...Lili Zhu; Tingting Ren; Zixin Zhu; Mingliang Cheng; Qiuju Mou; Mao Mu; Yongmei Liu; Yumei Yao; Yiju Cheng; Baofang Zhang; Zhuo Cheng Background/Aims: Hepatic stellate cells (HSCs) are the primary cell type responsible for liver fibrosis. Our study proved that thymosin beta 4 (Tβ4) has anti...

... induced by high fat diet (HFD). Here, we examined the effects of FNDC5 on liver fibrosis and underline mechanisms. Methods: Experiments were carried out on wild-type and FNDC5 -/- mice, primary mouse hepatic stellate cells (HSCs) and human hepatic stellate cell line (LX-2). The mice were fed with HFD...

...Fujun Yu; BiCheng Chen; XuFei Fan; Guojun Li; Peihong Dong; Jianjian Zheng Background/Aims: Recently, microRNAs (miRNAs) have been demonstrated to act as regulators of activation of hepatic stellate cells (HSCs). It is well known that the main profibrogenic inducer transforming growth factor-β1...

...Can-Jie Guo; Xiao Xiao; Li Sheng; Lili Chen; Wei Zhong; Hai Li; Jing Hua; Xiong Ma Background/Aims: To analyze the long noncoding (lncRNA)-mRNA expression network and potential roles in rat hepatic stellate cells (HSCs) during activation. Methods: LncRNA expression was analyzed in quiescent...

...Fujun Yu; Jianhuan Yang; Kate Huang; Xiaodong Pan; BiCheng Chen; Peihong Dong; Jianjian Zheng Background/Aims: In liver fibrosis, the activation of hepatic stellate cells (HSCs) is considered as a pivotal event. It is well known that transforming growth factor-β1 (TGF-β1) is the main stimuli factor...

...Fujun Yu; XuFei Fan; Bicheng Chen; Peihong Dong; Jianjian Zheng Background/Aims: Wnt/β-catenin pathway is involved in liver fibrosis and microRNAs (miRNAs) are considered as key regulators of the activation of hepatic stellate cells (HSCs). A recent study showed the protective role of miR-378a-3p...

...Min-Jin Kim; Sang-A Park; Chun Hwa Kim; So-Yeon Park; Jung-Shin Kim; Dae-Kee Kim; Jeong-Seok Nam; Yhun Yhong Sheen Background/Aims: Hypoxia is an environmental factor that aggravates liver fibrosis. HIF1α activates hepatic stellate cells (HSCs) and increases transforming growth factor-β (TGF-β...

...Yongtao Xiao; Chunying Qu; Wensong Ge; Baocan Wang; Jianxin Wu; Leiming Xu; Yingwei Chen Background & Aims: It has recently been reported that thymosin beta-4 (Tβ4) has anti-fibrogenic effects in human hepatic stellate cells (HSCs) in vitro , but the mechanisms underlying these effects remain...

...-lived mice. Methods: Hepatic stellate cells isolated from naked mole rats were treated with 50 nM rapamycin or 20 mM 3-methyladenine (3-MA) for 12 or 24 h. Expression of the autophagy marker proteins LC3-II and beclin 1 was measured with western blotting and immunohistochemistry. The induction...