... lead to heart failure (HF) and constitutes a major cause of pediatric HF with a series of often-fatal consequences. The etiology of VSD with HF is complex, and increasing evidence points toward a genetic basis. Indeed, we identified an L2483R mutation in the ryanodine receptor type 2 (RyR2) in a 2...

...Chunli Wang; Fei Wang; Qing Cao; Zhen Li; Liya Huang; Shuyan Chen Background/Aims: Heart failure is the end result of various kinds of cardiovascular diseases. It has a high rate of morbidity and mortality. This article aims to determine the effect of MeCP2, a key epigenetic regulator, on heart...

... are an independent marker of cardiovascular mortality in cardiac disease. However, whether the development of postinfarction heart failure is associated with changes in CCK expression is unknown. Methods: To investigate CCK expression patterns and the association between CCK expression and heart functional...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Heart failure Pulmonary hypertension Left heart diseases Biomarker, microRNA Cellular Physiology Cell Physiol Biochem 2017;41:2150-2160...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Renal Denervation Carvedilol Heart Failure Fibrosis Vascular Remodeling Cardiac pressure overload leads to maladaptive myocardial...

...Jihong Xing; Jianhua Li Background/Aims: Published data suggest that purinergic P2X receptors of muscle afferent nerves contribute to the enhanced sympathetic nervous activity (SNA) and blood pressure (BP) responses during static exercise in heart failure (HF). In this study, we examined engagement...

...Guang Tong; Ben Zhang; Xuan Zhou; Jinbo Zhao; Zhongchan Sun; Ye Tao; Jianming Pei; Weida Zhang Backgrounds/Aims: The selective κ-opioid agonist U50,488H protects heart from myocardial ischemia-reperfusion (MI/R) injury. We examined whether U50,488H is also beneficial for MI/R induced heart failure...

...Ming Su; Zhiguo Chen; Changxin Wang; Lei Song; Yubao Zou; Lianfeng Zhang; Rutai Hui; Jizheng Wang Background: MicroRNAs play a crucial role in the regulation of pathological cardiac remodeling and heart failure. Previously, we found that overexpression of miR-221 induces heart failure in mice...

...Feifei Zhang; Yi Dang; Yingxiao Li; Qingqing Hao; Rong Li; Xiaoyong Qi Backgroun/Aims: To explore the effect of cardiac contractility modulation (CCM) on myocardial fibrosis in heart failure and to investigate the underlying mechanism. Methods: Rabbits were randomly divided into sham group, HF...

...) and heart failure (HF). Methods: A hypergeometric analysis, in combination with network-based functional analyses, was performed on the available human protein interaction and miRNA-gene association data to highlight versatile miRNAs among the significantly dysregulated miRNAs in MI and HF. In vivo , mice...

...; Marina P. Okoshi Background: Chronic heart failure is characterized by decreased exercise capacity with early exacerbation of fatigue and dyspnea. Intrinsic skeletal muscle abnormalities can play a role in exercise intolerance. Causal or contributing factors responsible for muscle alterations have...

... diseases, such as cancer and the HELLP and the brachydactyly syndromes. However, studies of LncRNA in heart failure have not yet been reported. Here, we investigated cardiac lncRNA expression profiles in the myocardial-specific knockout pdk1 gene (KO) mouse model of heart failure. Methods: Cardiac samples...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Papillary muscle Spironolactone Ventricular function Heart failure Myocardial function Echocardiogram Chronic...

...Jakob Voelkl; Venkanna Pasham; Mohamed Siyabeldin E. Ahmed; Britta Walker; Kalina Szteyn; Dietmar Kuhl; Bernhard Metzler; Ioana Alesutan; Florian Lang Background/Aims: The serum- and glucocorticoid-inducible kinase Sgk1 contributes to cardiac remodeling and development of heart failure, which...

... the SR and mitochondrial apoptotic pathway, contributing to ventricular dysfunction. However, the role of the calcium-sensing receptor (CaR) in cardiac hypertrophy and heart failure has not been studied. This study examined the possible involvement of CaR in the SR and mitochondrial apoptotic pathway...

... the possible contribution of mitochondria to the anti-hypertrophic effects of the direct renin inhibitor aliskiren in post-infarction heart failure complicated with diabetes in rats. Methods: Diabetes was induced in male Sprague-Dawley rats by a single injection of streptozotocin (IP, 65 mg/kg body weight...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Homocysteine PS exposure RhoA ROCK Flippase Heart failure Cellular Physiology...

... Myocardial infarction Apoptosis Chamber dilation Heart failure Cellular Physiology and Biochemistry Original Paper Cell Physiol Biochem 2011;28:33-40 Accepted: May 31, 2011 The Antiapoptotic Effect of Granulocyte Colonystimulating Factor Reduces Infarct Size and Prevents Heart Failure Development...

...Luc Rochette; Etienne Tatou; Véronique Maupoil; Marianne Zeller; Yves Cottin; Sahed Jazayeri; Roger Brenot; Claude Girard; Michel David; Catherine Vergely Heart failure is characterized by a great number of metabolic and histological defects, however, previous studies did not provide strong...

... Paulista, Botucatu, 2Department of Microbiology and Immunology, Institute of Biosciences, UNESP - Univ Estadual Paulista, Botucatu, 3Chemistry and Biochemistry Department, Institute of Biological Sciences, UNESP - Univ Estadual Paulista, Botucatu Key Words Ventricular function Smoking Heart failure...