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Keywords: HMGB1
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Journal Articles

RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis

Open Access
Subject Area:
Further Areas
Xun Li, Zhanwen Lin, Lei Wang, Qin Liu, Zhi Cao, Zhujuan Huang, Mingtian Zhong, Shuxian Peng, Yingheng Zhang, Yong Li, Xiaodong Ma
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2018) 51 (5): 2198–2211.
https://doi.org/10.1159/000495866
Published Online: 07 December 2018
... pancreatitis. We validated 16 DEGs, consisting of 6 upregulated genes and 10 downregulated genes, involved in pancreatic injury. In particular, the upregulation of Pias3 and downregulation of Hmgb1 in KO pancreata coincided with a reduced severity of pancreatitis. In addition, we found Hmgb1 stimulation...
View articletitled, RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis
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Journal Articles

High Mobility Group Box 1 Regulates Uterine Decidualization through Bone Morphogenetic Protein 2 and Plays a Role in Kruppel-Like Factor 5-Induced Stromal Differentiation

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Kai Wang, Zhan-Qing Yang, Hai-Fan Yu, Yu-Si Wang, Bin Guo, Zhan-Peng Yue
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2018) 48 (6): 2399–2408.
https://doi.org/10.1159/000492655
Published Online: 17 August 2018
...Kai Wang; Zhan-Qing Yang; Hai-Fan Yu; Yu-Si Wang; Bin Guo; Zhan-Peng Yue Background/Aims: High mobility group box 1 (Hmgb1) is associated with a variety of physiological processes including embryonic development, cell proliferation and differentiation, but little information is available regarding...
View articletitled, High Mobility Group Box 1 Regulates Uterine Decidualization through Bone Morphogenetic Protein 2 and Plays a Role in Kruppel-Like Factor 5-Induced Stromal Differentiation
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Journal Articles

HMGB1 Expression Level in Circulating Platelets is not Significantly Associated with Outcomes in Symptomatic Coronary Artery Disease

Open Access
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Dominik Rath, Tobias Geisler, Meinrad Gawaz, Sebastian Vogel
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 43 (4): 1627–1633.
https://doi.org/10.1159/000482026
Published Online: 17 October 2017
...Dominik Rath; Tobias Geisler; Meinrad Gawaz; Sebastian Vogel Background/Aims: Platelets express high-mobility group box 1 (HMGB1), a damage-associated molecular pattern molecule (DAMP) that triggers thrombosis and inflammation when present in extracellular space. The role of platelet-derived HMGB1...
View articletitled, HMGB1 Expression Level in Circulating Platelets is not Significantly Associated with Outcomes in Symptomatic Coronary Artery Disease
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Journal Articles

Mir-22-3p Inhibits Arterial Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia by Targeting HMGB1 in Arteriosclerosis Obliterans

Open Access
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Shui-chuan Huang, Mian Wang, Wei-bin Wu, Rui Wang, Jin Cui, Wen Li, Zi-lun Li, Wen Li, Shen-ming Wang
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 42 (6): 2492–2506.
https://doi.org/10.1159/000480212
Published Online: 22 August 2017
... with control cells. MiR-22-3p overexpression had anti-proliferative and anti-migratory effects and dual-luciferase assay showed that high mobility group box-1 (HMGB1) is a direct target of miR-22-3p in HASMCs. Furthermore, miR-22-3p expression was negatively correlated with HMGB1 expression in ASO tissue...
View articletitled, Mir-22-3p Inhibits Arterial Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia by Targeting HMGB1 in Arteriosclerosis Obliterans
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Journal Articles

Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide

Open Access
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Qin Chaochao, Guohua Lou, Ying Yang, Yanning Liu, Ying Hu, Zheng Min, Ping Chen, Jiliang He, Zhi Chen
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 42 (3): 913–928.
https://doi.org/10.1159/000478646
Published Online: 26 June 2017
... box 1 (HMGB1) signalling pathway via MIP-2 inhibition. Methods: Macrophage cells (RAW264.7, U937 and THP-1 cells) were divided into control and treatments groups. Expression levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), HMGB1, chemokine (C-C motif) ligand-2...
View articletitled, Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide
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Journal Articles

MiR-142-3p Overexpression Increases Chemo-Sensitivity of NSCLC by Inhibiting HMGB1-Mediated Autophagy

Open Access
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Further Areas
Yuqing Chen, Xin Zhou, Jianou Qiao, Aihua Bao
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 41 (4): 1370–1382.
https://doi.org/10.1159/000467896
Published Online: 16 March 2017
...Yuqing Chen; Xin Zhou; Jianou Qiao; Aihua Bao Background: Non-small-cell lung cancer (NSCLC) is a deadly cancer with high mortality rate. Drug resistance represents a main obstacle in NSCLC treatment. High mobility group box-1 (HMGB1) protein promotes drug resistance in NSCLC cells by activating...
View articletitled, MiR-142-3p Overexpression Increases Chemo-Sensitivity of NSCLC by Inhibiting HMGB1-Mediated Autophagy
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Journal Articles

Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells

Open Access
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Further Areas
Yuji Kaneko, Colleen Pappas, Teresita Malapira, Fernando Ĺ. Vale, Naoki Tajiri, Cesar V. Borlongan
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 41 (3): 947–959.
https://doi.org/10.1159/000460513
Published Online: 20 February 2017
...Yuji Kaneko; Colleen Pappas; Teresita Malapira; Fernando Ĺ. Vale; Naoki Tajiri; Cesar V. Borlongan Background/Aims: Neuroinflammatory processes have been implicated in the pathophysiology of seizure/epilepsy. High mobility group box 1 (HMGB1), a non-histone DNA binding protein, behaves like...
View articletitled, Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells
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Journal Articles

Dachengqi Decoction Attenuates Inflammatory Response via Inhibiting HMGB1 Mediated NF-κB and P38 MAPK Signaling Pathways in Severe Acute Pancreatitis

Open Access
Subject Area:
Further Areas
Zhuoan Chen, Yafeng Chen, Liyun Pan, Hongchang Li, Jiamin Tu, Cheng Liu, Xiuqin Dai, Xiaofen Zhang, Guifang Sun, Dianxu Feng
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2015) 37 (4): 1379–1389.
https://doi.org/10.1159/000430403
Published Online: 22 October 2015
... to be beneficial in the comprehensive treatment for pancreatitis patients in clinical practice. However, the molecular mechanism of DCQD on SAP remains unclear. High mobility group box 1(HMGB1) that functions as a damage-associated molecular pattern molecule (DAMP) has attracted much interest. Methods...
View articletitled, Dachengqi Decoction Attenuates Inflammatory Response via Inhibiting HMGB1 Mediated NF-κB and P38 MAPK Signaling Pathways in Severe Acute Pancreatitis
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