... paper addressed the putative hepatoprotective effects of trolline. Methods: Rats received 2 ml/kg CCl 4 (mixed 1: 1 in peanut oil) intragastrically twice a week for 8 weeks to induce hepatic fibrosis. The animals were then treated with trolline for additional 4 weeks. Liver pathology and collagen...

...Ji Xuan; Wei Wen; Yong Wang; Feng Wang; Hua-bing Xu; Mei Shao; Ya Yang; Yao-zhou Tian Background: Biliary cirrhosis (BC) is a chronic cholestatic liver disease, in which hepatic fibrosis is an early symptom. This study aimed to identify the biological function and the therapeutic effect...

... hepatic fibrosis function via protease-activated receptor-2 (PAR2) mechanisms. We hypothesized that AGS affects PAR2 signaling pathway thereby improving hepatic function in rats with hepatic fibrosis induced by carbon tetrachloride (CCl 4 ). We further hypothesized that AGS attenuates impaired hepatic...

..., invasion and metastasis of tumor cells. However, the role of RKIP in chronic liver injury and particularly in liver fibrosis is still unclear. Methods: In the present study, hepatic fibrosis was induced by porcine serum (PS) in rats and primary hepatic stellate cells (HSCs) were isolated from rat livers...

...Hao Chen; Yu Zhou; Ke Quan Chen; Geng An; Su Yun Ji; Qi Kui Chen Background: Hepatic stellate cells (HSCs), the central cells in hepatic fibrosis, are characterized by sustaining activation, a process that consists in increased proliferation and over-expression of fibrotic genes. Transcription...