... migration and invasion assays, RNA immunoprecipitation, and reporter vector construction and luciferase assays. Results: CRNDE was upregulated in hepatocellular carcinoma (HCC). The overexpression of CRNDE promoted HCC cellular proliferation, migration, and invasion in intro and in vivo , and acted...

...Ying Zhang; Jianliang Xu; Shaoquan Zhang; Jun An; Jin Zhang; Jianglong Huang; Yi Jin Background/Aims: Previous studies have demonstrated that long non-coding RNAs (lncRNAs) may play critical roles in cancer biology, including Hepatocellular carcinoma (HCC). The HOXA cluster antisense RNA2 (HOXA-AS2...

...Mashael R. Al-Anazi; Nyla Nazir; Dilek Colak; Mohammed N. Al-Ahdal; Ahmed A. Al-Qahtani Background/Aims: The hepatitis B virus X protein (HBx) is a viral trans-activator that plays a crucial role in pathogenesis of hepatocellular carcinoma (HCC) via an unknown mechanism. The role of HBx...

...Zhikui Liu; Kangsheng Tu; Yufeng Wang; Bowen Yao; Qing Li; Liang Wang; Changwei Dou; Qingguang Liu; Xin Zheng Background/Aims: Hypoxic microenvironment, a common feature of hepatocellular carcinoma (HCC), can induce HIF-1α expression and promote the epithelial-mesenchymal transition (EMT...

...Jinjin Liu; Jun Rao; Xuming Lou; Jian Zhai; Zhenhua Ni; Xiongbiao Wang Background/Aims: The tripartite motif containing (TRIM) family plays crucial roles in tumor development and progression. However, little is known about the function and mechanism of TRIM11 in hepatocellular carcinoma (HCC...

... of Alpha Fetoprotein (AFP), a cluster lncRNAs were revealed as fingerprints for hepatocellular carcinoma (HCC). In this study, we enrolled all the reported circulating lncRNAs in HCC as candidate targets and examined in an independent cohort. Methods: The candidate lncRNAs were determined by qRT-PCR...

...Fang Yang; Lizhi Lv; Kun Zhang; Qiucheng Cai; Jianyong Liu; Yi Jiang Background/Aims: Increasing evidence has indicated that Forkhead box protein C2 (FOXC2) plays an important role in carcinogenesis. However, the expression and the role of FOXC2 in hepatocellular carcinoma (HCC) have not been...

...Zongqiang Hu; Ding Luo; Dongdong Wang; Linjie Ma; Yingpeng Zhao; Li Li Background/Aims: We performed this study to determine the role of IL-17 in the immune microenvironment of hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC). Methods: HepG2 cells were treated with IL-17, STAT3...

...Yuanqin Yin; Fei Li; Songlin Li; Jingjing Cai; Jing Shi; Youhong Jiang Background/Aims: We investigated the correlation between toll-like receptor 4 (TLR4) and β-catenin for disclosing the potential pathogenesis of hepatocellular carcinoma (HCC). Methods: Immunohistochemical toolkit was implemented...

...Hanzhang Zhu; Qiaoyu Liu; Junwei Tang; Yu Xie; Xiaoliang Xu; Yuanguangyan Zhang; Kangpeng Jin; Beicheng Sun Background & Aims: To investigate the expression and prognostic value of α1-ACT (Alpha1-antichymotrypsin) in patients with HCC (hepatocellular carcinoma) and identify the mechanism...

... (YAP-1) and its roles in T cells within hepatocellular carcinoma (HCC). Methods: The expression and activation of YAP-1 were accessed by real-time PCR, immunohistochemistry staining, western blot, and flow cytometry. The potential regulation effect of YAP-1 on Regulatory T cells (Tregs) differentiation...

...Wei Jing; Ping Luo; Man Zhu; Qian Ai; Hongyan Chai; Jiancheng Tu Background: Hepatocellular carcinoma (HCC) is a malignant tumor worldwide. Due to the lack of early prediction marker, numerous patients were diagnosed in their late stage. The family of cavins plays important roles in caveolae...

...Yang Liu; Yi Chai; Jian Zhang; Junwei Tang Backgroud/Aims: Previous studies have shown that miR-501 is involved in the development of hepatocellular carcinoma (HCC) by promoting cell proliferation through CYLD. From the published MirSNP database that enrolls all single nucleotide polymorphisms(SNPs...

...Wenwen Sun; Friederike Katharina Kosyna; Wolfgang Jelkmann; Reinhard Depping Background: Increased red blood cell count (Erythrocytosis) is an important paraneoplastic syndrome of hepatocellular carcinoma (HCC) and is a significant risk factor for lethal lung artery thromboembolism. HCC-associated...

...Feng Gao; Xiaoyu Sun; Likun Wang; Shunxiong Tang; Changqing Yan Background: Hepatitis B viral infection-induced hepatocellular carcinoma (HCC) is a major threat to human health in China. Hepatitis B virus X protein (HBX), an HBV protein, has been reported to be involved in regulating the cellular...

...Huaqiang Zhu; Xu Zhou; Chaoqun Ma; Hong Chang; Hongguang Li; Fangfeng Liu; Jun Lu Background/Aims: miR-448 has been reported to exhibit abnormal expression in hepatocellular carcinoma (HCC), however, the essential role of miR-448 in HCC progression is still unclear. Methods: real-time PCR was used...

... related to p53 down-regulated. Conclusion: miR-34a plays an important role in the anti-tumor effects of querctin in HCC, miR-34a may be a tiemolecule between the p53 and SIRT1 and is composed of a p53/miR-34a/SIRT1 signal feedback loop, which could enhance apoptosis signal and significantly promote cell...

... to regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) progression in a mouse model by inducing Treg cell polarization. Methods: HCC progression, TGF-β and Foxp3 expression levels, serum TGF-β, IL10 and GP73 levels as well as percentage of Treg cells were analyzed in healthy, HCC...

... the mRNAs of hundreds of genes that modulate a variety of biological processes, including cellular differentiation, apoptosis, metabolism, and proliferation. Methods/Results: we analyzed the expression levels of mir-127 in 33 HCC and non-cancerous tissues using qRT-PCR. MiR-127 is downregulated in 69.7...

... HIF-1α expression. Thus, SSd can be used as a potential sensitizer in hepatoma radiotherapy. Hypoxia HCC Radiation Cobalt chloride HIF-1α 2 12 2013 2 1 2014 © 2014 S. Karger AG, Basel 2014 Open Access License / Drug Dosage / Disclaimer Open Access License...