... metabolism of glutathione (GSH), which may increase the risk of the oxidative damage of RBCs after transfusion. The responsible mechanisms remain unknown. Methods: We determined the L-cysteine efflux and influx by evaluating the changes of free -SH concentrations in stored RBCs. The glutamate cysteine ligase...

... had the ability to induce sperm head remodeling during fertilization. Interestingly, excessive mitochondrial activation in Gas6 -depleted MII oocytes caused ROS generation and glutathione (GSH) degradation via mitochondrial activation, such as elevated ΔΨm and ATP production. Indeed, HS-treated NIH3T3...

... smoke in vivo and in vitro , induces cell oxidative stress and affects the antioxidative glutathione system. We evaluated the impact of CSE on airway epithelial cells and the possible cytoprotective effect of the mucolitic drug S-carboximethilcysteine lysine salt (S-CMC-Lys). Methods: Reduced...

... smoke exposure on mitochondrial functions and glutathione-dependent redox metabolism in tissues of BALB/C mice. Liver, kidney, heart and lung tissues were analyzed for oxidative stress, glutathione (GSH) and cytochrome P450 dependent enzyme activities and mitochondrial functions after exposure to smoke...

... contributing to suicidal cell death, e.g. Ca 2+ leakage or glutathione depletion. The present study utilized Western blotting to search for NFĸB and IĸB-α expression in erythrocytes, FACS analysis to determine cytosolic Ca 2+ (Fluo3 fluorescence), phosphatidylserine exposure (annexin V binding), and cell...

... a minor loss of K + which is accompanied by net uptake of Na + following 18 hours cisplatin exposure in ELA. Glutathione and taurine have previously been demonstrated to protect cells from apoptosis. We find, however, that increase or decrease in the cellular content of glutathione and taurine has...

...Shujie Shi; Sylvia Notenboom; Mark E. Dumont; Nazzareno Ballatori In an attempt to identify genes involved in glutathione (GSH) transport, a human mammary gland cDNA library was screened for clones capable of complementing a defect in GSH uptake in yeast cells that lack Hgt1p, the primary yeast GSH...

...Maria Lisa Garavaglia; Elena Bononi; Silvia Dossena; Anna Mondini; Claudia Bazzini; Luigi Lanata; Rossella Balsamo; Michela Bagnasco; Massimo Conese; Guido Bottà; Markus Paulmichl; Giuliano Meyer The mucoactive drug S-carbocysteine lysine salt monohydrate (S-CMC-Lys) stimulates glutathione (GSH...

... + currents measured in central neurones. K+ channels Cloned Site-directed mutagenesis Structure-function relation Inactivation Granule cells Glutathione Expression pattern Patch clamp Cell Physiol Biochem 1993;3:250-269 J. Peter Ruppersberg Manfred Ermler Martin Knopf Wilfried Kues Peter Jonas...