bioinformatics analysis. The relative expression of MTHFR was detected by qRT-PCR. Further confirmation was determined by dual-luciferase assay. The plasma homocysteine levels were assayed by ELISA. Results: Cigarette smoking, alcohol...

..., and plasma homocysteine levels were assayed by ELISA. Results: Cigarette smoking, alcohol consumption, diabetes, hypertension (all P <0.001), low levels of serum high-density lipoprotein-C (P = 0.01), and high levels of serum low-density lipoprotein-C (P = 0.005) were associated with an increased risk...

... plasma homocysteine (Hcy) correlates with CVD while selenium supplementation counteracts development of CVD. However, the underlying mechanism remained unclear. Here, we investigated the effects of selenium on homocysteine-induced endothelial dysfunction. Methods: An animal model of Hcy-induced...

...Li-Hua Liu; Zheng Guo; Mei Feng; Zhong-Zu Wu; Zhi-Min He; Yan Xiong Background/Aims: Homocysteine-induced endothelial dysfunction favors the development of cardiovascular diseases through accumulation of endogenous nitric oxide (NO) synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA...

...Antony Kam; Kong M. Li; Valentina Razmovski-Naumovski; Srinivas Nammi; Kelvin Chan; George Q. Li Disruption to the vascular homoeostasis is detrimental in vascular diseases. This study examined how the combination of homocysteine, adenosine and tumor necrosis factor-alpha (TNF-α) influenced...

...Jessica A. Sipkens; Nynke E. Hahn; Geerten P. van Nieuw-Amerongen; Coen D.A. Stehouwer; Jan A. Rauwerda; Victor W.M. van Hinsbergh; Hans W.M. Niessen; Paul A.J. Krijnen Aims: Increased levels of homocysteine (Hcy) form an independent risk factor for cardiovascular disease. In a previous study we...